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2-CHLORO-4-HYDROXYBENZONITRILE

2-CHLORO-4-HYDROXYBENZONITRILE Structure
2-CHLORO-4-HYDROXYBENZONITRILE structure
CAS No.
3336-16-1
Chemical Name:
2-CHLORO-4-HYDROXYBENZONITRILE
Synonyms
3-Chloro-4-cyanophenol;Chloro-4-hydroxybenzonitrile;2-CHLORO-4-HYDROXYBENZONITRILE;Benzonitrile,2-chloro-4-hydroxy-;2-Chloro-4-hydroxybenzonitrile 98%;2-Chloro-4-hydroxybenzonitrile 98+%
CBNumber:
CB1110443
Molecular Formula:
C7H4ClNO
Molecular Weight:
153.57
MDL Number:
MFCD00052185
MOL File:
3336-16-1.mol
MSDS File:
SDS
Last updated:2026-05-27 23:03:22
Product description Number Pack Size Price
2-Chloro-4-hydroxybenzonitrile 98% 346071 5g $182
2-Chloro-4-hydroxybenzonitrile 98% 346071 10g $325
2-Chloro-4-hydroxybenzonitrile FC70259 50g $150
2-Chloro-4-hydroxybenzonitrile FC70259 25g $150
2-Chloro-4-hydroxybenzonitrile FC70259 100g $228
More product size
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2-CHLORO-4-HYDROXYBENZONITRILE Properties

Melting point 160 °C (dec.)(lit.)
Boiling point 323.2±27.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 6.88±0.18(Predicted)
form powder
color White
InChI 1S/C7H4ClNO/c8-7-3-6(10)2-1-5(7)4-9/h1-3,10H
InChIKey BDDVAWDNVWLHDQ-UHFFFAOYSA-N
SMILES Oc1ccc(C#N)c(Cl)c1
CAS DataBase Reference 3336-16-1
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-37/39
WGK Germany  3
HS Code  2926907090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

2-CHLORO-4-HYDROXYBENZONITRILE price More Price(62)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 346071 2-Chloro-4-hydroxybenzonitrile 98% 3336-16-1 5g $182 2023-06-20 Buy
Sigma-Aldrich 346071 2-Chloro-4-hydroxybenzonitrile 98% 3336-16-1 10g $325 2023-06-20 Buy
Biosynth FC70259 2-Chloro-4-hydroxybenzonitrile 3336-16-1 50g $150 2026-06-04 Buy
Biosynth FC70259 2-Chloro-4-hydroxybenzonitrile 3336-16-1 25g $150 2026-06-04 Buy
Biosynth FC70259 2-Chloro-4-hydroxybenzonitrile 3336-16-1 100g $228 2026-06-04 Buy
Product number Packaging Price Buy
346071 5g $182 Buy
346071 10g $325 Buy
FC70259 50g $150 Buy
FC70259 25g $150 Buy
FC70259 100g $228 Buy

2-CHLORO-4-HYDROXYBENZONITRILE Chemical Properties,Uses,Production

Uses

2-Chloro-4-hydroxybenzonitrile is used for preparation of arylthioamides.

Chemical Properties

white to light yellow crystal powder

Uses

2-Chloro-4-hydroxybenzonitrile may be used in the synthesis of 6-aminophenanthridines via Suzuki-Miyaura coupling reaction. It may be used in the preparation of 5-bromo-2-chloro-4-hydroxybenzonitrile.

Synthesis

4-Amino-2-chlorobenzonitrile

20925-27-3

2-CHLORO-4-HYDROXYBENZONITRILE

3336-16-1

Step 5: 2-Chloro-4-aminobenzonitrile (25 g, 0.187 mol) was added to a stirred mixture of concentrated sulfuric acid (58 g) and water (570 mL) and heated between 49 °C and 61 °C for about 30 minutes. The suspension was cooled to about 0°C and a cold solution of sodium nitrite (13.2 g, 0.187 mol) dissolved in water (125 mL) was slowly added dropwise over a temperature range of 0°C to 6°C. After the dropwise addition was completed, stirring of the reaction mixture was continued for about 3 hours. Subsequently, urea (1.5 g) was added to the mixture to quench the excess sodium nitrite. Insoluble impurities were removed by filtration. To the filtrate was added a 50% aqueous sulfuric acid solution (600 mL) while the reaction mixture was heated to between 74 °C and 81 °C with continuous stirring until the nitrogen stopped escaping. Upon completion of the reaction, the product was separated by filtration and purified with recrystallized water to give 2-chloro-4-hydroxybenzonitrile (17.9 g, 62.5% yield, melting point 160 °C).

References

[1] Patent: US4424371, 1984, A

2-CHLORO-4-HYDROXYBENZONITRILE synthesis

20925-27-3
3336-16-1
Synthesis of 2-CHLORO-4-HYDROXYBENZONITRILE from 4-Amino-2-chlorobenzonitrile

2-CHLORO-4-HYDROXYBENZONITRILE Preparation Products And Raw materials

Raw materials

4-Amino-2-chlorobenzonitrile Urea Water Sodium nitrite Sulfuric acid

Preparation Products

2-CHLORO-4-HYDROXY-BENZOIC ACID METHYL ESTER 4-BENZYLOXY-3-CHLORO-BENZONITRILE Ethyl 2-chloro-4-hydroxybenzoate

2-CHLORO-4-HYDROXYBENZONITRILE Suppliers

Global( 123)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 3957 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 9976 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Capot Chemical Co.,Ltd. 		60
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
career henan chemical co 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Fuxin Pharmaceutical 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58

View Lastest Price from 2-CHLORO-4-HYDROXYBENZONITRILE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-CHLORO-4-HYDROXYBENZONITRILE pictures 2026-03-20 2-CHLORO-4-HYDROXYBENZONITRILE
3336-16-1
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
2-CHLORO-4-HYDROXYBENZONITRILE pictures 2024-07-11 2-CHLORO-4-HYDROXYBENZONITRILE
3336-16-1
 $1.00 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
2-CHLORO-4-HYDROXYBENZONITRILE pictures 2019-07-06 2-CHLORO-4-HYDROXYBENZONITRILE
3336-16-1
 $1.00 1KG 99% 1ton Career Henan Chemical Co

2-CHLORO-4-HYDROXYBENZONITRILE Spectrum

2-CHLORO-4-HYDROXYBENZONITRILE(3336-16-1)1HNMR2-CHLORO-4-HYDROXYBENZONITRILE(3336-16-1)FT-IR

3336-16-1(2-CHLORO-4-HYDROXYBENZONITRILE)Related Search:

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2-CHLORO-4-HYDROXYBENZONITRILE Chloro-4-hydroxybenzonitrile Benzonitrile,2-chloro-4-hydroxy- 2-Chloro-4-hydroxybenzonitrile 98+% 3-Chloro-4-cyanophenol 2-Chloro-4-hydroxybenzonitrile 98% 3336-16-1 ClC6H3OHCN C6 to C7 Building Blocks Cyanides/Nitriles Nitrogen Compounds Organic Building Blocks Aromatic Nitriles C6 to C7 Cyanides/Nitriles Nitrogen Compounds