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6-Chlorouracil

6-Chlorouracil structure

CAS No.: 4270-27-3

Chemical Name:: 6-Chlorouracil

Synonyms: 4-CHLOROURACIL;6-chloro-1,2,3,4-tetrahydropyriMidine-2,4-dione;NSC 43265;orouraciL;NSC 210419;Chlorouracil;AURORA KA-4918;6-CHLOROURACIL;6-Chlorouracil>6-Chlorouracil 98%

CBNumber:: CB1157303

Molecular Formula:: C4H3ClN2O2

Molecular Weight:: 146.53

MDL Number:: MFCD00014595

MOL File:: 4270-27-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:12:47

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6-Chlorouracil Properties

Melting point	290-295°C
Boiling point	300°C
Density	1.61±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in Ammonium Hydroxide
pka	6.24±0.10(Predicted)
form	Solid
color	White
Water Solubility	4.885g/L(25 ºC)
BRN	120492
InChI	InChI=1S/C4H3ClN2O2/c5-2-1-3(8)7-4(9)6-2/h1H,(H2,6,7,8,9)
InChIKey	PKUFNWPSFCOSLU-UHFFFAOYSA-N
SMILES	C1(=O)NC(Cl)=CC(=O)N1
CAS DataBase Reference	4270-27-3(CAS DataBase Reference)
NIST Chemistry Reference	6-Chlorouracil(4270-27-3)
UNSPSC Code	41106305
NACRES	NA.51

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HazardClass

IRRITANT

HS Code

29335990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

6-Chlorouracil price More Price(69)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S783242	6-CHLOROURACIL Aldrich^CPR	4270-27-3	1 unit	$197	2026-04-30	Buy
Sigma-Aldrich	C9525	4-Chlorouracil ≥99%	4270-27-3	10g	$661	2026-04-30	Buy
Sigma-Aldrich	S783242	6-CHLOROURACIL Aldrich	4270-27-3	50mg	$179	2024-03-01	Buy
TCI Chemical	C2093	6-Chlorouracil >98.0%(T)	4270-27-3	5g	$21	2026-04-30	Buy
TCI Chemical	C2093	6-Chlorouracil >98.0%(T)	4270-27-3	25g	$81	2026-04-30	Buy

Product number	Packaging	Price	Buy
S783242	1 unit	$197	Buy
C9525	10g	$661	Buy
S783242	50mg	$179	Buy
C2093	5g	$21	Buy
C2093	25g	$81	Buy

6-Chlorouracil Chemical Properties,Uses,Production

Chemical Properties

White to off-white powder

Uses

6-Chlorouracil acts as an inhibitor of yeast alcohol dehydrogenase (ADH-H). 6-Chlorouracil is a potential inhibitor of DNA repair glycosylases.

Uses

Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity. Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines.

Synthesis

3764-01-0

4270-27-3

General procedure for the synthesis of 6-chloropyrimidine-2,4(1H,3H)-dione from 2,4,6-trichloropyrimidine: 2,4,6-trichloropyrimidine (10.21 g, 0.56 mol) was dissolved in an aqueous solution (100 mL) containing NaOH (8.9 g, 0.22 mol), which was stirred under refluxing conditions for 1 hour. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 2-3 with concentrated hydrochloric acid. the mixture was placed in a refrigerator overnight to promote crystallization. Subsequently, the precipitate was collected by filtration, washed with cold water and dried under vacuum in the presence of phosphorus pentoxide. 6.43 g (0.54 mol, 97% yield) of 6-chlorouracil was finally obtained as a white crystalline solid. The spectral data of the product were in agreement with those reported in the literature [28] and [40]. Melting point > 280°C. 1H NMR (300 MHz, DMSO-d6) δ (ppm): 12.00 (broad peak, 1H, NH), 11.09 (broad peak, 1H, NH), 5.66 (single peak, 1H, CH). IR (KBr, ν cm-1): 3095 (N-H stretching vibration), 1729,1709,1652 (C=O stretching vibration), 1616 (C=C stretching vibration), 1380 (C-N stretching vibration), 841 (N-H out-of-plane bending vibration), 790 (C-Cl stretching vibration).

References

[1] European Journal of Organic Chemistry, 2008, # 32, p. 5401 - 5406
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 16, p. 6352 - 6370
[3] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 159 - 174
[4] Organic Letters, 2018, vol. 20, # 2, p. 473 - 476
[5] Heterocycles, 1990, vol. 31, # 9, p. 1641 - 1646

6-Chlorouracil synthesis

Synthesis of 6-Chlorouracil from 2,4,6-Trichloropyrimidine

6-Chlorouracil Preparation Products And Raw materials

Raw materials

6-CHLORO-2,4-DIMETHOXYPYRIMIDINE Sodium hydroxide Hydrochloric acid Barbituric acid 2,4,6-Trichloropyrimidine

Preparation Products

6-Chlorouracil 6-Iodouracil 2-[(6-CHLORO-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)METHYL]BENZONITRILE 5,6-Dichloropyrimidine-2,4-diol 6-morpholinopyrimidine-2,4(1H,3H)-dione

