| Identification | Back Directory | [Name]
Propargyl-PEG7-acid | [CAS]
2093154-00-6 | [Synonyms]
CAS_2093154-00-6
Propargyl-PEG7-acid
Propargyl-PEG6-CH2CH2COOH
4,7,10,13,16,19,22-Heptaoxapentacos-24-ynoic acid | [Molecular Formula]
C18H32O9 | [MDL Number]
MFCD22683301 | [MOL File]
2093154-00-6.mol | [Molecular Weight]
392.44 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG7-acid is a reagent with a propargyl group with a carboxylic acid. The carboxylic acid reacts with primary amines under the activation of EDC or HATU. The propargyl group can participate in azide-alkyne Click Chemistry reaction to form triazole linkage, copper is required as a catalyst. The PEG spacer increases the hydrophilicity of the molecule. | [Uses]
Propargyl-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG7-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG7-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Cleavable Linker; PEGs | [References]
[1] Anandan Palani, et al. Insulin-incretin conjugates. WO2017160669A1. |
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