| Company Name: |
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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| Tel: |
400-6206333 13167063860 |
| Email: |
anhua.mao@aladdin-e.com |
| Products Intro: |
Product Name:PGF1α (Prostaglandin F1α)
CAS:745-62-0
Purity:Moligand?, ≥98% Package:1mg/RMB 999.90;5mg/RMB 4199.90
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:PGF1alpha
CAS:745-62-0
Purity:Prostaglandin F1alpha, powder Package:1MG Remarks:900105P-1MG
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| | PROSTAGLANDIN F1ALPHA Basic information |
| Product Name: | PROSTAGLANDIN F1ALPHA | | Synonyms: | prostaglandinf1;protaglandinf1;PROSTAGLANDIN F1A;syntheticwhitecrystallinesolid;(9α,11α,13e,15s)-9,11,15-trihydroxyprost-13-en-1-oic acid;(9a,11a,13E,15S)- 9,11,15-trihydroxy-Prost-13-en-1-oic acid;PGF1α, (9α,11α,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid;(13E,15S)-9α,11α,15-Trihydroxyprost-13-en-1-oic acid | | CAS: | 745-62-0 | | MF: | C20H36O5 | | MW: | 356.5 | | EINECS: | 234-237-8 | | Product Categories: | | | Mol File: | 745-62-0.mol |  |
| | PROSTAGLANDIN F1ALPHA Chemical Properties |
| Melting point | 102.5°C | | Boiling point | 409.31°C (rough estimate) | | alpha | +24°(D/24℃)(c=0.87,THF) | | density | 1.0321 (rough estimate) | | refractive index | 1.6120 (estimate) | | storage temp. | -20°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 2 mg/ml | | form | A crystalline solid | | pka | 4.78±0.10(Predicted) | | color | White to off-white | | BRN | 2704846 | | InChI | 1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1 | | InChIKey | DZUXGQBLFALXCR-CDIPTNKSSA-N | | SMILES | O[C@@H]1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1 |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | GY4569700 | | F | 8-10 | | Storage Class | 11 - Combustible Solids |
| | PROSTAGLANDIN F1ALPHA Usage And Synthesis |
| Description | Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α (Item Nos. 16010 | 10007221) have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10−11 M. PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. | | Description | Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α (Item Nos. 16010 | 10007221) have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10−11 M. PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro.
PGF1α MaxSpec® standard is a quantitative grade standard of PGF1α that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This PGF1α MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality. | | Uses | PGF1alpha (Prostaglandin F1alpha) is a smooth muscle relaxant and a stable metabolite of prostacyclin (PGI2). | | Uses | Prostaglandin F1α (PGF1α) is the putative metabolite of dihomo-γ-linolenic acid (DGLA) via the cyclooxygenase (COX) pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 1011 M. PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α. It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro. | | Definition | ChEBI: Prostaglandin F1alpha is a prostaglandins Falpha. It has a role as a human metabolite. | | General Description | Prostaglandins (PGs) contain prostanoic acid. They are divided as PGA, PGB, PGC, PGD, PGE and PGF groups. They all contain a five-member ring structure differing in their functions. PGF is known to be more soluble in phosphate buffer. PGF1α is a serum eicosanoid. | | Biochem/physiol Actions | PGs mediate vasodilation and vasoconstriction. | | References | [1] ANIL K. BALAPURE . Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptor[J]. Biochemical pharmacology, 1989, 38 14: Pages 2375-2381. DOI: 10.1016/0006-2952(89)90478-4
[2] S M KARIM S R K P G Adaikan. Prostaglandins and human respiratory tract smooth muscle: structure activity relationship.[J]. Advances in prostaglandin and thromboxane research, 1980, 7: 969-980.
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| | PROSTAGLANDIN F1ALPHA Preparation Products And Raw materials |
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