4-(Morpholinomethyl)benzoic acid
- CAS No.
- 62642-62-0
- Chemical Name:
- 4-(Morpholinomethyl)benzoic acid
- Synonyms
- AKOS BB-9472;BUTTPARK 98\57-92;TIMTEC-BB SBB011465;4-(Morpholinomethyl)benzoic acid;4-MORPHOLIN-4-YLMETHYLBENZOIC ACID;4-(4-Morpholinemethyl)benzoic acid;4-(4-Morpholinylmethyl)benzoic acid;4-MORPHOLIN-4-YLMETHYLBENZOIC ACID 95%;Benzoic acid, 4-(4-morpholinylmethyl)-;4-(4-Morpholinylmethyl)benzoic acid, 97%
- CBNumber:
- CB0747079
- Molecular Formula:
- C12H15NO3
- Molecular Weight:
- 221.25
- MDL Number:
- MFCD01167722
- MOL File:
- 62642-62-0.mol
- MSDS File:
- SDS
| Melting point | 179-183°C |
|---|---|
| Boiling point | 369.8±32.0 °C(Predicted) |
| Density | 1.233±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.00±0.10(Predicted) |
| color | Off-White to Beige |
| Sensitive | Hygroscopic |
| CAS DataBase Reference | 62642-62-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2916310090 | |||||||||
| NFPA 704 |
|
4-(Morpholinomethyl)benzoic acid price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M725180-5G | 4-(Morpholinomethyl)benzoic Acid | 62642-62-0 | 5g | $139 | 2026-06-03 | Buy |
| TRC | TRC-M725180-1G | 4-(Morpholinomethyl)benzoic Acid | 62642-62-0 | 1g | $65 | 2026-06-03 | Buy |
| Apolloscientific | OR346277 | 4-[(Morpholin-4-yl)methyl]benzoic acid 98% | 62642-62-0 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR346277 | 4-[(Morpholin-4-yl)methyl]benzoic acid 98% | 62642-62-0 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR346277 | 4-[(Morpholin-4-yl)methyl]benzoic acid 98% | 62642-62-0 | 5g | $85 | 2026-06-04 | Buy |
4-(Morpholinomethyl)benzoic acid Chemical Properties,Uses,Production
Uses
4-(Morpholinomethyl)benzoic Acid is a reactant used in the synthesis of sirtuin 2 inhibitors, used in the treatment of parkinsons.
Synthesis
68453-56-5
62642-62-0
General procedure for the synthesis of 4-morpholinomethylbenzoic acid from methyl 4-(morpholinomethyl)benzoate: to a stirred solution of methyl 4-(morpholinomethyl)benzoate (4.0 g, 17.0020 mmol, 1.0 eq.) in methanol (40 mL) was added slowly at 0 °C an aqueous 1N NaOH solution (136.0 mL, 136.0 mmol, 8.0 equivalent). The reaction mixture was stirred at room temperature overnight. The progress of the reaction was monitored by TLC and after confirming the completion of the reaction, the reaction mixture was cooled to 0 °C and neutralized with 1N HCl to pH neutral. Subsequently, the solvent was removed by evaporation under reduced pressure. Methanol (40 mL) and dichloromethane (60 mL) were added to the resulting solid and stirred at room temperature for 25 minutes. The mixture was filtered and the filtrate was evaporated under reduced pressure to recover the product. The above extraction and evaporation process was repeated twice to finally obtain a white solid product (3.0 g, yield: 79.57%), which could be used in the next reaction without further purification. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3) and ESI-MS: 1H NMR δ 8.04 (d, J = 8.1 Hz, 2H), 7.50 (d, J = 8.1 Hz, 2H), 3.81 (m, 4H), 3.71 (s, 2H), 2.62 (m, 4H); ESI-MS: m/z 222.01 (M + H)+.
References
[1] Patent: WO2018/29604, 2018, A1. Location in patent: Page/Page column 45
[2] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 2, p. 179 - 190
4-(Morpholinomethyl)benzoic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
4-(Morpholinomethyl)benzoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
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| Shanghai Xiannuo Biotechnology Co., Ltd. | 021-50718719 13918719472 | China | 978 | 58 | |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. | +86-28-85122536 85324413 | market@astatech.cn | China | 8016 | 55 |
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