Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>4-Amino-3,5-dichloroacetophenone

4-Amino-3,5-dichloroacetophenone

4-Amino-3,5-dichloroacetophenone Structure
4-Amino-3,5-dichloroacetophenone structure
CAS No.
37148-48-4
Chemical Name:
4-Amino-3,5-dichloroacetophenone
Synonyms
1-(4-amino-3,5-dichlorophenyl)ethan-1-one;3,5-DICHLORO-4-AMINOACETOPHENONE;1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone;5-dichlorophenyl)-;TIMTEC-BB SBB003511;3,5-dichloro-4-amino;Clenbuterol EP Impurity C;4-ACETYL-2,6-DICHLOROANILINE;3, 5-dichloro-4-aminophenone;4-Anubi3,5-dichloroacetophenone
CBNumber:
CB0423917
Molecular Formula:
C8H7Cl2NO
Molecular Weight:
204.05
MDL Number:
MFCD00238535
MOL File:
37148-48-4.mol
MSDS File:
SDS
Last updated:2026-05-27 22:43:00
Request For Quotation

4-Amino-3,5-dichloroacetophenone Properties

Melting point 162-166 °C(lit.)
Boiling point 351.5±42.0 °C(Predicted)
Density 1.2748 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka -1.72±0.10(Predicted)
color Light Tan to Brown
InChI InChI=1S/C8H7Cl2NO/c1-4(12)5-2-6(9)8(11)7(10)3-5/h2-3H,11H2,1H3
InChIKey JLPKZJDZXIKSCP-UHFFFAOYSA-N
SMILES C(=O)(C1=CC(Cl)=C(N)C(Cl)=C1)C
CAS DataBase Reference 37148-48-4(CAS DataBase Reference)
FDA UNII EC3RI6O2DB
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
HS Code  29223990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

4-Amino-3,5-dichloroacetophenone price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 536148 4′-Amino-3′,5′-dichloroacetophenone 97% 37148-48-4 25g $299 2026-04-30 Buy
TCI Chemical A1967 4'-Amino-3',5'-dichloroacetophenone >98.0%(GC) 37148-48-4 5g $103 2026-04-30 Buy
TCI Chemical A1967 4'-Amino-3',5'-dichloroacetophenone >98.0%(GC) 37148-48-4 25g $294 2026-04-30 Buy
TRC TRC-A604690-500MG 1-(4-Amino-3,5-dichlorophenyl)-2-ethanone 37148-48-4 500mg $80 2026-06-03 Buy
TRC TRC-A604690-1G 1-(4-Amino-3,5-dichlorophenyl)-2-ethanone 37148-48-4 1g $108 2026-06-03 Buy
Product number Packaging Price Buy
536148 25g $299 Buy
A1967 5g $103 Buy
A1967 25g $294 Buy
TRC-A604690-500MG 500mg $80 Buy
TRC-A604690-1G 1g $108 Buy

4-Amino-3,5-dichloroacetophenone Chemical Properties, Uses, Production

Description

 4-Amino-3,5-dichloroacetophenone is an intermediate in the synthesis of the antitussive and antiasthmatic drug gramtin.

Storage

4-Amino-3,5-dichloroacetophenone should be stored in a cool, dry place in a small, well filled, well-closed container, protected from light. When a partially filled container is used, the air should be replaced by nitrogen or another inert gas.
4-Amino-3,5-dichloroacetophenone oxidizes on exposure to air, resulting in an increase in the peroxide value.

Chemical Properties

4-Amino-3,5-dichloroacetophenone is a white to light yellow crystal powder. Insoluble in cold water, slightly soluble in hot water.

Uses

4-Amino-3,5-dichloroacetophenone is used to synthesize the drug Clenbuterol. Clenbuterol is a steroid-like chemical that was initially developed to treat asthma in horses, working by relaxing the airways in the animals'lungs.

Preparation

4-Amino-3,5-dichloroacetophenone was synthesized by chlorination of 4-aminoacetophenone. Add 4-aminoacetophenone and acetic acid (80%) into the reaction pot, stir and dissolve, quickly add chlorine-containing glacial acetic acid solution, the temperature of the addition is 5°C. After the addition is completed, immediately put into ice water to precipitate, filter, and wash with water to obtain the crude product. Recrystallize with ethanol to obtain the finished product of 4-Amino-3,5-dichloroacetophenone.

Application

4-Amino-3,5-dichloroacetophenone is a compound useful in organic synthesis.

Application

4-Amino-3,5-dichloroacetophenone has active chemical properties and has been widely used in industrial chemistry, agricultural chemistry, and pharmaceutical chemistry. As a selective oxidant and green coupling reagent, it participates in a variety of oxidation reactions, rearrangement reactions, and amination reactions. In industry, it can also be used as a raw material for the synthesis of drugs, disinfectants, dyes, food seasonings, adhesives, explosives, etc.

Synthesis

Acetyl chloride

75-36-5

2,6-Dichloroaniline

608-31-1

4-Amino-3,5-dichloroacetophenone

37148-48-4

To a 250 mL three-necked flask was added 8.3 g of 2,6-dichloroaniline, 50 mL of chloroform was added and stirred to disperse, then 30 g of ferric chloride was added. The temperature of the reaction system was controlled at 0 °C and 8.8 g of acetyl chloride was added dropwise. After the dropwise addition, the reaction was continued to be stirred at room temperature for 6 hours. After completion of the reaction, the reaction solution was acidified, filtration was carried out and the resulting solid was washed with water to give 9.0 g of light yellow 3,5-dichloro-4-aminoacetophenone in 88.6% yield. The purity of the product was 99.5% by HPLC.

