ChemicalBook >> CAS DataBase List >>2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)-

2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)-

2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)- structure

CAS No.: 2415941-98-7

Chemical Name:: 2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)-

Synonyms: FAP-PI3KI1;2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)-

CBNumber:: CB110253284

Molecular Formula:: C52H48F4N10O12S3

Molecular Weight:: 1177.19

MDL Number:

MOL File:: 2415941-98-7.mol

Last updated:2025-04-18 09:51:35

Request For Quotation

2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)- Properties

Density	1.56±0.1 g/cm3(Predicted)
pka	3.13±0.10(Predicted)

2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)- Chemical Properties, Uses, Production

Uses

FAP-PI3KI1 is a fibroblast-activated protein (FAP)-targeted PI3K inhibitor that selectively targets FAP-expressing human idiopathic pulmonary fibrosis (IPF) cells and effectively inhibits collagen synthesis and reduces collagen deposition[1].

References

[1] Suraj U Hettiarachchi, et al. Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models. Sci Transl Med. 2020 Oct 28;12(567):eaay3724. DOI:10.1126/scitranslmed.aay3724

2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)- Suppliers

Global Suppliers ( 2)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanchang Tianzhen Biotechnology Co., Ltd	13758194781 13173652190	522013271@qq.com	China	2436	58
Fuan Bio	15002819872	2845971812@qq.com	China	2103	58

Supplier	Advantage
Nanchang Tianzhen Biotechnology Co., Ltd	58
Fuan Bio	58

2415941-98-7 (2-Oxa-5,6-dithia-9,14-diazapentadecanoic acid, 8-carboxy-15-[4-[[[(1S)-2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-1-methyl-2-oxoethyl]amino]carbonyl]-2-pyridinyl]-10,13-dioxo-, 1-[[5-[6-[5-[[(2,4-difluorophenyl)sulfonyl]amino]-6-methoxy-3-pyridinyl]-4-quinolinyl]-2-pyridinyl]methyl] ester, (8R)-) Related Search:

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