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BOC-L-4-Nitrophe

BOC-L-4-Nitrophe structure

CAS No.: 33305-77-0

Chemical Name:: BOC-L-4-Nitrophe

Synonyms: Phe(4-NO2);D-Phe.otBu.HCl;BOC-L-4-NITROPHE;BOC-L-PHE(4-NO2);Boc-4-NO2-Phe-OH;BOC-PHE(4''-NO2);BOC-(P-NO2)PHE-OH;BOC-PNO2-L-PHE-OH;BOC-PHE(4-NO2)-OH;BOC-PHE(P-NO2)-OH

CBNumber:: CB0178783

Molecular Formula:: C14H18N2O6

Molecular Weight:: 310.3

MDL Number:: MFCD00038128

MOL File:: 33305-77-0.mol

MSDS File:: SDS

Last updated:2026-01-13 11:12:42

Product description	Number	Pack Size	Price
Boc-Phe(4-NO2)-OH ≥99.0% (T)	15348	1g	$42.9
Boc-Phe(4-NO2)-OH ≥99.0% (T)	15348	5g	$109
N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine >98.0%(T)	B2232	1g	$22
N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine >98.0%(T)	B2232	5g	$29
N-Boc-p-nitro-L-phenylalanine	B658040	5g	$95
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BOC-L-4-Nitrophe Properties

Melting point	107°C
alpha	8 º (c=1,MeOH)
Boiling point	509.3±45.0 °C(Predicted)
Density	1.290±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethanol (Slightly)
pka	3.70±0.10(Predicted)
form	Solid
color	Pale Beige
optical activity	[α]20/D +8±1°, c = 1% in methanol
BRN	2820671
Major Application	peptide synthesis
InChI	InChI=1S/C14H18N2O6/c1-14(2,3)22-13(19)15-11(12(17)18)8-9-4-6-10(7-5-9)16(20)21/h4-7,11H,8H2,1-3H3,(H,15,19)(H,17,18)/t11-/m0/s1
InChIKey	XBQADBXCNQPHHY-NSHDSACASA-N
SMILES	C(O)(=O)[C@H](CC1=CC=C([N+]([O-])=O)C=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference	33305-77-0
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Warning

Hazard statements

H314

Precautionary statements

P264b-P271-P280-P301+P330+P331-P304+P340-P305+P351+P338-P310-P363-P403+P233-P501c

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Safety Statements

24/25

WGK Germany

HazardClass

IRRITANT

HS Code

29242990

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

BOC-L-4-Nitrophe price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	15348	Boc-Phe(4-NO2)-OH ≥99.0% (T)	33305-77-0	1g	$42.9	2023-06-20	Buy
Sigma-Aldrich	15348	Boc-Phe(4-NO2)-OH ≥99.0% (T)	33305-77-0	5g	$109	2023-06-20	Buy
TCI Chemical	B2232	N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine >98.0%(T)	33305-77-0	1g	$22	2026-03-19	Buy
TCI Chemical	B2232	N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine >98.0%(T)	33305-77-0	5g	$29	2026-03-19	Buy
TRC	B658040	N-Boc-p-nitro-L-phenylalanine	33305-77-0	5g	$95	2021-12-16	Buy

Product number	Packaging	Price	Buy
15348	1g	$42.9	Buy
15348	5g	$109	Buy
B2232	1g	$22	Buy
B2232	5g	$29	Buy
B658040	5g	$95	Buy

BOC-L-4-Nitrophe Chemical Properties,Uses,Production

Chemical Properties

Light yellow powder

Uses

N-Boc-p-nitro-L-phenylalanine is the N-Boc protected form of p-Nitro-L-phenylalanine (N502725, Hydrate) and is a useful synthetic intermediate in the synthesis of Hydroxymelphalan (H939850); an analog of Melphalan (M216900) which is an antineoplastic.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

949-99-5

33305-77-0

To a stirred solution of 4.0 g of (S)-2-amino-3-(4-nitrophenyl)propanoic acid (0.019 mol) in 30 cm3 tert-butanol and 0.8 g of NaOH (0.0209 mol, dissolved in 5 cm3 of water) was added slowly and dropwise at 0 °C 5 cm3 of di-tert-butyl dicarbonate (0.0228 mol, dissolved in 5 cm3 of tert-butanol). The reaction mixture was stirred for 10 h at room temperature. After completion of the reaction (confirmed by thin layer chromatography), the solvent was removed by evaporation and the residue was poured into water and extracted with ethyl acetate (2 x 50 cm3). The organic phases were combined, washed sequentially with 50 cm3 10% citric acid solution and 50 cm3 saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give (S)-2-((tert-butoxycarbonyl)amino)-3-(4-nitrophenyl)propionic acid as a white solid. Yield: 5.0 g (86% yield); Melting point: 105-106°C (literature value 105-107°C).

References

[1] Journal of Organic Chemistry, 1996, vol. 61, # 5, p. 1872 - 1874
[2] Journal of Organic Chemistry, 1999, vol. 64, # 10, p. 3467 - 3475
[3] Patent: US2002/35137, 2002, A1
[4] Monatshefte fur Chemie, 2016, vol. 147, # 11, p. 2001 - 2008
[5] Journal of Medicinal Chemistry, 1989, vol. 32, # 3, p. 638 - 643

BOC-L-4-Nitrophe synthesis

Synthesis of BOC-L-4-Nitrophe from Di-tert-butyl dicarbonate and 4-Nitro-3-phenyl-L-alanine