2,4(1H,3H)-Pyrimidinedione, 6-[(3-methylbutyl)amino]- 6-METHYLAMINOURACIL 6-(N-Methyl-3,4-xylidino)uracil

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6-Chlorouracil Suppliers

Global( 420)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.	021-69106960 13701823997	13701823733@163.com	China	4634	60
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56

Supplier	Advantage
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.	60
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56

View Lastest Price from 6-Chlorouracil manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-24	6-chlorouracil 4270-27-3		1Kg	99.9%	200tons	airuikechemical co., ltd.
2023-03-14	6-Chlorouracil 4270-27-3		1kg	98%Min	1000kg	LY Global chemicals co.,ltd .
2021-12-03	6-Chlorouracil 4270-27-3	$10.00	1Kg/Bag	99%	20 Tons	Hebei Zhanyao Biotechnology Co. Ltd

6-chlorouracil
4270-27-3
99.9%
airuikechemical co., ltd.

6-Chlorouracil
4270-27-3
98%Min
LY Global chemicals co.,ltd .

6-Chlorouracil
4270-27-3
$10.00
99%
Hebei Zhanyao Biotechnology Co. Ltd

6-Chlorouracil Spectrum

6-Chlorouracil(4270-27-3)MS 6-Chlorouracil(4270-27-3)¹HNMR 6-Chlorouracil(4270-27-3)¹³CNMR 6-Chlorouracil(4270-27-3)IR1 6-Chlorouracil(4270-27-3)IR2

4270-27-3(6-Chlorouracil)Related Search:

Uracil 1,3-Dimethyl-4-chlorouracil,1,3-DIMETHYL-6-CHLOROURACIL 6-CHLORO-2,4-DIMETHOXYPYRIMIDINE Difluorochloromethane 5-CHLOROURACIL,5-CHLORO-2,4-DIHYDROXYPYRIMIDINE,5-CHLOROURACIL CRYSTALLINE,5-Chlorouracil,98%,5-CHLOROURACIL

5-Chlorouridine 6-methyl-5-chlorouracil 4-AMINOPYRAZOLO[3,4-D]PYRIMIDINE 6-Chloro-3-methyluracil 6-Chloro-5-Nitropyrimidine-2,4-Diol

3,5-Diethyl-1-allyl-6-chlorouracil,1-Allyl-3,5-diethyl-6-chlorouracil 5-ETHYL-6-CHLOROURACIL 1,3-Dimethyl-5-chlorouracil 1-(3-Fluoro-2,3-dideoxy-β-D-erythro-pentofuranosyl)-5-chlorouracil 5-Chlorouracil-15N2,13C

6-Chlorouracil 6-CHLORO-3-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)-2,4(1H,3H)-PYRIMIDINEDIONE 6-CHLORO-1-ETHYL-3-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE

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6-chloro-1H-pyrimidine-2,4-dione Chlorouracil 6-Chlorouracil ,99% 2,4(1H,3H)-Pyrimidinedione, 6-chloro- (9CI) 6-Chlorouracil,98+% 4-Chloro-2,6-dihydroxypyrimidine, 6-Chloro-2,4-dihydroxypyrimidine, 6-Chlorouracil Tragliptin Starter 1 Impurity 4 6-chloro-1,2,3,4-tetrahydropyriMidine-2,4-dione AURORA KA-4918 6 - chlorine uracil 6-Chloro-2,4-pyriMidinediol NSC 210419 NSC 43265 6-Chloropyrimidine-2,4(1H,3H)-dione, 6-Chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidine 6-CHLOROURACIL 6-CHLORO-2,4-DIHYDROXYPYRIMIDINE 6-CHLORO-2,4(1H,3H)-PYRIMIDINEDIONE 4-CHLORO-2,6-DIHYDROXYPYRIMIDINE TIMTEC-BB SBB004104 SPECS AB-323/25048125 2,4(1H,3H)-Pyrimidinedione, 6-chloro- 2,4-Pyrimidinediol,6-chloro- 6-Chloro-2,4-dihydroxypyrimidine~4-Chlorouracil orouraciL Trelagliptin Impurity 50 6-Chlorouracil> 6- Chloro pyrimidine-2,4(1H,3H)-dione (6-Chlorouracil) 6-Chloropyrimidine-2,4(1H,3H)-dione? (Sitagliptin Impurity) 6-Chloro uracil & 4-Chloro uracil Alogliptin Benzoate Impurity1639 TIANFU-CHEM 6-Chlorouracil 6-Chlorouracil (or) 6-Chloropyrimidine-2,4(1H,3H)-dione 6-Chlorouracil 98% 4-CHLOROURACIL 4270-27-3 4720-27-3 4720-27-3 C4H3CIN2O2 C4H3N2O2Cl Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs BioChemical Biochemicals and Reagents PYRIMIDINE Pyridines, Pyrimidines, Purines and Pteredines Biochemistry Nucleobases and their analogs Nucleosides, Nucleotides & Related Reagents bc0001