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2-Chloro-4-hydroxybenzonitrile

2-Chloro-4-hydroxybenzonitrile Structure
2-Chloro-4-hydroxybenzonitrile structure
CAS No.
3336-16-1
Chemical Name:
2-Chloro-4-hydroxybenzonitrile
Synonyms
3-Chloro-4-cyanophenol;Chloro-4-hydroxybenzonitrile;2-Chloro-4-hydroxybenzonitrile;Benzonitrile,2-chloro-4-hydroxy-;2-Chloro-4-hydroxybenzonitrile 98%;2-Chloro-4-hydroxybenzonitrile 98+%
CBNumber:
CB1110443
Molecular Formula:
C7H4ClNO
Molecular Weight:
153.57
MDL Number:
MFCD00052185
MOL File:
3336-16-1.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:35
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2-Chloro-4-hydroxybenzonitrile Properties

Melting point 160 °C (dec.)(lit.)
Boiling point 323.2±27.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 6.88±0.18(Predicted)
form powder
color White
InChI 1S/C7H4ClNO/c8-7-3-6(10)2-1-5(7)4-9/h1-3,10H
InChIKey BDDVAWDNVWLHDQ-UHFFFAOYSA-N
SMILES Oc1ccc(C#N)c(Cl)c1
CAS DataBase Reference 3336-16-1
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-37/39
WGK Germany  3
HS Code  2926907090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

2-Chloro-4-hydroxybenzonitrile price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 346071 2-Chloro-4-hydroxybenzonitrile 98% 3336-16-1 5g $182 2023-06-20 Buy
Sigma-Aldrich 346071 2-Chloro-4-hydroxybenzonitrile 98% 3336-16-1 10g $325 2023-06-20 Buy
Biosynth FC70259 2-Chloro-4-hydroxybenzonitrile 3336-16-1 50g $150 2026-06-04 Buy
Biosynth FC70259 2-Chloro-4-hydroxybenzonitrile 3336-16-1 25g $150 2026-06-04 Buy
Biosynth FC70259 2-Chloro-4-hydroxybenzonitrile 3336-16-1 100g $228 2026-06-04 Buy
Product number Packaging Price Buy
346071 5g $182 Buy
346071 10g $325 Buy
FC70259 50g $150 Buy
FC70259 25g $150 Buy
FC70259 100g $228 Buy

2-Chloro-4-hydroxybenzonitrile Chemical Properties, Uses, Production

Uses

2-Chloro-4-hydroxybenzonitrile is used for preparation of arylthioamides.

Chemical Properties

white to light yellow crystal powder

Uses

2-Chloro-4-hydroxybenzonitrile may be used in the synthesis of 6-aminophenanthridines via Suzuki-Miyaura coupling reaction. It may be used in the preparation of 5-bromo-2-chloro-4-hydroxybenzonitrile.

Synthesis

4-Amino-2-chlorobenzonitrile

20925-27-3

2-CHLORO-4-HYDROXYBENZONITRILE

3336-16-1

Step 5: 2-Chloro-4-aminobenzonitrile (25 g, 0.187 mol) was added to a stirred mixture of concentrated sulfuric acid (58 g) and water (570 mL) and heated between 49 °C and 61 °C for about 30 minutes. The suspension was cooled to about 0°C and a cold solution of sodium nitrite (13.2 g, 0.187 mol) dissolved in water (125 mL) was slowly added dropwise over a temperature range of 0°C to 6°C. After the dropwise addition was completed, stirring of the reaction mixture was continued for about 3 hours. Subsequently, urea (1.5 g) was added to the mixture to quench the excess sodium nitrite. Insoluble impurities were removed by filtration. To the filtrate was added a 50% aqueous sulfuric acid solution (600 mL) while the reaction mixture was heated to between 74 °C and 81 °C with continuous stirring until the nitrogen stopped escaping. Upon completion of the reaction, the product was separated by filtration and purified with recrystallized water to give 2-chloro-4-hydroxybenzonitrile (17.9 g, 62.5% yield, melting point 160 °C).

References

[1] Patent: US4424371, 1984, A

2-Chloro-4-hydroxybenzonitrile synthesis

20925-27-3
3336-16-1
Synthesis of 2-Chloro-4-hydroxybenzonitrile from 4-Amino-2-chlorobenzonitrile

2-Chloro-4-hydroxybenzonitrile Preparation Products And Raw materials

Raw materials

4-Amino-2-chlorobenzonitrile Urea Water Sodium nitrite Sulfuric acid

Preparation Products

2-Chloro-4-hydroxy-benzoic acid methyl ester 4-Benzyloxy-3-chloro-benzonitrile Ethyl 2-chloro-4-hydroxybenzoate

2-Chloro-4-hydroxybenzonitrile Suppliers

Global Suppliers ( 122)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Wuhan Arike Technology Co., Ltd. 027- 51832457 94518350 China 746 62
Supplier Advantage
J & K SCIENTIFIC LTD. 76
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
Capot Chemical Co., Ltd 66
Jia Xing Isenchem Co.,Ltd 66
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57
Wuhan Arike Technology Co., Ltd. 62

View Latest Price from 2-Chloro-4-hydroxybenzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-CHLORO-4-HYDROXYBENZONITRILE pictures 2026-03-20 2-CHLORO-4-HYDROXYBENZONITRILE
3336-16-1
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
2-CHLORO-4-HYDROXYBENZONITRILE pictures 2024-07-11 2-CHLORO-4-HYDROXYBENZONITRILE
3336-16-1
 $1.00 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
2-CHLORO-4-HYDROXYBENZONITRILE pictures 2019-07-06 2-CHLORO-4-HYDROXYBENZONITRILE
3336-16-1
 $1.00 1KG 99% 1ton Career Henan Chemical Co

2-Chloro-4-hydroxybenzonitrile Spectrum

2-CHLORO-4-HYDROXYBENZONITRILE(3336-16-1)1HNMR2-CHLORO-4-HYDROXYBENZONITRILE(3336-16-1)FT-IR

3336-16-1 (2-Chloro-4-hydroxybenzonitrile) Related Search:

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Chloro-4-hydroxybenzonitrile Benzonitrile,2-chloro-4-hydroxy- 2-Chloro-4-hydroxybenzonitrile 98+% 3-Chloro-4-cyanophenol 2-Chloro-4-hydroxybenzonitrile 98% 2-Chloro-4-hydroxybenzonitrile 3336-16-1 ClC6H3OHCN C6 to C7 Building Blocks Cyanides/Nitriles Nitrogen Compounds Organic Building Blocks Aromatic Nitriles C6 to C7 Cyanides/Nitriles Nitrogen Compounds