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(4-Fluorophenyl)acetone

(4-Fluorophenyl)acetone structure

CAS No.: 459-03-0

Chemical Name:: (4-Fluorophenyl)acetone

Synonyms: cas 459-03-0;2-Propanone, 1-(4;4-FLUOROPHENYLACETONE;4'-FLUOROPHENYLACETONE;(P-FLUOROPHENYL)ACETONE;4-Fluorophenylacetone98%;4-Fluorophenylacetone 98%;4-Fluorophenylacetone,99%;1-(4-Fluorophenyl)acetone;4-Fluorophenylacetone pmk

CBNumber:: CB0459004

Molecular Formula:: C9H9FO

Molecular Weight:: 152.17

MDL Number:: MFCD00000362

MOL File:: 459-03-0.mol

MSDS File:: SDS

Last updated:2026-01-13 11:12:25

Product description	Number	Pack Size	Price
(4-Fluorophenyl)acetone 98%	209457	10g	$269
4-Fluorophenylacetone >98.0%(GC)	F0535	5g	$26
4-Fluorophenylacetone >98.0%(GC)	F0535	25g	$101
4'-Fluorophenylacetone 98%	2617-3-16	25g	$135
4-Fluorophenylacetone 97%	003899	25g	$54
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(4-Fluorophenyl)acetone Properties

Boiling point	106-107 °C/18 mmHg (lit.)
Density	1.139 g/mL at 25 °C (lit.)
refractive index	n20/D 1.496(lit.)
Flash point	197 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Methyl Acetate: 50 mg/ml
form	clear liquid
Specific Gravity	1.139
color	Light yellow to Yellow to Orange
Water Solubility	insoluble
BRN	1936697
InChI	InChI=1S/C9H9FO/c1-7(11)6-8-2-4-9(10)5-3-8/h2-5H,6H2,1H3
InChIKey	ZUEKIIWSVFBTCM-UHFFFAOYSA-N
SMILES	C(C1=CC=C(F)C=C1)C(=O)C
CAS DataBase Reference	459-03-0(CAS DataBase Reference)
NIST Chemistry Reference	(4-Fluorophenyl)acetone(459-03-0)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H227

Precautionary statements

P210-P280-P403+P235-P501-P210e-P280a-P370+P378a-P501a

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

F,Xi

Risk Statements

36/37/38

Safety Statements

24/25

WGK Germany

Hazard Note

Flammable

HazardClass

IRRITANT, FLAMMABLE

HS Code

29147090

Storage Class

10 - Combustible liquids

NFPA 704

	2
0		0

(4-Fluorophenyl)acetone price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	209457	(4-Fluorophenyl)acetone 98%	459-03-0	10g	$269	2025-07-31	Buy
TCI Chemical	F0535	4-Fluorophenylacetone >98.0%(GC)	459-03-0	5g	$26	2025-07-31	Buy
TCI Chemical	F0535	4-Fluorophenylacetone >98.0%(GC)	459-03-0	25g	$101	2025-07-31	Buy
SynQuest Laboratories	2617-3-16	4'-Fluorophenylacetone 98%	459-03-0	25g	$135	2021-12-16	Buy
Matrix Scientific	003899	4-Fluorophenylacetone 97%	459-03-0	25g	$54	2021-12-16	Buy

Product number	Packaging	Price	Buy
209457	10g	$269	Buy
F0535	5g	$26	Buy
F0535	25g	$101	Buy
2617-3-16	25g	$135	Buy
003899	25g	$54	Buy

(4-Fluorophenyl)acetone Chemical Properties,Uses,Production

Description

This intermediate, also known as (4-Fluorophenyl)acetone, presents as a dark yellow liquid. It is known to be insoluble in water. For best results, store in a tightly closed container in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. 4-Fluorophenylacetone is incompatible with strong oxidizing agents. This chemical is a combustible liquid.

Chemical Properties

clear yellow liquid

Uses

4-Fluorophenylacetone is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields. It is a haloarylacetone derivative used in a study of reversed enantiopreference of an ω-transaminase by a single-point mutation.

