2-Chloro-4-fluoronitrobenzene
- CAS No.
- 2106-50-5
- Chemical Name:
- 2-Chloro-4-fluoronitrobenzene
- Synonyms
- 2-chloro-4-fluoro-1-nitrobenzene;2-CHLORO-4-FLUORONITROBENZENE;4-fluoro-2-chloronitrobenzene;2-chloro-4-fluoronitrobenzenen;1-Chloro-5-fluoro-2-nitroBenzene;3-Chloro-1-fluoro-4-nitrobenzene;2-Chloro-4-fluoronitrobenzene >2-CHLORO-4-FLUORONITROBENZENE 98%;Benzene, 2-chloro-4-fluoro-1-nitro-;2-chloro-4-fluoronitrobenzen, 98%min
- CBNumber:
- CB1494826
- Molecular Formula:
- C6H3ClFNO2
- Molecular Weight:
- 175.54
- MDL Number:
- MFCD03412200
- MOL File:
- 2106-50-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 34-37°C |
|---|---|
| Boiling point | 71°C/2.3mmHg(lit.) |
| Density | 1.494±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| form | Solid |
| color | Light Yellow |
| InChI | InChI=1S/C6H3ClFNO2/c7-5-3-4(8)1-2-6(5)9(10)11/h1-3H |
| InChIKey | KQOOFMWRLDRDAX-UHFFFAOYSA-N |
| SMILES | C1([N+]([O-])=O)=CC=C(F)C=C1Cl |
| CAS DataBase Reference | 2106-50-5(CAS DataBase Reference) |
| FDA UNII | HZL4Q2H59S |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H302-H311 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501-P280h-P305+P351+P338-P309-P310 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38-36/38-21/22 | |||||||||
| Safety Statements | 26-36/37/39-36/37 | |||||||||
| RIDADR | 2811 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29049090 | |||||||||
| NFPA 704 |
|
2-Chloro-4-fluoronitrobenzene price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2615 | 2-Chloro-4-fluoronitrobenzene >98.0%(GC) | 2106-50-5 | 5g | $77 | 2026-04-30 | Buy |
| TCI Chemical | C2615 | 2-Chloro-4-fluoronitrobenzene >98.0%(GC) | 2106-50-5 | 25g | $305 | 2026-04-30 | Buy |
| TRC | TRC-C585068-500MG | 2-Chloro-4-fluoro-1-nitrobenzene | 2106-50-5 | 500mg | $84 | 2026-06-03 | Buy |
| Apolloscientific | PC1336 | 2-Chloro-4-fluoronitrobenzene ≥95% | 2106-50-5 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC1336 | 2-Chloro-4-fluoronitrobenzene ≥95% | 2106-50-5 | 5g | $24 | 2026-06-04 | Buy |
2-Chloro-4-fluoronitrobenzene Chemical Properties, Uses, Production
Uses
2-Chloro-4-fluoronitrobenzene is used in the synthesis of active pharmaceutical ingredients (APIs), particularly benzothiazole derivatives.
Synthesis
625-98-9
2106-50-5
(a) 3-Chlorofluorobenzene (240 g, 1.85 mol) was slowly added to a mixture of sulfuric acid (185 g, 1.85 mol) and nitric acid (166 g, 1.85 mol) pre-cooled to -5°C. The reaction was carried out at the same temperature for 13 hours. The reaction temperature was maintained at -5°C with continuous stirring for 3.5 hours, followed by continued stirring at the same temperature for 13 hours. Upon completion of the reaction, benzene (200 mL) and hexane (200 mL) were added to the reaction mixture for extraction. The organic phases were combined and washed sequentially with water (300 mL), sodium carbonate solution (300 mL) and water (300 mL). The organic layer was dried over anhydrous sodium sulfate and the solvent was removed by distillation under reduced pressure. The residue was purified by distillation to give 138 g of the mixed isomer. The 4-nitro isomer was isolated from the mixed isomer by crystallization and filtered to give 3-chloro-4-nitrofluorobenzene (51 g, 16.7% yield) with a melting point of 36°C-38°C.
References
[1] Patent: US4330324, 1982, A
[2] Patent: US31455, 1983, E1
[3] Patent: US4358308, 1982, A
[4] Patent: US4419122, 1983, A
[5] Patent: US4419123, 1983, A
2-Chloro-4-fluoronitrobenzene Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing XiLang Chemical Products Co., Ltd. | 18936048580 | chemxilang@163.com | China | 3909 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Latest Price from 2-Chloro-4-fluoronitrobenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | 2-Chloro-4-fluoronitrobenzene
2106-50-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-14 | 2-Chloro-4-fluoronitrobenzene
2106-50-5
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 2-Chloro-4-fluoronitrobenzene
2106-50-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-Chloro-4-fluoronitrobenzene
2106-50-5
- $1.00
- 99%
- Career Henan Chemical Co
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