1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE
- CAS No.
- 27258-32-8
- Chemical Name:
- 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE
- Synonyms
- AKOS B007390;3-Formyl-1-methyl-1H-pyrazole;1-Methylpyrazole-3-carbaldehyde;1-Methyl-3-pyrazolecarboxaldehyde;1-Methyl-1H-pyrazol-3-carbaldehyde;1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE;1-methyl-1H-Pyrazole-3-carboxaldehyde;1H-PYRAZOLE-3-CARBOXALDEHYDE, 1-METHYL-
- CBNumber:
- CB1470473
- Molecular Formula:
- C5H6N2O
- Molecular Weight:
- 110.11
- MDL Number:
- MFCD03419800
- MOL File:
- 27258-32-8.mol
| Boiling point | 218.9±13.0℃ (760 Torr) |
|---|---|
| Density | 1.14±0.1 g/cm3 (20 ºC 760 Torr) |
| Flash point | 86.2±19.8℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | liquid |
| pka | 0.06±0.10(Predicted) |
| color | light yellow |
| InChI | InChI=1S/C5H6N2O/c1-7-3-2-5(4-8)6-7/h2-4H,1H3 |
| InChIKey | QUYJEYSRBCLJIZ-UHFFFAOYSA-N |
| SMILES | N1(C)C=CC(C=O)=N1 |
| CAS DataBase Reference | 27258-32-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2933199090 | |||||||||
| NFPA 704 |
|
1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M320938 | 1-Methyl-1H-pyrazole-3-carbaldehyde | 27258-32-8 | 100mg | $60 | 2021-12-16 | Buy |
| TRC | M320938 | 1-Methyl-1H-pyrazole-3-carbaldehyde | 27258-32-8 | 500mg | $90 | 2021-12-16 | Buy |
| AK Scientific | J50385 | 1-Methyl-1H-pyrazole-3-carbaldehyde | 27258-32-8 | 5g | $135 | 2021-12-16 | Buy |
| Matrix Scientific | 074671 | 1-Methyl-1H-pyrazole-3-carbaldehyde 95+% | 27258-32-8 | 5g | $156 | 2021-12-16 | Buy |
| Apolloscientific | OR30991 | 1-Methyl-1H-pyrazole-3-carboxaldehyde | 27258-32-8 | 1g | $73 | 2021-12-16 | Buy |
1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE Chemical Properties,Uses,Production
Synthesis
67751-23-9
60-34-4
27258-32-8
Methylhydrazine (24 cm3, 19.5 g, 0.423 mol) was slowly added dropwise to 225 cm3 of aqueous solution containing 17.0 g NaOH (0.423 mol) under ice bath cooling conditions. Subsequently, 4-(dimethylamino)-1,1-dimethoxy-3-buten-2-one (73.3 g, 0.423 mol) was added slowly dropwise at room temperature and the reaction mixture was stirred overnight. After completion of the reaction, it was cooled to room temperature, 36% HCl (28.2 g, 0.278 mol) was added and stirring was continued for 1 hour. The reaction mixture was extracted with dichloromethane (4 x 100 cm3), the organic phases were combined and dried over anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure and the residue was dissolved in 420 cm3 1M HCl aqueous solution and stirred at room temperature for 3 hours. Subsequently, the pH was adjusted to 10 with 10% K?CO? aqueous solution and extracted with dichloromethane (3 x 200 cm3). The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure. The residue was purified by vacuum distillation to give 1-methyl-1H-pyrazole-3-carbaldehyde (10a). Yield 32.8 g (70% yield); colorless liquid; boiling point: 70-72 °C (3 mbar); mass spectrum (ESI): m/z = 111 ([M + H]?) ; 1H NMR (500 MHz, CDCl?): δ = 9.84 (s, 1H), 7.36 (d, J = 1.4 Hz, 1H), 6.68 (d, J = 1.4 Hz, 1H), 3.91 (s, 3H) ppm; 13C NMR (126 MHz, CDCl?): δ = 185.8, 150.9, 131.8, 105.8, 39.2 ppm.
References
[1] Monatshefte fur Chemie, 2016, vol. 147, # 9, p. 1629 - 1636
1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
View Lastest Price from 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE
27258-32-8
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE
27258-32-8
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co
27258-32-8(1-METHYL-1H-PYRAZOLE-3-CARBALDEHYDE)Related Search:
1of4
