5,6-Dimethoxyindole
- CAS No.
- 14430-23-0
- Chemical Name:
- 5,6-Dimethoxyindole
- Synonyms
- 5,6-DIMETHOXY-1H-INDOLE;AKOS JY2083477;5,6-DIMETHOXYINDOLE;5,6-Dimethoxyindole,99%;5,6-Dimethoxyindole 99%;1H-Indole, 5,6-dimethoxy-;5,6-Dimethoxy-1H-indole99%;5,6-Dimethoxy-1H-indole 99%;5,6-dimethoxy-1H-indole - [D82930]
- CBNumber:
- CB1129065
- Molecular Formula:
- C10H11NO2
- Molecular Weight:
- 177.2
- MDL Number:
- MFCD00005675
- MOL File:
- 14430-23-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 154-157 °C (lit.) |
|---|---|
| Boiling point | 198°C 8mm |
| Density | 1.182±0.06 g/cm3(Predicted) |
| Flash point | 198°C/8mm |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 16.93±0.30(Predicted) |
| form | Powder |
| color | Beige |
| Water Solubility | Insoluble in water. |
| λmax | 306nm(EtOH)(lit.) |
| BRN | 5683 |
| InChI | InChI=1S/C10H11NO2/c1-12-9-5-7-3-4-11-8(7)6-10(9)13-2/h3-6,11H,1-2H3 |
| InChIKey | QODBZRNBPUPLEZ-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(OC)C(OC)=C2)C=C1 |
| CAS DataBase Reference | 14430-23-0(CAS DataBase Reference) |
| FDA UNII | SUC7PK4K57 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
5,6-Dimethoxyindole price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 246255 | 5,6-Dimethoxyindole 99% | 14430-23-0 | 1g | $344 | 2023-06-20 | Buy |
| TCI Chemical | D5148 | 5,6-Dimethoxyindole >98.0%(GC) | 14430-23-0 | 200mg | $58 | 2026-04-30 | Buy |
| TCI Chemical | D5148 | 5,6-Dimethoxyindole >98.0%(GC) | 14430-23-0 | 1g | $229 | 2026-04-30 | Buy |
| Apolloscientific | OR5372 | 5,6-Dimethoxy-1H-indole 98% | 14430-23-0 | 250mg | $35 | 2026-06-04 | Buy |
| Activate Scientific | AS36972 | 5,6-Dimethoxyindole 98% | 14430-23-0 | 1g | $58 | 2026-06-04 | Buy |
5,6-Dimethoxyindole Chemical Properties,Uses,Production
Chemical Properties
Beige powder
Uses
5,6-Dimethoxyindole is an indole derivative as analgesic antiinflammatory. It was used in the synthesis of N-benzyl-N-cyclopropyl-5,6-dimethoxyindole-3-glyoxalamide.
Application
5,6-Dimethoxyindole was used in the synthesis of N-benzyl-N-cyclopropyl-5,6-dimethoxyindole-3-glyoxalamide.
Reactant in synthesis of indolylhydroxyoxindoles via enantioselective Friedel-Crafts reaction
Reactant in synthesis of benzyl trimethoxyindoles
Reactant for synthesis of benzoylpiperazinyl-indolyl ethane dione derivatives as HIV-1 inhibitors
Reactant for synthesis of 1-aroylindole 3-aroylindoles combretastatin A-4 analogs as antitumor agents and tubulin polymerization inhibitors
Reactant for preparation of tryptophanol derivatives via the Grignard reaction
Synthesis Reference(s)
Journal of the American Chemical Society, 75, p. 5887, 1953 DOI: 10.1021/ja01119a030
Synthesis of 5,6-Dimethoxyindoles and 5,6-Dimethoxyoxindoles. A New Synthesis of Indoles DOI: 10.1021/ja01619a049
Synthesis
65907-71-3
14430-23-0
The general procedure for the synthesis of 5,6-dimethoxyindole from the compound (CAS: 65907-71-3) is as follows (note: use the Biotage Initiator for microwave reactions in a 2-5 mL reaction vessel): in a microwave reactor vial, an appropriate amount of o-nitrostyrene or o-nitrocinnamate (0.3 mmol) was combined with phosphine (2.4 equiv) A suspension was formed by stirring in anhydrous solvent (5 mL) and oxygen was excluded by bubbling argon into the mixture. The vessel was sealed by adding MoO2Cl2(dmf)2 (5 mol%). The reaction mixture was heated to the indicated temperature under microwave radiation and maintained for the corresponding time. Post-reaction treatments vary depending on the phosphine used: when triphenylphosphine is used, the solvent is removed under vacuum and the product is purified by column chromatography (hexane-EtOAc); when polystyrene-loaded triphenylphosphine is used, the reaction mixture is filtered and the solvent is removed under vacuum to obtain a pure indole; when 2-(diphenylphosphino)benzoic acid is used, the reaction mixture is filtered and washed with alkali if necessary. Post-reaction treatments of other phosphines were carried out with reference to the methods described in the literature [14] [15].
References
[1] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1339 - 1342
5,6-Dimethoxyindole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Kangmeng Pharmaceutical Technology Co., Ltd. | 15527333462 15527333462 | 3053535724@qq.com | China | 27 | 58 |
| Shanghai URChem Limited | +86-021-50890968，021-50891159 +86-18601776121 | danny@urchem.com | China | 639 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Lastest Price from 5,6-Dimethoxyindole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 5,6-Dimethoxyindole
14430-23-0
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2023-12-04 | 5,6-Dimethoxyindole
14430-23-0
|
1kg | 99% hplc | 1000 kg | LY Global chemicals co.,ltd . | ||
 |
2022-01-27 | 5,6-Dimethoxyindole
14430-23-0
|
1KG | 97.4% | 100 tons | Honest Joy Holdings Limited |
-
- 5,6-Dimethoxyindole
14430-23-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5,6-Dimethoxyindole
14430-23-0
- 99% hplc
- LY Global chemicals co.,ltd .
-
- 5,6-Dimethoxyindole
14430-23-0
- $0.00
- 97.4%
- Honest Joy Holdings Limited
