| Identification | More | [Name]
2,4-Dinitrofluorobenzene | [CAS]
70-34-8 | [Synonyms]
1,3-DINITRO-4-FLUOROBENZENE
1-FLUORO-2,4-DINITROBENZENE
2,4-DINITRO-1-FLUOROBENZENE
2,4-DINITROFLUOROBENZENE
DNF
DNFB
DNF OR DNFB
DNPF
FDNB
SANGER REAGENT
SANGER'S REAGENT
1,2,4-Fluorodinitrobenzene
1-fluoro-2,4-dinitro-benzen
2,4-dinitro-1-fluoro-benzen
2,4-Dinitrobenzenefluoride
2,4-Dinitrophenyl fluoride
2,4-Dnfb
Benzene, 2,4-dinitro-1-fluoro-
Dinitrofluorobenzene
Fluoro-2,4-Dinitrobenzene | [EINECS(EC#)]
200-734-3 | [Molecular Formula]
C6H3FN2O4 | [MDL Number]
MFCD00007056 | [Molecular Weight]
186.1 | [MOL File]
70-34-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow solid | [Melting point ]
25-27 °C(lit.)
| [Boiling point ]
178 °C25 mm Hg(lit.)
| [density ]
1.482 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.569(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
chloroform: 0.1 g/mL, clear
| [form ]
Liquid or Low Melting Crystals | [color ]
Yellow to brownish | [Specific Gravity]
1.482 | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases. | [Water Solubility ]
400 mg/L (25 ºC) | [Merck ]
14,4172 | [BRN ]
398632 | [Contact allergens]
DNFB is a strong skin irritant and a universal contact allergen. It is used as an intermediate in the synthesis of pesticides and pharmaceuticals such as flurbiprofen, a chemical reagent, and as a topical sensitizer for the treatment of alopecia areata | [CAS DataBase Reference]
70-34-8(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzene, 1-fluoro-2,4-dinitro-(70-34-8) | [EPA Substance Registry System]
70-34-8(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow solid | [Uses]
A substituted benzene use in polypeptide sequencing (also referred to as Sanger’s reagent). Used in the derivitization of primary amines. Shown to inhibit the reductase activity of mitochondrial b-c1 complex isolated from beef heart mitochondria. | [Definition]
ChEBI: The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2and 4-positions. | [General Description]
Clear yellow crystals or yellow crystalline solid. | [Reactivity Profile]
Reacts with oxidizing agents . When air was admitted after vacuum evaporation of an ether peroxide solution, a violent explosion occurred. A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups. | [Air & Water Reactions]
Slightly soluble in water. | [Fire Hazard]
This chemical is probably combustible. | [Biochem/physiol Actions]
1-Fluoro-2,4-dinitrobenzene is a contact-sensitizing hapten, commonly used in experimental studies on contact hypersensitivity, inducing itch model, and atopic dermatitis. Mast cell activation is a key step in the DNFB induced sensitivity. DNFB covalently binds to the N-terminal amino acid of the protein and aids in Sanger sequencing. | [Purification Methods]
Crystallise the reagent from Et2O or EtOH. Distil it in a vacuum through a Todd Column (p 11). If it is to be purified by distillation in vacuo, the distillation unit must be allowed to cool before air is allowed into the apparatus; otherwise the residue carbonises spontaneously and an EXPLOSION may occur. The material is a skin irritant and may cause serious dermatitis. [Beilstein 5 IV 742.] |
| Safety Data | Back Directory | [Hazard Codes ]
C,T | [Risk Statements ]
R22:Harmful if swallowed.
R33:Danger of cumulative effects.
R34:Causes burns.
R42/43:May cause sensitization by inhalation and skin contact .
R40:Limited evidence of a carcinogenic effect.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R43:May cause sensitization by skin contact.
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S7/9:Keep container tightly closed and in a well-ventilated place . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [RTECS ]
CZ7800000
| [Hazard Note ]
Toxic | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29049085 | [Safety Profile]
Poison by ingestion,skin contact, and subcutaneous routes. A powerful irritant and vesicant. Mutation data
reported. Solutions in ether may explode
when evaporated* When heated to
decomposition it emits highly toxic fumes of
NOx and F-. See also NITRO
E COMPOUNDS of AROMATIC
HYDROCARBONS and FLUORIDES. | [Hazardous Substances Data]
70-34-8(Hazardous Substances Data) |
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