BOC-L-4-Nitrophe Preparation Products And Raw materials

Raw materials

Carbonic acid, (cyanophenylmethyl)azanyl 1,1-dimethylethyl ester (E)-N-((tert-Butoxycarbonyl)oxy)benziMidoyl cyanide N-Boc-4-nitro-L-phenylalanine Methyl Ester 4-Nitro-3-phenyl-L-alanine Bromoethane

tert-Butanol Water Di-tert-butyl dicarbonate tert-butyl azidoformate L-Phenylalanine

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Preparation Products

BOC-L-2-NITROPHENYLALANINE

BOC-L-4-Nitrophe Suppliers

Global( 311)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	+8618382028708	ni@enlaibio.com	China	1098	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	989	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29822	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Sichuan Jiaying Lai Technology Co.,LTD	18716376478	ycling@enlaibio.com	CHINA	302	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58

Supplier	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
AB PharmaTech,LLC	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Sichuan Jiaying Lai Technology Co.,LTD	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from BOC-L-4-Nitrophe manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	Boc-4-NO2-Phe-OH 33305-77-0	US $0.00-0.00 / kg	1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2021-07-13	BOC-L-4-Nitrophe 33305-77-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-02	N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine 33305-77-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Boc-4-NO2-Phe-OH
33305-77-0
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

BOC-L-4-Nitrophe
33305-77-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine
33305-77-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

BOC-L-4-Nitrophe Spectrum

BOC-L-4-Nitrophe(33305-77-0)¹HNMR

33305-77-0(BOC-L-4-Nitrophe )Related Search:

EC 2.6.1.2 4-Nitro-3-phenyl-L-alanine DL-Phenylalanine 4-Nitrobenzoic acid D-Phenylalanine

N-(tert-Butoxycarbonyl)-L-phenylalanine 3-(4-Nitrophenyl)-beta-alanine Boc-Aib-OH D-Alanine N-Carbobenzyloxyglycine

Phenprobamate BOC-4-NITRO-D-PHENYLALANINE,BOC-P-NITRO-D-PHENYLALANINE,N-ALPHA-T-BOC-4-NITRO-D-PHENYLALANINE,BOC-D-4-NITROPHE BOC-PHE(3-I)-OH L-Phenylalanine tert-Butanol

BOC-GLY-LEU-OH BOC-4-Methyl-D-phenylalanine Boc-4-Amino-L-phenylalanine

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BOC-PNO2-L-PHE-OH BOC-(P-NO2)PHE-OH BOC-P-NITRO-PHENYLALANINE BOC-P-NITRO-PHE-OH BOC-PHE(P-NO2)-OH BOC-PHE(4-NO2)-OH BOC-L-4-NITROPHE BOC-L-4-NITROPHENYLALANINE BOC-L-PHE(4-NO2) BOC-L-PHE(4-NO2)-OH BOC-4-NITRO PHENYLALANINE BOC-4-NITRO-PHE-OH BOC-4-NITRO-L-PHENYLALANINE N-(tert-Butyloxycarbonyl)-4-nitro-L-phenylalanine Boc-L-4-NO2-Phe-OH Boc-4-Nitro-L-Phenylalanine N-Boc-4-nitro-L-phenylalanine Boc-Phe(4-NO2)-OH (S)-2-t-butyloxycarbonylaMino-3-(4-nitrophenyl)propionic acid H-Phe(4'-NO2)-OBut·HCl Boc-D-4-Nitro-Phe-OH Boc-4-NO2-Phe-OH (Tert-Butoxy)Carbonyl Phe(4-NO2)-OH Phe(4-NO2) D-Phe.otBu.HCl L-Phenylalanine,N-[(1,1-diMethylethoxy)carbonyl]-4-nitro- (S)-Boc-2-amino-3-(4-nitrophenyl)propionic acid Boc-4-nitro-L-phenylalanine≥ 99% (HPLC) Boc-p-nitro-L-Phe-OH (S)-2-(TERT-BUTOXYCARBONYLAMINO)-3-(4-NITROPHENYL)PROPANOIC ACID RARECHEM BK PT 0074 N-TERT-BUTOXYCARBONYL-4-NITRO-L-PHENYLALANINE N-TBOC-P-NITRO-L-PHENYLALANINE N-ALPHA-T-BUTOXYCARBONYL-(4-NITROPHENYL)-L-ALANINE N-ALPHA-T-BOC-4-NITRO-L-PHENYLALANINE N-ALPHA-TERT-BUTYLOXYCARBONYL-4-NITRO-L-PHENYLALANINE N-ALPHA-T-BUTOXYCARBONYL-P-NITRO-L-PHENYLALANINE N-BOC-4-NITRO-L-PHENYLALANINE Boc-Phe(4-NO₂)-OH N-(tert-butoxycarbonyl)-4-nitro-3-phenyl-L-alanine N-T-BOC-P-NITRO-L-PHENYLALANINE*FREE ACI D 4-Nitro-L-phenylalanine, N-BOC protected N-ALPHA-T-BUTYLOXYCARBONYL-4-NITRO-L-PHENYLALANINE Boc-L-4-NO2-Phe-OH NALPHA-tert-Butoxycarbonyl-3-(4-nitrophenyl)-L-alanine tert-Butoxycarbonyl-L-4-nitrophenylalanine BOC-PHE(4''-NO2) N-TERT-BOC-P-NITRO-L-PHENYLALANINE N-Boc-p-nitro-L-phenylalanine N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine> BOC-L-4-Nitrophe USP/EP/BP Boc-4-nitro-l-phenylalanine, 98%+ BOC-4-Nitro-L-Phenylalanine extrapure, 98% N-Boc-4-nitro-L-phenylalanine, 95%, BOC-4-NITRO-L-PHENYLALANINE 98% (S)-2-(N-BOC-Amino)-3-(4-nitrophenyl)-propanoic acid 33305-77-0 Peptide Synthesis Phenylalanine Derivatives Specialty Synthesis