(4-Fluoro-phenyl)-oxo-acetaldehyde
- CAS No.
- 403-32-7
- Chemical Name:
- (4-Fluoro-phenyl)-oxo-acetaldehyde
- Synonyms
- NSC 402742;4-FLUOROPHENYLGLYOXAL;(p-Fluorophenyl)glyoxal;(4-Fluoro-phenyl)-oxo-acetaldehyde;4-Fluoro-α-oxo-benzeneacetaldehyde;Benzeneacetaldehyde, 4-fluoro-α-oxo-;4-fluoro-alpha-oxobenzeneacetaldehyde;4-fluoro-alpha-oxo-benzeneacetaldehyd;Benzeneacetaldehyde, 4-fluoro-.alpha.-oxo-;4-Fluoro-α-oxo-benzeneacetaldehyde, CAS 403-32-7
- CBNumber:
- CB8388962
- Molecular Formula:
- C8H5FO2
- Molecular Weight:
- 152.12
- MDL Number:
- MFCD01733156
- MOL File:
- 403-32-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,681mg/kg (681mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION,Journal of the Indian Chemical Society. Vol. 60, Pg. 369, 1983. | |||||||||
| NFPA 704 |
|
(4-Fluoro-phenyl)-oxo-acetaldehyde price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA003LDF | (4-Fluorophenyl)glyoxal 98% | 403-32-7 | 1g | $18 | 2026-05-28 | Buy |
| aablocks | AA003LDF | (4-Fluorophenyl)glyoxal 98% | 403-32-7 | 5g | $23 | 2026-05-28 | Buy |
| aablocks | AA003LDF | (4-Fluorophenyl)glyoxal 98% | 403-32-7 | 25g | $84 | 2026-05-28 | Buy |
| aablocks | AA003LDF | (4-Fluorophenyl)glyoxal 98% | 403-32-7 | 100g | $274 | 2026-05-28 | Buy |
| aablocks | AA003LDF | (4-Fluorophenyl)glyoxal 98% | 403-32-7 | 500g | $1074 | 2026-05-28 | Buy |
(4-Fluoro-phenyl)-oxo-acetaldehyde Chemical Properties, Uses, Production
Chemical Properties
White Solid
Uses
4-Fluoro-α-oxo-benzeneacetaldehyde (cas# 403-32-7) is a compound useful in organic synthesis.
Synthesis
403-42-9
403-32-7
The general procedure for the synthesis of 4-fluorobenzoylformaldehyde from 4-fluoroacetophenone was as follows: selenium dioxide (6.70 g, 61.0 mmol) was added to a mixed solution of dioxane (100 mL) and water (3 mL) containing 4-fluoroacetophenone (8.43 g, 61.0 mmol). The resulting mixture was heated at 55 °C until selenium dioxide was completely dissolved. Subsequently, the reaction mixture was refluxed for 5 to 6 hours. After monitoring the completion of the reaction by thin layer chromatography (TLC), the mixture was filtered and the filtrate was concentrated under vacuum to obtain a viscous oily substance. Water (50 mL) was added to the oily substance and the resulting mixture was stirred for 12 hours. Afterwards, the solid formed was collected on a filter, washed with water (25 mL) and dried under vacuum to finally obtain 4-fluorophenylglyoxal (6.60 g, 85% yield).1H NMR (400 MHz, CDCl3) δ: 7.18 (m, 2H), 8.11 (d, 2H), no signal for aldehyde CHO was observed.
References
[1] Patent: WO2011/95625, 2011, A1. Location in patent: Page/Page column 94
[2] Tetrahedron Letters, 2017, vol. 58, # 7, p. 658 - 662
[3] Patent: WO2007/39821, 2007, A2. Location in patent: Page/Page column 16
[4] Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 1651 - 1653
[5] Angewandte Chemie - International Edition, 2016, vol. 55, # 36, p. 10890 - 10894
(4-Fluoro-phenyl)-oxo-acetaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
(4-Fluoro-phenyl)-oxo-acetaldehyde Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Candia Thamtech Company Limited | 0371-86615086 18203638366 0371-86159066 13526786601 | China | 2011 | 60 | |
| Chengdu DingDang Pharmaceutical Co., Ltd. | 028-86040038 | market@dingdangchem.com | China | 1853 | 55 |
| parabiochem | 025-83453382-8005 | sale@parabiochem.com | China | 9577 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
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