Boc-DL-2-aminobutyric acid
- CAS No.
- 77284-64-1
- Chemical Name:
- Boc-DL-2-aminobutyric acid
- Synonyms
- Boc-DL-2-Abu;Boc-2-aMinobutyric acid;DL-Boc-Aminobutyric acid;2-(Boc-amino)butyric Acid;Boc-DL-2-aminobutyric acid;2-(tert-butoxycarbonyl)butanoic acid;2-Aminobutanoic acid, N-BOC protected;2-[(tert-Butoxycarbonyl)amino]butanoic acid;(2R)-2-[(tert-butoxycarbonyl)amino]butanoate;Butanoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-
- CBNumber:
- CB1146853
- Molecular Formula:
- C9H17NO4
- Molecular Weight:
- 203.24
- MDL Number:
- MFCD00270358
- MOL File:
- 77284-64-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Precautionary statements | P271-P261-P280 |
|---|---|
| HazardClass | IRRITANT |
| HS Code | 2922498590 |
Boc-DL-2-aminobutyric acid price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | CDA28464 | 2-Aminobutanoic acid, N-BOC protected | 77284-64-1 | 50g | $590 | 2026-06-04 | Buy |
| Apolloscientific | OR16886 | 2-Aminobutanoic acid, N-BOC protected 97% | 77284-64-1 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR16886 | 2-Aminobutanoic acid, N-BOC protected 97% | 77284-64-1 | 25g | $94 | 2026-06-04 | Buy |
| Apolloscientific | OR16886 | 2-Aminobutanoic acid, N-BOC protected 97% | 77284-64-1 | 100g | $309 | 2026-06-04 | Buy |
| Apolloscientific | OR16886 | 2-Aminobutanoic acid, N-BOC protected 97% | 77284-64-1 | 500g | $1211 | 2026-06-04 | Buy |
Boc-DL-2-aminobutyric acid Chemical Properties, Uses, Production
Synthesis
24424-99-5
2835-81-6
77284-64-1
General procedure for the synthesis of N-Boc-DL-2-aminobutyric acid from di-tert-butyl dicarbonate and DL-2-aminobutyric acid: 10 g (96.97 mmol, 1.0 eq.) of DL-2-aminobutyric acid was dissolved in 65 mL of methanol to which 97 mL of sodium hydroxide (NaOH) solution was added. Subsequently, 25.4 g (116.37 mmol, 1.2 eq.) of di-tert-butyl dicarbonate (Boc2O) was slowly added at 0 °C. The reaction mixture was stirred at room temperature for 48 h. After completion of the reaction, it was concentrated under reduced pressure. The concentrated reaction mixture was adjusted pH to 2-3 with 1N HCl and then extracted with ethyl acetate. The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The residue was purified by column chromatography (SiO2, eluent gradient: hexane/ethyl acetate, 10:1 to hexane/ethyl acetate, 3:1) to afford 18.5 g of N-Boc-DL-2-aminobutyric acid (2-((tert-butoxycarbonyl)amino)butyric acid) as a colorless oil (91.02 mmol, 94% yield).1H NMR (300 MHz, CDCl3) δ 6.24 (s, 1H), 5.00-5.03 (d, 1H).
References
[1] Patent: US2018/105527, 2018, A1. Location in patent: Paragraph 0553-0556
[2] Catalysis Letters, 2017, vol. 147, # 4, p. 837 - 844
Boc-DL-2-aminobutyric acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Shanghai GL Peptide Ltd. | +86-21-61263310 13764994101 | fisherwang@glschina.com | China | 8059 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
