tert-Butyl (6-Chloropyridin-2-yl)-carbamate
- CAS No.
- 159603-71-1
- Chemical Name:
- tert-Butyl (6-Chloropyridin-2-yl)-carbamate
- Synonyms
- 2-BOC-Amino-6-chloropyridine;tert-Butyl (6-chloropyridin-2-yl);2-Amino-6-chloropyridine, 2-Boc protected;t-butyl N-(6-chloro-2-pyridinyl)carbamate;ert-Butyl (6-Chloropyridin-2-yl)-carbamate;tert-butyl N-(6-chloro-2-pyridyl)carbamate;2-tert-Butoxycarbonylamino-6-chloropyridine;tert-Butyl (6-Chloropyridin-2-yl)-carbamate;tert-Butyl N-(6-chloropyridin-2-yl)carbamate;2-Amino-6-chloropyridine, 2-BOC protected 97%
- CBNumber:
- CB01501704
- Molecular Formula:
- C10H13ClN2O2
- Molecular Weight:
- 228.68
- MDL Number:
- MFCD09030821
- MOL File:
- 159603-71-1.mol
- MSDS File:
- SDS
| Melting point | 87.5-89℃ |
|---|---|
| Boiling point | 282.2±25.0 °C(Predicted) |
| Density | 1.245±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 11.89±0.70(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C10H13ClN2O2/c1-10(2,3)15-9(14)13-8-6-4-5-7(11)12-8/h4-6H,1-3H3,(H,12,13,14) |
| InChIKey | UEYNRRQJJHZENW-UHFFFAOYSA-N |
| SMILES | C(OC(C)(C)C)(=O)NC1=NC(Cl)=CC=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
tert-Butyl (6-Chloropyridin-2-yl)-carbamate price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR902051 | 2-Amino-6-chloropyridine, 2-BOC protected 97% | 159603-71-1 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR902051 | 2-Amino-6-chloropyridine, 2-BOC protected 97% | 159603-71-1 | 100g | $588 | 2026-06-04 | Buy |
| Synthonix | B52891 | tert-Butyl (6-chloropyridin-2-yl)carbamate 97% | 159603-71-1 | 1g | $35 | 2026-05-06 | Buy |
| Synthonix | B52891 | tert-Butyl (6-chloropyridin-2-yl)carbamate 97% | 159603-71-1 | 5g | $41 | 2026-05-06 | Buy |
| Synthonix | B52891 | tert-Butyl (6-chloropyridin-2-yl)carbamate 97% | 159603-71-1 | 10g | $80 | 2026-05-06 | Buy |
tert-Butyl (6-Chloropyridin-2-yl)-carbamate Chemical Properties,Uses,Production
Uses
tert-Butyl (6-Chloropyridin-2-yl)carbamate is used in preparation of Tetrahydro-1,8-naphthyridine compounds as ανβ6 integrin inhibitors useful for treatment.
Synthesis
45644-21-1
24424-99-5
159603-71-1
A solution was prepared by dissolving 32.7 g (0.15 mol) di-tert-butyl dicarbonate (Boc anhydride) in 100 mL of tetrahydrofuran (THF) under nitrogen protection. This solution was slowly added dropwise to a reaction system containing 17.4 g (0.14 mol) of 2-amino-6-chloropyridine and 300 mL (0.30 mol) of 1 M sodium hexamethyldisilazide in THF (in 200 mL of THF). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the solvent was removed by rotary evaporation. The residue was partitioned between ethyl acetate (EtOAc) and 1 N aqueous hydrochloric acid solution, and the organic phase was separated after thorough stirring. The aqueous phase was extracted once more with EtOAc. All organic phases were combined and washed with 300 mL of saturated sodium bicarbonate solution, subsequently dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by recrystallization from ethanol (EtOH) and the solid obtained was collected by filtration and dried. The final product was 2-Boc-amino-6-chloropyridine in a yield of 29.2 g in 95% yield. The product was characterized by ESI-MS: m/z = 228 (M+) and HPLC retention time (Rt) was 1.70 min (Method C).
References
[1] Patent: US2011/21500, 2011, A1. Location in patent: Page/Page column 45
[2] Patent: US2011/172218, 2011, A1. Location in patent: Page/Page column 29
[3] Patent: US2012/149698, 2012, A1. Location in patent: Page/Page column 26
[4] Journal of Organic Chemistry, 2005, vol. 70, # 5, p. 1771 - 1779
[5] Patent: US2009/258877, 2009, A1. Location in patent: Page/Page column 16-17
tert-Butyl (6-Chloropyridin-2-yl)-carbamate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Taifu Pharmaceutical Technology Co., LTD | 13524951390 18930958102 | 1457818861@qq.com | China | 711 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7882 | 64 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Beijin Yangguang Furui Chemical co.,Ltd. | 010-57495520 13521095525 | zhw512@foxmail.com | China | 487 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Lastest Price from tert-Butyl (6-Chloropyridin-2-yl)-carbamate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | tert-Butyl (6-Chloropyridin-2-yl)-carbamate
159603-71-1
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited |
-
- tert-Butyl (6-Chloropyridin-2-yl)-carbamate
159603-71-1
- $1.10
- 99.00%
- Dideu Industries Group Limited
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