2-methyl-2-(4-nitrophenyl)propanenitrile
- CAS No.
- 71825-51-9
- Chemical Name:
- 2-methyl-2-(4-nitrophenyl)propanenitrile
- Synonyms
- 2-methyl-2-(4-nitrophenyl)propanenitrile;2-Methyl-2-(4-nitro-phenyl)-propionitrile;Benzeneacetonitrile, α,α-dimethyl-4-nitro-;BENZENEACETONITRILE, A,A-DIMETHYL-4-NITRO-;alpha,alpha-Dimethyl-4-nitrobenzeneacetonitrile
- CBNumber:
- CB01564480
- Molecular Formula:
- C10H10N2O2
- Molecular Weight:
- 190.2
- MDL Number:
- MFCD00844930
- MOL File:
- 71825-51-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2926907090 |
2-methyl-2-(4-nitrophenyl)propanenitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR909564 | 2-Methyl-2-(4-nitrophenyl)propanenitrile 95% | 71825-51-9 | 1g | $89 | 2026-06-04 | Buy |
| Apolloscientific | OR909564 | 2-Methyl-2-(4-nitrophenyl)propanenitrile 95% | 71825-51-9 | 5g | $209 | 2026-06-04 | Buy |
| Activate Scientific | AS59250 | 2-Methyl-2-(4-nitrophenyl)propanenitrile 97% | 71825-51-9 | 1g | $25 | 2026-06-04 | Buy |
| Activate Scientific | AS59250 | 2-Methyl-2-(4-nitrophenyl)propanenitrile 97% | 71825-51-9 | 5g | $106 | 2026-06-04 | Buy |
| Activate Scientific | AS59250 | 2-Methyl-2-(4-nitrophenyl)propanenitrile 97% | 71825-51-9 | 25g | $405 | 2026-06-04 | Buy |
2-methyl-2-(4-nitrophenyl)propanenitrile Chemical Properties, Uses, Production
Uses
2-Methyl-2-(4-nitrophenyl)propionitrile is a nitrile derivative that can be used as a pharmaceutical intermediate.
Synthesis
555-21-5
74-88-4
71825-51-9
1. Sodium tert-butoxide (662 mg, 6.47 mmol) was suspended in DMF (20 mL) at 0 °C. 2. 4-nitrophenylacetonitrile (1000 mg, 6.18 mmol) was added to the above suspension and the reaction was stirred for 10 min. 3. Iodomethane (400 μL, 6.47 mmol) was added dropwise over 15 min, keeping the reaction temperature at 0-10 °C. 4. 4. The reaction mixture was stirred at 0-10 °C for 15 min, then brought to room temperature and continued stirring for 15 min. 5. Sodium tert-butoxide (662 mg, 6.47 mmol) was added again and the reaction was stirred for 15 minutes. 6. Iodomethane (400 μL, 6.47 mmol) was added dropwise over 15 minutes and the reaction mixture was stirred overnight. 7. Sodium tert-butoxide (192 mg, 1.94 mmol) was added and the reaction was stirred at 0 °C for 10 min. 8. iodomethane (186 μL, 2.98 mmol) was added and the reaction was stirred for 1 hour. 9. The reaction mixture was partitioned with 1N HCl (50 mL) and ethyl acetate (75 mL). 10. The organic layer was washed sequentially with 1N HCl and saturated saline, dried over anhydrous sodium sulfate and concentrated. 11. 2-Methyl-2-(4-nitrophenyl)propionitrile was obtained as a green waxy solid (1.25 g, 99% yield). 12. The product was analyzed by 1H NMR. 12. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.24 (d, J = 8.9 Hz, 2H), 7.66 (d, J = 8.9 Hz, 2H), 1.77 (s, 6H).
References
[1] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 0720
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992, # 17, p. 2203 - 2214
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4834 - 4848
[4] Patent: WO2018/208132, 2018, A1. Location in patent: Paragraph 321-325
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7585 - 7596
2-methyl-2-(4-nitrophenyl)propanenitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
| Nanjing JinruiJiuAn Biotechnology Co., Ltd. | 025-58196018 800028039 | sales@fartop.net | China | 2227 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| EnliPharma Technology Co., Ltd | 0551-66399836 18955197623 | sales@enlipharma.com | China | 1875 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 2-methyl-2-(4-nitrophenyl)propanenitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-01-15 | 2-methyl-2-(4-nitrophenyl)propanenitrile
71825-51-9
|
1KG | 97.3% | 100 tons | Honest Joy Holdings Limited | ||
 |
2020-01-03 | 2-methyl-2-(4-nitrophenyl)propanenitrile
71825-51-9
|
$1.00 | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
-
- 2-methyl-2-(4-nitrophenyl)propanenitrile
71825-51-9
- $0.00
- 97.3%
- Honest Joy Holdings Limited
-
- 2-methyl-2-(4-nitrophenyl)propanenitrile
71825-51-9
- $1.00
- 95-99%
- Career Henan Chemical Co
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