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Fmoc-L-tert-leucine

Fmoc-L-tert-leucine Structure
Fmoc-L-tert-leucine structure
CAS No.
132684-60-7
Chemical Name:
Fmoc-L-tert-leucine
Synonyms
FMOC-TLE-OH;Fmoc-Tle;(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3,3-diMethylbutanoic acid;FMOC-L-TLE-OH;FMOC-TBU-GLY-OH;Fmoc-L-α-tert-butylglycine;FMOC-TBU-GLYCINE;FMOC-L-T-LEUCINE;RARECHEM EM WB 0083;FMOC-L-TERT-LEUCINE
CBNumber:
CB1386464
Molecular Formula:
C21H23NO4
Molecular Weight:
353.41
MDL Number:
MFCD00065649
MOL File:
132684-60-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:34:11
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Fmoc-L-tert-leucine Properties

Melting point 124-127 °C
Boiling point 554.1±33.0 °C(Predicted)
Density 1.209±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility ≥ 35.3mg/mL in DMSO, ≥ 49.6 mg/mL in EtOH
form powder to crystal
pka 3.92±0.10(Predicted)
color White to Light yellow
BRN 6662856
Major Application peptide synthesis
InChI 1S/C21H23NO4/c1-21(2,3)18(19(23)24)22-20(25)26-12-17-15-10-6-4-8-13(15)14-9-5-7-11-16(14)17/h4-11,17-18H,12H2,1-3H3,(H,22,25)(H,23,24)/t18-/m1/s1
InChIKey VZOHGJIGTNUNNC-GOSISDBHSA-N
SMILES CC(C)(C)[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
CAS DataBase Reference 132684-60-7(CAS DataBase Reference)
UNSPSC Code 12352209
NACRES NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  22-24/25
WGK Germany  3
HazardClass  IRRITANT
HS Code  29242990
Storage Class 11 - Combustible Solids

Fmoc-L-tert-leucine price More Price(88)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.52027 Fmoc-α-t-butylglycine Novabiochem? 132684-60-7 1g $193 2026-04-30 Buy
Sigma-Aldrich 8.52027 Fmoc-α-t-butylglycine Novabiochem? 132684-60-7 5G $760 2026-04-30 Buy
Sigma-Aldrich 47524 Fmoc-tBu-Gly-OH ≥98.0% 132684-60-7 1g $326 2026-04-30 Buy
TCI Chemical F1251 N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tert-leucine 132684-60-7 5G $53 2026-04-30 Buy
TCI Chemical F1251 N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tert-leucine 132684-60-7 25G $212 2026-04-30 Buy
Product number Packaging Price Buy
8.52027 1g $193 Buy
8.52027 5G $760 Buy
47524 1g $326 Buy
F1251 5G $53 Buy
F1251 25G $212 Buy

Fmoc-L-tert-leucine Chemical Properties,Uses,Production

Chemical Properties

solid

Uses

Fmoc-Tle-OH is a versatile reactant used in the discovery of potent antagonists of antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) for treatment of cancer. It is also used as reactant in the preparation of phosphino dipeptide derivatices as ligand in copper-phosphine catalyst for asymmetric conjugate addition of alkylzinc reagents to unsaturated ketones.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

L-tert-Leucine

20859-02-3

9-Fluorenylmethyl chloroformate

28920-43-6

Fmoc-L-tert-leucine

132684-60-7

General procedure for the synthesis of Fmoc-L-tert-leucine from L-tert-leucine and 9-fluorenylmethyl chloroformate: a 500 mL reaction flask was taken and to it was added L-tert-leucine (5.1 g, 38.6 mmol), dioxane (40 mL), and 10% sodium carbonate solution (100 mL). The reaction flask was placed in an ice bath and a dioxane solution (100 mL) of methyl chloroformate-9-fluorenyl (10.0 g, 38.6 mmol) was slowly added through a dropping funnel under mechanical stirring. After dropwise addition, the solution was gradually returned to room temperature and stirring was continued overnight. After completion of the reaction, 100 mL of water was added and extracted three times with 50 mL of ether, retaining the aqueous phase. The aqueous phase was cooled in an ice bath and the pH was adjusted slowly to 1 by adding 1 M dilute hydrochloric acid. subsequently, the aqueous solution was extracted three times with 50 mL of ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to dryness to give the intermediate Fmoc-L-tert-leucine (14.3 g, 96% yield).

