2-Bromo-3-fluorophenol
- CAS No.
- 443-81-2
- Chemical Name:
- 2-Bromo-3-fluorophenol
- Synonyms
- Bromo-3-fluorophenol;3-Fluoro-2-bromophenol;2-BROMO-3-FLUOROPHENOL;Phenol, 2-bromo-3-fluoro-;2-Bromo-3-fluorophenol ISO 9001：2015 REACH
- CBNumber:
- CB0378327
- Molecular Formula:
- C6H4BrFO
- Molecular Weight:
- 191
- MDL Number:
- MFCD04037220
- MOL File:
- 443-81-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 123 °C(Press: 50 Torr) |
|---|---|
| Density | 1.764±0.06 g/cm3(Predicted) |
| refractive index | 1.56 |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 7.43±0.10(Predicted) |
| form | clear liquid |
| color | Colorless to Light yellow to Light orange |
| CAS DataBase Reference | 443-81-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P310 | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38-22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | UN1760 | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 2908190090 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Bromo-3-fluorophenol price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B5224 | 2-Bromo-3-fluorophenol >98.0%(GC) | 443-81-2 | 1g | $37 | 2026-04-30 | Buy |
| TCI Chemical | B5224 | 2-Bromo-3-fluorophenol >98.0%(GC) | 443-81-2 | 5g | $131 | 2026-04-30 | Buy |
| Biosynth | FB33796 | 2-Bromo-3-fluorophenol | 443-81-2 | 2g | $150 | 2026-06-04 | Buy |
| Biosynth | FB33796 | 2-Bromo-3-fluorophenol | 443-81-2 | 5g | $181.45 | 2026-06-04 | Buy |
| Biosynth | FB33796 | 2-Bromo-3-fluorophenol | 443-81-2 | 10g | $272.1 | 2026-06-04 | Buy |
2-Bromo-3-fluorophenol Chemical Properties, Uses, Production
Description
2-Bromo-3-fluorophenol is a chemical intermediate commonly used in organic synthesis and laboratory research. It can be used to prepare monofluorophenol.
Chemical Properties
light yellow liquid
Uses
2-Bromo-3-fluorophenol has been used as a reactant in the preparation of diaryl ethers.
Synthesis
324769-11-1
443-81-2
1. 120 mL of isopropanol, 200 mL of 6M hydrochloric acid and 81 g (345 mmol) of 1-(methoxymethoxy)-2-bromo-3-fluorophenol were mixed and stirred for 2.5 hours at room temperature. 2. Upon completion of the reaction, the reaction mixture was partitioned. 400 ml of methyl tert-butyl ether and 120 ml of 5N sodium hydroxide were added. 3. The organic phase was separated, washed with saturated aqueous sodium chloride solution and then dried over anhydrous sodium sulfate. 4. The dried organic phase is concentrated under pressure to give an oily residue. 5. purify the residue by silica gel column chromatography and collect the fraction containing 2-bromo-3-fluorophenol. 6. Concentrate the combined fractions under pressure to give 55.1 g (84% yield) of the target compound 2-bromo-3-fluorophenol as a colorless oil.
References
[1] Patent: EP1204660, 2004, B1. Location in patent: Page 19
2-Bromo-3-fluorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 2-Bromo-3-fluorophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-22 | 2-Bromo-3-fluorophenol
443-81-2
|
1KG | 97.5% | 100 tons | Honest Joy Holdings Limited | ||
 |
2021-08-12 | 2-Bromo-3-fluorophenol
443-81-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-13 | 2-Bromo-3-fluorophenol
443-81-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-Bromo-3-fluorophenol
443-81-2
- $0.00
- 97.5%
- Honest Joy Holdings Limited
-
- 2-Bromo-3-fluorophenol
443-81-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-Bromo-3-fluorophenol
443-81-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
