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(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE

(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE structure

CAS No.: 128811-48-3

Chemical Name:: (R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE

Synonyms: METHYL (R)-N-(TERT-BUTOXYCARBONYL)PYROGLUTAMATE;1-tert-butyl 2-methyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate;utamic Acid MethyL;1-Boc-5-oxo-D-proline Methyl ester;Boc-L-pyroglutamic acid methyl ester;Boc-D-Pyroglutamic acid methyl ester;(R)-N-(tert-butoxycarbonyl)pyroglutaMate;(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE;(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE USP/EP/BP;-1-tert-Butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate

CBNumber:: CB1433447

Molecular Formula:: C11H17NO5

Molecular Weight:: 243.26

MDL Number:: MFCD07783728

MOL File:: 128811-48-3.mol

MSDS File:: SDS

Last updated:2026-05-27 23:35:05

Product description	Number	Pack Size	Price
1-tert-Butyl 2-methyl (2R)-(+)-5-oxopyrrolidine-1,2-dicarboxylate >98%	OR41145	5g	$21
1-tert-Butyl 2-methyl (2R)-(+)-5-oxopyrrolidine-1,2-dicarboxylate >98%	OR41145	25g	$22
1-tert-Butyl 2-methyl (2R)-(+)-5-oxopyrrolidine-1,2-dicarboxylate >98%	OR41145	100g	$85
1-tert-Butyl 2-methyl (2R)-(+)-5-oxopyrrolidine-1,2-dicarboxylate >98%	OR41145	500g	$411
1-tert-Butyl 2-methyl (2R)-(+)-5-oxopyrrolidine-1,2-dicarboxylate >98%	OR41145	2.5kg	$2008
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(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE Properties

Melting point	68-69℃
Boiling point	361.6±35.0 °C(Predicted)
Density	1.209
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	-4.28±0.40(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C11H17NO5/c1-11(2,3)17-10(15)12-7(9(14)16-4)5-6-8(12)13/h7H,5-6H2,1-4H3/t7-/m1/s1
InChIKey	FNTAOUUEQHKLIU-SSDOTTSWSA-N
SMILES	N1(C(OC(C)(C)C)=O)C(=O)CC[C@@H]1C(OC)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
HS Code	2933790090

(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR41145	1-tert-Butyl 2-methyl (2R)-(+)-5-oxopyrrolidine-1,2-dicarboxylate >98%	128811-48-3	5g	$21	2026-06-04	Buy
Apolloscientific	OR41145	1-tert-Butyl 2-methyl (2R)-(+)-5-oxopyrrolidine-1,2-dicarboxylate >98%	128811-48-3	25g	$22	2026-06-04	Buy
Apolloscientific	OR41145	1-tert-Butyl 2-methyl (2R)-(+)-5-oxopyrrolidine-1,2-dicarboxylate >98%	128811-48-3	100g	$85	2026-06-04	Buy
Apolloscientific	OR41145	1-tert-Butyl 2-methyl (2R)-(+)-5-oxopyrrolidine-1,2-dicarboxylate >98%	128811-48-3	500g	$411	2026-06-04	Buy
Apolloscientific	OR41145	1-tert-Butyl 2-methyl (2R)-(+)-5-oxopyrrolidine-1,2-dicarboxylate >98%	128811-48-3	2.5kg	$2008	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR41145	5g	$21	Buy
OR41145	25g	$22	Buy
OR41145	100g	$85	Buy
OR41145	500g	$411	Buy
OR41145	2.5kg	$2008	Buy

(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE Chemical Properties,Uses,Production

Uses

(R)-1-tert-Butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate is a useful intermediate used in the synthesis of (-)-Kaitocephalin; a non-selective ionotropic glutamate receptor antagonist.

Synthesis

24424-99-5

68766-96-1

144978-12-1

General procedure for the synthesis of BOC-L-pyroglutamic acid ethyl ester from di-tert-butyl dicarbonate and D-pyroglutamic acid ethyl ester: D-pyroglutamic acid ethyl ester (5.1 g, 32.6 mmol) was dissolved in dichloromethane (70 ml), and triethylamine (4.55 ml, 32.6 mmol), di-tert-butyl dicarbonate (14.2 g, 65.2 mmol) and 4- ( dimethylamino)pyridine (3.98 g, 32.6 mmol). The reaction mixture was stirred at room temperature for 1.5 h. The progress of the reaction was monitored by thin layer chromatography (TLC) to confirm that the reaction was complete. After completion of the reaction, the reaction solution was washed twice with water and then with brine, the organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent ratio of 1:1 ethyl acetate/petroleum ether) to afford ethyl Boc-D-pyroglutamate as a light yellow viscous oil (7.98 g, 95% yield), which solidified to a solid after standing.

References

[1] Patent: WO2007/36730, 2007, A1. Location in patent: Page/Page column 120
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 4, p. 1383 - 1393
[3] Patent: EP1847536, 2007, A1. Location in patent: Page/Page column 28
[4] Patent: US2009/48213, 2009, A1. Location in patent: Page/Page column 70-71
[5] Patent: US2011/34469, 2011, A1. Location in patent: Page/Page column 124

(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate Ethyl D-(-)-pyroglutamate 4-Dimethylaminopyridine Triethylamine Dichloromethane

Preparation Products

(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE Suppliers

Global( 157)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Taizhou Tianhong Biochemistry Technology Co., Ltd.	0523-86132544	sales@thbiochem.com	CHINA	305	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3004	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21189	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21135	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58
Nanjing Fred Technology Co., Ltd.	+86-02584696168 15380713688	Austin@fredchem.cn	CHINA	865	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Taizhou Tianhong Biochemistry Technology Co., Ltd.	60
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58
Nanjing Fred Technology Co., Ltd.	58

View Lastest Price from (R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE 128811-48-3	$100.00	1KG	99%		Career Henan Chemical Co

(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE
128811-48-3
$100.00
99%
Career Henan Chemical Co

(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE Spectrum

(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE(128811-48-3)¹HNMR

128811-48-3((R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE)Related Search:

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1of4

(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE (R)-5-OXO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER METHYL (R)-N-(TERT-BUTOXYCARBONYL)PYROGLUTAMATE Boc-D-Pyroglutamic acid methyl ester Boc-L-pyroglutamic acid methyl ester (R)-1-Tert-butyl2-Methyl5-oxopyrrolidine-1,2-dicarboxylate (R)-N-(tert-butoxycarbonyl)pyroglutaMate 1-Boc-5-oxo-D-proline Methyl ester (2R)-5-oxo-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester 1-tert-butyl 2-methyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate utamic Acid MethyL 1,2-Pyrrolidinedicarboxylic acid, 5-oxo-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R)- (R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE USP/EP/BP -1-tert-Butyl 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate 1-(1,1-Dimethylethyl) 2-methyl (2R)-5-oxo-1,2-pyrrolidinedicarboxylate 128811-48-3