References

[1] Patent: CN106588987, 2017, A. Location in patent: Paragraph 0195; 0196; 0197
[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 45, p. 11846 - 11851
[3] Angew. Chem., 2013, vol. 125, # 45, p. 12062 - 12067,6
[4] Chemistry - A European Journal, 2014, vol. 20, # 21, p. 6526 - 6531
[5] Patent: WO2018/145021, 2018, A1. Location in patent: Page/Page column 134

Fmoc-L-tert-leucine Preparation Products And Raw materials

Raw materials

L-tert-Leucine 9-Fluorenylmethyl chloroformate Sodium carbonate 1,4-Dioxane

Preparation Products

Fmoc-L-tert-leucine Suppliers

Global( 199)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Lavem Chine Pharm Company 028-62070218 18190869852 sales@lavemc.com China 214 67
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
GL Biochem (Shanghai) Ltd 64
Jia Xing Isenchem Co.,Ltd 66
Accela ChemBio Co.,Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60
Shandong Xiya Chemical Co., Ltd 57
Lavem Chine Pharm Company 67

View Lastest Price from Fmoc-L-tert-leucine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fmoc-L-Tle-OH pictures 2026-09-11 Fmoc-L-Tle-OH
132684-60-7
 1kg 98% 1T Sichuan HongRi Pharma-Tech Co.,Ltd
Fmoc-L-tert-leucine pictures 2020-01-05 Fmoc-L-tert-leucine
132684-60-7
 $9.80 1g ≥99% 100kg Career Henan Chemical Co

Fmoc-L-tert-leucine Spectrum

Fmoc-L-tert-leucine(132684-60-7)1HNMRFmoc-L-tert-leucine(132684-60-7)1HNMR

132684-60-7(Fmoc-L-tert-leucine)Related Search:

N-CARBOBENZOXY-DL-LEUCINE Nalpha-Fmoc-Ndelta-trityl-L-glutamine tert-Butyl peroxyacetate Fmoc-Phe-OH 9-Fluorenylmethyl chloroformate
METHOXYCARBONYLSULFENYL CHLORIDE Fmoc-Lys(Boc)-OH L-Fmoc-Aspartic acid alpha-tert-butyl ester FMOC-L-Valine 6-Aminocaproic acid
tert-Butyl acetate Fmoc-Asp(OtBu)-OH Fmoc-OSu DL-Leucine L-tert-Leucine
Glycine tert-Butanol FMOC-N-Methyl-L-alanine

1of4

(S)-N-FMOC-2-AMINO-3,3-DIMETHYL BUTANOIC ACID RARECHEM EM WB 0083 N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-TERT-BUTYL-GLYCINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-T-LEUCINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-(S)-2-AMINO-3,3-DIMETHYL-BUTYRIC ACID FMOC-L-T-BUTYLGLYCINE FMOC-L-TERT-LEUCINE FMOC-TBU-GLYCINE FMOC-TBU-GLY-OH FMOC-ALPHA-T-BUTYL-GLY-OH FMOC-ALPHA-T-BUTYLGLYCINE FMOC-L-ALPHA-T-BUTYLGLYCINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-ALPHA-T-BUTYLGLYCINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-TERT-LEUCINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-T-LEUCINE N-ALPHA-FMOC-L-T-BUTYLGLYCINE N-ALPHA-FMOC-L-T-LEUCINE N-ALPHA-FMOC-L-ALPHA-T-BUTYL-GLYCINE N-ALPHA-T-FMOC-L-ALPHA-T-BUTYL-GLYCINE N-ALPHA-T-FMOC-L-T-LEUCINE N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-t-leucine, N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-t-butyl-glycine (S)-2-(((9H-fluoren-9-yl)methoxy)carbonyl)-3,3-dim (S)-N-Fmoc-2-amino-3,3-dimethyl-butyric acid N-9-Fluorenylmethoxycarbonyl-L-tert-leucine Fmoc-L-tert-leucine, Fmoc-Tle-OH FMoc-Tle-OH (FMoc-tertleucine) FMOC-L-T-LEUCINE Fmoc-L-α-tert-butylglycine≥ 99% (HPLC) (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3-dimethylbutanoic acid Fmoc-tBu-Gly-OH, ≥98.0% Fmoc-L-α-tert-butyl-Gly-OH Fmoc-α-t-butylglycine Novabiochem (9H-Fluoren-9-yl)MethOxy]Carbonyl Tle-OH L-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-methyl- N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-tert-leucine (S)-2-(Fmoc-amino)-3,3-dimethylbutyric Acid N-Fmoc-L-tert-leucine Fmoc-L-tert-leucine USP/EP/BP Fmoc-L-alpha-t-butylglycine - 1 g N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-L-valine (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3,3-diMethylbutanoic acid FMOC-L-TLE-OH FMOC-TLE-OH Fmoc-L-α-tert-butylglycine Fmoc-Tle Fmoc-α-t-butylglycine 132684-60-7 145099-56-3 Leucine Derivatives Peptide Synthesis Unnatural Amino Acid Derivatives Specialty Synthesis Amino Acids & Deriv. CHIRAL CHEMICALS Peptide API intermediates Amino Acids