Cyclopenthiazide
- CAS No.
- 742-20-1
- Chemical Name:
- Cyclopenthiazide
- Synonyms
- su8341;salimid;salimed;navidrix;NAVIDREX;Navidreks;NSC 107679;Salurilo-C;Ciba 8341-Su;Ultra-Minzil
- CBNumber:
- CB1295254
- Molecular Formula:
- C13H18ClN3O4S2
- Molecular Weight:
- 379.88
- MDL Number:
- MFCD00865825
- MOL File:
- 742-20-1.mol
- MSDS File:
- SDS
| Melting point | 230° |
|---|---|
| Boiling point | 605.6±65.0 °C(Predicted) |
| Density | 1.3650 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | Refrigerator |
| solubility | Acetonitrile (Slightly), DMSO (Slightly), Methanol (Sparingly) |
| form | Solid |
| pka | 9.00±0.40(Predicted) |
| color | White to Off-White |
| Water Solubility | 50mg/L(room temperature) |
| Major Application |
pharmaceutical pharmaceutical small molecule |
| InChI | 1S/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19) |
| InChIKey | BKYKPTRYDKTTJY-UHFFFAOYSA-N |
| SMILES | [S]1(=O)(=O)NC(Nc3c1cc(c(c3)Cl)[S](=O)(=O)N)CC2CCCC2 |
| CAS DataBase Reference | 742-20-1(CAS DataBase Reference) |
| FDA UNII | VX4S2N85F5 |
| ATC code | C03AA07 |
| EPA Substance Registry System | 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide (742-20-1) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335-H373 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | WGK 1 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
| Toxicity | LD50 in rats, mice (mg/kg): 141.8 ±24, 232.4 ±25 i.v. (Barrett) |
Cyclopenthiazide price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3958 | Cyclopenthiazide | 742-20-1 | 200MG | $50 | 2026-04-30 | Buy |
| TCI Chemical | C3958 | Cyclopenthiazide | 742-20-1 | 1G | $175 | 2026-04-30 | Buy |
| TRC | TRC-C988420-25MG | Cyclopenthiazide >95%(HPLC) | 742-20-1 | 25mg | $275 | 2026-06-03 | Buy |
| TRC | TRC-C988420-250MG | Cyclopenthiazide >95%(HPLC) | 742-20-1 | 250mg | $2033 | 2026-06-03 | Buy |
| ChemScene | CS-0031283 | Cyclopenthiazide 98.40% | 742-20-1 | 100mg | $54 | 2026-06-04 | Buy |
Cyclopenthiazide Chemical Properties, Uses, Production
Uses
Cyclopenthiazide is a thiazide diuretic. Cyclopenthiazide is used in the treatment of oedema caused by conditions such as kidney disease, liver cirrhosis and pre-menstrual syndrome as well as in the treatment of hypertension.
Uses
Antihypertensive;Sodium Chloride Symporter Inhibitor
Definition
ChEBI: 6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide is a benzothiadiazine.
World Health Organization (WHO)
Cyclopenthiazide, a thiazide diuretic, was introduced in 1968. It continues to be used mainly in combination drugs.
Clinical Use
Thiazide diuretic:
Hypertension
Heart failure
Oedema
Drug interactions
Potentially hazardous interactions with other drugs
Analgesics: increased risk of nephrotoxicity with
NSAIDs; antagonism of diuretic effect. Anti-arrhythmics: hypokalaemia leads to increased
cardiac toxicity; effects of lidocaine and mexiletine
antagonised.
Antibacterials: avoid administration with
lymecycline.
Antidepressants: increased risk of hypokalaemia
with reboxetine; enhanced hypotensive effect with
MAOIs; increased risk of postural hypotension with
tricyclics.
Antiepileptics: increased risk of hyponatraemia with
carbamazepine.
Antifungals: increased risk of hypokalaemia with
amphotericin.
Antihypertensives: enhanced hypotensive effect;
increased risk of first dose hypotension with postsynaptic alpha-blockers like prazosin; hypokalaemia
increases risk of ventricular arrhythmias with sotalol.
Antipsychotics: hypokalaemia increases risk
of ventricular arrhythmias with amisulpride;
enhanced hypotensive effect with phenothiazines;
hypokalaemia increases risk of ventricular
arrhythmias with pimozide - avoid.
Atomoxetine: hypokalaemia increases risk of
ventricular arrhythmias.
Cardiac glycosides: increased toxicity if hypokalaemia
occurs.
Ciclosporin: increased risk of nephrotoxicity and
possibly hypomagnesaemia.
Cytotoxics: increased risk of ventricular arrhythmias
due to hypokalaemia with arsenic trioxide; increased
risk of nephrotoxicity and ototoxicity with platinum
compounds.
Lithium: excretion reduced, increased toxicity
Metabolism
Cyclopenthiazide appears to be entirely excreted unchanged in the urine.
Cyclopenthiazide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13323 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9170 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
View Latest Price from Cyclopenthiazide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-02 | Cyclopenthiazide
742-20-1
|
$1.00 | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2023-09-11 | Cyclopenthiazide
742-20-1
|
$80.00 | 1kg | 99% | 10000tons | Anhui Ruihan Technology Co., Ltd | |
 |
2021-08-12 | Cyclopenthiazide
742-20-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Cyclopenthiazide
742-20-1
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Cyclopenthiazide
742-20-1
- $80.00
- 99%
- Anhui Ruihan Technology Co., Ltd
-
- Cyclopenthiazide
742-20-1
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
