Dodecyl gallate
- CAS No.
- 1166-52-5
- Chemical Name:
- Dodecyl gallate
- Synonyms
- LAURYL GALLATE;E312;96-97℃;3mg/kg;progallinla;Progallin LA;nipagallinla;dodecyl3,4,5-;Nipagallin LA;auryl gallate
- CBNumber:
- CB1159943
- Molecular Formula:
- C19H30O5
- Molecular Weight:
- 338.44
- MDL Number:
- MFCD00002195
- MOL File:
- 1166-52-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 94-97 °C (lit.) |
|---|---|
| Boiling point | 394.57°C (rough estimate) |
| Density | 1.0677 (rough estimate) |
| refractive index | 1.6120 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | Very slightly soluble or practically insoluble in water, freely soluble in ethanol (96 per cent), slightly soluble in methylene chloride. |
| pka | 7.93±0.25(Predicted) |
| form | Solid |
| color | White to Almost white |
| Odor | at 100.00%. odorless |
| Water Solubility | practically insoluble |
| Sensitive | Air Sensitive |
| BRN | 2701981 |
| Major Application |
cleaning products cosmetics food and beverages personal care |
| Cosmetics Ingredients Functions | ANTIOXIDANT |
| InChI | 1S/C19H30O5/c1-2-3-4-5-6-7-8-9-10-11-12-24-19(23)15-13-16(20)18(22)17(21)14-15/h13-14,20-22H,2-12H2,1H3 |
| InChIKey | RPWFJAMTCNSJKK-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCOC(=O)c1cc(O)c(O)c(O)c1 |
| LogP | 6.365 (est) |
| CAS DataBase Reference | 1166-52-5(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | DODECYL GALLATE |
| EWG's Food Scores | 1-3 |
| FDA UNII | 45612DY463 |
| NIST Chemistry Reference | Gallic acid, n-dodecyl ester(1166-52-5) |
| EPA Substance Registry System | Benzoic acid, 3,4,5-trihydroxy-, dodecyl ester (1166-52-5) |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317 | |||||||||
| Precautionary statements | P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 43 | |||||||||
| Safety Statements | 24-37 | |||||||||
| RIDADR | 3335 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | DH9100000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29182950 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| Hazard Classifications | Skin Sens. 1 | |||||||||
| Toxicity | LD50 orally in Rabbit: 5000 mg/kg | |||||||||
| NFPA 704 |
|
Dodecyl gallate price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000365 | Dodecyl gallate European Pharmacopoeia (EP) Reference Standard | 1166-52-5 | 30 mg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR3510 | Lauryl gallate certified reference material, pharmaceutical secondary standard | 1166-52-5 | 500MG | $318 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.20598 | Dodecyl 3,4,5-trihydroxybenzoate for synthesis | 1166-52-5 | 100G | $101 | 2026-04-30 | Buy |
| Sigma-Aldrich | 48660 | Lauryl gallate antioxidant, ≥99.0% (HPLC) | 1166-52-5 | 50g | $114 | 2026-04-30 | Buy |
| Sigma-Aldrich | 48660 | Lauryl gallate antioxidant, ≥99.0% (HPLC) | 1166-52-5 | 250g | $499 | 2026-04-30 | Buy |
Dodecyl gallate Chemical Properties,Uses,Production
Description
This gallate ester (E 310) is an antioxidant added to foods and cosmetics to prevent oxidation of unsaturated fatty acids. Cases have been reported in workers in the food industry, gallate being contained in margarine. It is also present in washing powder.
Chemical Properties
white to cream powder
Uses
Dodecyl Gallate is an antioxidant used in cream cheese, instant mashed potatoes, margarine, fats, and oils.
Uses
Dodecyl 3,4,5-Trihydroxybenzoate is used in method for stabilizing the pH of an aqueous compound comprising drug.
Uses
Dodecyl gallate is an antioxidant in cosmetic and pharmaceutical creams and emulsions, various fats, oils, waxes, and foods, such as margarine.
Definition
ChEBI: Dodecyl gallate is a gallate ester.
General Description
Lauryl gallate is a major monomer flavanol found in green tea and shows antioxidant activity in polymers.
Biological Activity
Dodecyl gallate exhibits both potent chain-breaking and preventive antioxidant activity. The pyrogallol moiety is responsible for both activities. Dodecyl (lauryl) gallate prevents generation of superoxide radicals by xanthine oxidase, and this activity comes from its ability to inhibit the enzyme[1].
Contact allergens
This gallic acid ester (E 310) is an antioxidant added to food and cosmetics to prevent oxidation of unsaturated fatty acids. Cases were reported in workers of the food industry, gallate being contained in margarine, and from washing powder.
Safety Profile
Poison by ingestion and inhalation. Moderately toxic by skin contact. A severe eye irritant. Questionable carcinogen with experimental tumorigenic data. A pesticide. When heated to decomposition it emits very toxic fumes of NOx.
Carcinogenicity
In a 2-year feeding study, with the administration of up to 5 mg/kg of feed to rats, no increase in tumor incidence was noted . In female mice, a dermal injection of dodecyl gallate (100 nmol in 0.2mL acetone) inhibits the formation of skin carcinomas and papillomas induced by the tumor promoter phorbol myristate and the initiator 7,12-dimethylbenz[a]anthracene .
References
[1] Kubo, I., Masuoka, N., Xiao, P., Haraguchi, H. (2002). Antioxidant Activity of Dodecyl Gallate. Journal of Agricultural and Food Chemistry, 50 12, 3533–3539. https://doi.org/10.1021/jf011250h
Dodecyl gallate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Optimal New Materials Technology Co., Ltd. | 180-86404407 17340521416 | 1757224788@qq.com | China | 1011 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Lastest Price from Dodecyl gallate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Dodecyl gallate
1166-52-5
|
$5.00 | 1kg | ≥99% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-09-11 | Dodecyl Gallate
1166-52-5
|
1kg | 99.5 | 20MT | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | Dodecyl gallate
1166-52-5
|
$1.30-32.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd |
-
- Dodecyl gallate
1166-52-5
- $5.00
- ≥99%
- Jinan Finer Chemical Co., Ltd
-
- Dodecyl Gallate
1166-52-5
- 99.5
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Dodecyl gallate
1166-52-5
- $1.30-32.00
- 99%
- Henan Fengda Chemical Co., Ltd
