(Cyanomethyl)triphenylphosphonium chloride
- CAS No.
- 4336-70-3
- Chemical Name:
- (Cyanomethyl)triphenylphosphonium chloride
- Synonyms
- NSC 92174;Cyanomethyl triphenylphosph;cyanomethyl(triphenyl)phosphanium;(Cyanmethyl)triphenylphosphoniumchlorid;(cyanomethyl)triphenyl-phosphoniuchloride;Triphenyl(cyanomethyl)phosphonium·chloride;(Cyanomethyl)triphenylphosphonium chloride;Cyanomethyl triphenylphosphonium chloride,97%;2-(chlorotriphenyl-l5-phosphanyl)acetonitrile;(Cyanomethyl)triphenylphosphonium Chloride >
- CBNumber:
- CB1148372
- Molecular Formula:
- C20H17ClNP
- Molecular Weight:
- 337.78
- MDL Number:
- MFCD00031672
- MOL File:
- 4336-70-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 268-270 °C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| form | solid |
| color | White to Almost white |
| Water Solubility | very faint turbidity |
| Sensitive | Hygroscopic |
| BRN | 6222047 |
| InChI | 1S/C20H17NP.ClH/c21-16-17-22(18-10-4-1-5-11-18,19-12-6-2-7-13-19)20-14-8-3-9-15-20;/h1-15H,17H2;1H/q+1;/p-1 |
| InChIKey | ARPLQAMUUDIHIT-UHFFFAOYSA-M |
| SMILES | [Cl-].N#CC[P+](c1ccccc1)(c2ccccc2)c3ccccc3 |
| CAS DataBase Reference | 4336-70-3(CAS DataBase Reference) |
| FDA UNII | 3L55T65L7U |
| UNSPSC Code | 12352002 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H301-H331-H302-H312-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338-P304+P340-P501a-P264-P270-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 37/39-26 | |||||||||
| RIDADR | 3276 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TA2075000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
(Cyanomethyl)triphenylphosphonium chloride price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 464937 | (Cyanomethyl)triphenylphosphonium chloride 98% | 4336-70-3 | 25g | $142 | 2026-04-30 | Buy |
| TCI Chemical | C1739 | (Cyanomethyl)triphenylphosphonium Chloride >98.0%(HPLC)(T) | 4336-70-3 | 25g | $66 | 2026-04-30 | Buy |
| TCI Chemical | C1739 | (Cyanomethyl)triphenylphosphonium Chloride >98.0%(HPLC)(T) | 4336-70-3 | 100g | $199 | 2026-04-30 | Buy |
| ChemScene | CS-0040994 | (Cyanomethyl)triphenylphosphonium chloride ≥96% | 4336-70-3 | 10g | $12 | 2026-06-04 | Buy |
| ChemScene | CS-0040994 | (Cyanomethyl)triphenylphosphonium chloride ≥96% | 4336-70-3 | 25g | $27 | 2026-06-04 | Buy |
(Cyanomethyl)triphenylphosphonium chloride Chemical Properties, Uses, Production
Chemical Properties
off-white crystalline powder
Uses
Reactant involved in:
- Condenation reactions
- Wittig reactions
- Synthesis of phosphonium-iodonium ylides
- Preparation of α,β-unsaturated esters, amides, and nitriles
reaction suitability
reaction type: C-C Bond Formation
Synthesis
107-14-2
603-35-0
4336-70-3
The general procedure for the synthesis of cyanomethyltriphenylphosphonium chloride from chloroacetonitrile and triphenylphosphine was as follows: chloroacetonitrile (10 g, 0.132 mol) was added slowly and dropwise to a toluene solution (120 mL) of triphenylphosphine (23.5 g, 0.0895 mol), and the mixture was subsequently heated to reflux for 6 hours. After completion of the reaction, the reaction mixture was cooled to room temperature, the solid product was collected by filtration and washed with ether (2 x 20 mL). The final cyanomethyltriphenylphosphonium chloride (15 g, 49.58% yield) was obtained as a white solid. The product was characterized by NMR hydrogen spectroscopy (400 MHz, DMSO): δ 8.02-7.97 (m, 3H), 7.90-7.79 (m, 12H), 5.94 (s, 1H), 5.90 (s, 1H); Liquid Chromatography-Mass Spectrometry (electrospray ionization, m/z): [M + H]+ = 301.7.
References
[1] European Journal of Medicinal Chemistry, 2013, vol. 68, p. 132 - 138
[2] Chemistry - A European Journal, 2013, vol. 19, # 7, p. 2442 - 2449
[3] Journal of Organic Chemistry, 1980, vol. 45, # 26, p. 5316 - 5319
[4] International Journal of Chemical Kinetics, 2006, vol. 38, # 8, p. 496 - 502
[5] Patent: WO2016/105485, 2016, A2. Location in patent: Paragraph 0158
(Cyanomethyl)triphenylphosphonium chloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Creasyn Finechem(Tianjin) Co., Ltd. | 022-83946278 13820372920 | sales@creasyn.com | China | 968 | 68 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Beijing Donghualituo Techonlogy Development Co.,Ltd. | 010-88425576 | sales@dhltchem.com | China | 793 | 59 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from (Cyanomethyl)triphenylphosphonium chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | (CYANOMETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE
4336-70-3
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
|
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 |
2021-08-12 | (CYANOMETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE
4336-70-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-11-16 | (CYANOMETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE
4336-70-3
|
$20.00 | 1KG | 99% | 10000KG | Longyan Tianhua Biological Technology Co., Ltd |
-
- (CYANOMETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE
4336-70-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- (CYANOMETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE
4336-70-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- (CYANOMETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE
4336-70-3
- $20.00
- 99%
- Longyan Tianhua Biological Technology Co., Ltd
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