Application

(4-Fluorophenyl)acetone is a phenylacetic acid derivative that inhibits the 5-HT2 receptors. It has been shown to have inhibitory activities against dopamine and serotonin by acting as an agonist at the receptor. (4-Fluorophenyl)acetone also binds to nucleophilic sites on proteins, which may lead to inhibition of protein synthesis. Brevibacterium sp. strain P7 was used as a model system and it has found that it inhibited the growth of this bacterium by binding to the enzyme RNA polymerase, preventing transcription and replication.

Synthesis

4-Fluorophenyl acetone synthesis methods are mainly the following: (1) 4-fluorophenyl derivatives and acetone in the presence of catalysts such as manganese acetate to obtain; (2) -cyanoacetone-based m-fluorobenzene and sulfuric acid reaction can also be obtained; (3) by the starting material m-fluorotoluene through the side chain of bromination, hydrolysis to obtain m-fluorobenzaldehyde, and then after the addition of reaction with nitroethane and hydrolysis to obtain.

(4-Fluorophenyl)acetone synthesis

Synthesis of (4-Fluorophenyl)acetone from Methyllithium and 4-Fluorophenylacetic acid

(4-Fluorophenyl)acetone Preparation Products And Raw materials

Raw materials

2-Propanone, 1-fluoro-1-phenyl- 3-Fluorophenylacetone 2-Fluorophenylacetone Phenylacetone Fluorobenzene

Acetone

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Preparation Products

(4-Fluorophenyl)acetone Suppliers

Global( 272)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Aoliqisi New Material Technology Co., Ltd.	+86-13545906766; +8613545906766	sales@whaop.com	China	263	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
Xiamen Wonderful Bio Technology Co., Ltd.	+8613043004613	Sara@xmwonderfulbio.com	China	283	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	Brad@rongnabiotech.com	China	3378	58
Hubei Aumei New Material Co., Ltd.	+86-027-87366298 +8615927270571	tianyi@skbiology.cn	China	282	58
Firsky International Trade (Wuhan) Co., Ltd	+8615387054039	admin@firsky-cn.com	China	427	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Hebei Ganmiao New material Technology Co., LTD	+86-17332992504	sales8@hbganmiao.com	China	300	58
HebeiShuoshengImportandExportco.,Ltd	+86-18532138899	L18532138899@163.com	China	939	58

Supplier	Advantage
Wuhan Aoliqisi New Material Technology Co., Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
Xiamen Wonderful Bio Technology Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
RongNa Biotechnology Co.,Ltd	58
Hubei Aumei New Material Co., Ltd.	58
Firsky International Trade (Wuhan) Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Hebei Ganmiao New material Technology Co., LTD	58
HebeiShuoshengImportandExportco.,Ltd	58

View Lastest Price from (4-Fluorophenyl)acetone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-15	4-Fluorophenylacetone 459-03-0	US $10.00 / ASSAYS	1ASSAYS	99%	10 ton	RongNa Biotechnology Co.,Ltd
2026-01-30	4-Fluorophenylacetone 459-03-0	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2026-01-19	(4-Fluorophenyl)acetone 459-03-0	US $0.00 / kg	1kg	0.99	10T	Shandong Hanjiang Chemical Co., Ltd

4-Fluorophenylacetone
459-03-0
US $10.00 / ASSAYS
99%
RongNa Biotechnology Co.,Ltd

4-Fluorophenylacetone
459-03-0
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

(4-Fluorophenyl)acetone
459-03-0
US $0.00 / kg
0.99
Shandong Hanjiang Chemical Co., Ltd

(4-Fluorophenyl)acetone Spectrum

4-Fluorophenylacetone(459-03-0)MS 4-Fluorophenylacetone(459-03-0)¹HNMR 4-Fluorophenylacetone(459-03-0)¹³CNMR 4-Fluorophenylacetone(459-03-0)IR1 4-Fluorophenylacetone(459-03-0)Raman

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