References

[1] Patent: CN105968021, 2016, A. Location in patent: Paragraph 0168-0169

4-Amino-3,5-dichloroacetophenone synthesis

75-36-5
608-31-1
37148-48-4
Synthesis of 4-Amino-3,5-dichloroacetophenone from Acetyl chloride and 2,6-Dichloroaniline

4-Amino-3,5-dichloroacetophenone Preparation Products And Raw materials

Raw materials

Acetic acid 4-Aminoacetophenone Acetic anhydride Chlorine Acetyl chloride
2,6-Dichloroaniline Ferric chloride Chloroform 2,4,6-Trichloroaniline

1of2

Preparation Products

4-Amino-3,5-dichlorophenacylbromide 4-Amino-alpha-tert-butylamine-3,5-dichloroacetophenone 1-(4-Amino-3-chloro-phenyl)-ethanone Clenbuterol hydrochloride 3,4,5-Trichloro-benzoicacid
3',5'-Dichloroacetophenone

1of2

4-Amino-3,5-dichloroacetophenone Suppliers

Global Suppliers ( 419)
Supplier Tel Email Country ProdList Advantage
Shandong Chenyi Environmental Protection Technology Co., Ltd 0531-83179999 13395316108 cyhbkjyxgs@163.com China 196 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
Shandong Chenyi Environmental Protection Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66
Adamas Reagent, Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64

Related articles

View Latest Price from 4-Amino-3,5-dichloroacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Amino-3,5-dichloroacetophenone pictures 2026-09-14 4-Amino-3,5-dichloroacetophenone
37148-48-4
 $1.00 1G 99.9% 5000KG .GZ HONESTCHEM CO.,LTD
1-(4-Amino-3,5-dichlorophenyl)ethanone pictures 2026-09-14 1-(4-Amino-3,5-dichlorophenyl)ethanone
$1.00 1G 99.9% 5000KG .GZ HONESTCHEM CO.,LTD
4’-Amino-3’,5’-dichloroacetophenone pictures 2026-09-14 4’-Amino-3’,5’-dichloroacetophenone
$1.00 1G 99.9% 5000KG .GZ HONESTCHEM CO.,LTD

4-Amino-3,5-dichloroacetophenone Spectrum

4-Amino-3,5-dichloroacetophenone(37148-48-4)1HNMR

37148-48-4 (4-Amino-3,5-dichloroacetophenone) Related Search:

2',5'-Dichloroacetophenone 4'-Hydroxyacetophenone 4-Nitroacetophenone 3-Aminoacetophenone Acetyl chloride
Dichloroacetonitrile 2-Aminoecetophenone 2-Bromoacetophenone 3-Nitroacetophenone Betaine
L-PICEIN Acetylacetone 4'-Methylacetophenone Acetophenone Glycine
Aminoethoxyvinyl glycine hydrochloride 4'-Dimethylaminoacetophenone 3'-Dimethylaminoacetophenone

1of4

1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone 1-(4-Amino-3,5-dichloro-phenyl)-2-ethanone 5-AMINO-3,5-DICHLORO ACETOPHENONE 4''-AMINO-3'',5''-DICHLOROACETOPHENONECLENBUTEROL 4-Amino-3,5-dichloroacetophenone,98% 4′-Amino-3′,5′-dichloroacetophenone,1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone 3,5-dichloro-p-aMino acetophenone 4-AMino-3,5-dichloroacetophenone, 98% 5GR 4'-AMino-3',5'-dichloroacetophenone SynonyMs 4-Acetyl-2,6-dichloroaniline 4'-Amino-3',5'-dichloroacetophenone 97% TIMTEC-BB SBB003511 1-(4-AMINO-3,5-DICHLOROPHENYL)-ETHANONE 4-AMINO-3,5-DICHLOROACETOPHENONE 4-ACETYL-2,6-DICHLOROANILINE Clenbuterol Impurity 3（Clenbuterol EP Impurity C） Clenbuterol EP Impurity C 4-Anubi3,5-dichloroacetophenone 4-Amino-3,5-dichloroacetophenone CAS: 37148-48-4 CAS 37148-48-4 4-Amino-3,5-dichloroacetophenone High Quality 4-Amino-3, 5-Dichloroacetophenone 4'-Amino-3',5'-dichloroacetophenone > Ethanone, 1-(4-amino-3,5-dichlorophenyl)- Bromo-1-Phenyl-Pentan-1-One 2-Bromovalerophenone Yellow Liquid CAS Pharmaceutical Chemical 2-Bromo-4′-Methylpropiophenone 99% Purity 2-Bromo-1-Phenyl-Pentan-1-One 5-dichlorophenyl)- 3,5-dichloro-4-amino 4-Amino-3,5-dichloroacetophenone Basic information 1-(4-Amino-3,5-dichlorphenyl)ethan-1-on 3, 5-dichloro-4-aminophenone 4'-Amino-3',5'-dichloroacetophenone 1-(4-amino-3,5-dichlorophenyl)ethan-1-one 3,5-DICHLORO-4-AMINOACETOPHENONE 37148-48-4 H2NC6H2Cl2COCH3 Organic Building Blocks Ketones C7 to C8 Carbonyl Compounds Building Blocks Chemical Amines Amines Aromatics Aromatic Acetophenones & Derivatives (substituted) (intermediate of leflunomide) 37148-48-4