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Diphenylphosphine oxide

Diphenylphosphine oxide Structure
Diphenylphosphine oxide structure
CAS No.
4559-70-0
Chemical Name:
Diphenylphosphine oxide
Synonyms
DPPO;HPOPh2;Diphenylphosphinoxid;GC-DPO;AURORA KA-1314;Diphenylphosphinit;Diphenylphosphorus;TIMTEC-BB SBB005946;Diphenylphosphaneoxide;DIPHENYLPHOSPHINE OXIDE
CBNumber:
CB1471001
Molecular Formula:
C12H11OP
Molecular Weight:
202.19
MDL Number:
MFCD00002079
MOL File:
4559-70-0.mol
MSDS File:
SDS
Last updated:2026-07-26 20:01:22
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Diphenylphosphine oxide Properties

Melting point 56-57 °C(lit.)
Boiling point 102-105°C 0,2mm
refractive index 1.608-1.61
storage temp. Inert atmosphere,Room Temperature
pka 25 (approx)
form Crystals
color Yellow to light orange
Water Solubility Slightly soluble in water.
Sensitive Moisture Sensitive
InChI InChI=1S/C12H11OP/c13-14(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,14H
InChIKey ASUOLLHGALPRFK-UHFFFAOYSA-N
SMILES P(=O)(C1=CC=CC=C1)C1=CC=CC=C1
CAS DataBase Reference 4559-70-0(CAS DataBase Reference)
FDA UNII XXW49HG6X3
UNSPSC Code 12352002
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
WGK Germany  2
HS Code  29319090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

Diphenylphosphine oxide price More Price(81)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 287881 Diphenylphosphine oxide 97% 4559-70-0 1g $85.7 2026-04-30 Buy
Sigma-Aldrich 287881 Diphenylphosphine oxide 97% 4559-70-0 5g $186 2026-04-30 Buy
TCI Chemical D2826 Diphenylphosphine Oxide >98.0%(GC) 4559-70-0 5g $146 2026-04-30 Buy
TCI Chemical D2826 Diphenylphosphine Oxide >98.0%(GC) 4559-70-0 25g $501 2026-04-30 Buy
Usbiological 273793 Diphenylphosphine oxide Asreported 4559-70-0 1g $347 2026-06-03 Buy
Product number Packaging Price Buy
287881 1g $85.7 Buy
287881 5g $186 Buy
D2826 5g $146 Buy
D2826 25g $501 Buy
273793 1g $347 Buy

Diphenylphosphine oxide Chemical Properties, Uses, Production

Chemical Properties

Yellow to light orange crystals

Uses

suzuki reaction

Uses

Used in the preparation of triarylphosphine oxides, and as asymmetric catalysts, preparation of alkenyldiphenylphosphine oxides, and Horner-Wittig reagents. It is a ligand for Buchwald-Hartwig Cross Coupling Reaction, Hydrophosphonylations and Suzuki-Miyaura Coupling.

Definition

ChEBI: Diphenylphosphine oxide is a member of benzenes.

Synthesis Reference(s)

Journal of the American Chemical Society, 45, p. 165, 1923 DOI: 10.1021/ja01654a024

reaction suitability

reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction
reagent type: ligand
reaction type: Hydrophosphonylations
reagent type: ligand
reaction type: Suzuki-Miyaura Coupling

Synthesis

There are three main methods for the synthesis of diphenylphosphine oxide. Method 1 is to use POCl3 as raw material, after Foucault alkylation reaction, lithium aluminum hydride reduction to get the target; method 2 is to use diethyl phosphite as raw material, the reaction of Gram's reagent to generate the product; method 3 by Miller et al. to use PCl3 as raw material, after Foucault alkylation reaction, and then the target by the appropriate hydrolysis, but its intermediate Ph2PCl purification is more difficult, and the yield is low, only 37.0%. only 37.0%.

Diphenylphosphine oxide Preparation Products And Raw materials

Raw materials

Ethanol Sodium Bromobenzene Phosphorus trichloride Tetrahydrofuran
Ethyl acetate Diethyl phosphite Hydrochloric acid Dichloromethane Sodium hydroxide
Petroleum ether Magnesium Lithium

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Preparation Products

1,2-Bis(diphenylphosphinomethyl)benzene 2-(Diphenylphosphino)-biphenyl (Diphenylphosphoryl)methanol (3R-trans)-[2-[3,5-Bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]cyclohexylidene]ethyl]diphenyl-phosphine Oxide

Diphenylphosphine oxide Suppliers

Global Suppliers ( 399)
Supplier Tel Email Country ProdList Advantage
Qingdao Yuqing Chemical Technology Co.,Ltd 19353227317 19353227317 yuqinghuagong@163.com China 25 58
Zhejiang Shouerfu Chemical Trade Co. Ltd. 0571-88906230 shenlu@shoufuchem.com China 493 58
Baoding Bink New Materials Co., Ltd. 17531153977 allison@yan-xi.com China 315 58
Shanghai Jiuju Chemical Technology Co. LTD 021-54290889 18117093889;17717355955 1261932215@qq.com China 397 58
Shijiazhuang Jianxin Biotechnology Co., LTD 0311-1906231-3169 19062313169 19062313169@163.com China 397 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Beijing Donghualituo Techonlogy Development Co.,Ltd. 010-88425576 sales@dhltchem.com China 793 59
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Supplier Advantage
Qingdao Yuqing Chemical Technology Co.,Ltd 58
Zhejiang Shouerfu Chemical Trade Co. Ltd. 58
Baoding Bink New Materials Co., Ltd. 58
Shanghai Jiuju Chemical Technology Co. LTD 58
Shijiazhuang Jianxin Biotechnology Co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Beijing Donghualituo Techonlogy Development Co.,Ltd. 59
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81

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View Latest Price from Diphenylphosphine oxide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Diphenylphosphine oxide pictures 2026-10-13 Diphenylphosphine oxide
4559-70-0
 $75.00-100.00 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Diphenylphosphine oxide pictures 2026-09-02 Diphenylphosphine oxide
4559-70-0
 $1.00-200.00 1KG 99%, 99.5% Sublimated Henan Fengda Chemical Co., Ltd
Diphenylphosphine oxide pictures 2026-08-25 Diphenylphosphine oxide
4559-70-0
 $1.10-9.90 1KG 99%min 100KG ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Diphenylphosphine oxide Spectrum

Diphenylphosphine oxide(4559-70-0)1HNMRDiphenylphosphine oxide(4559-70-0)RamanDiphenylphosphine oxide(4559-70-0)IR

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Diphenylphosphonousacid Diphenylphosphineoxide,97% Diphenylphosphine oxide 97% Two phenylphosphate oxygen Phosphine oxide,diphenyl- TIMTEC-BB SBB005946 Diphenylphosphaneoxide Diphenylphosphinigsαure AURORA KA-1314 DIPHENYLPHOSPHINE OXIDE Diphenylphosphinit Diphenylphosphinousacid GC-DPO DiphenylphosphineoxideGradeB97% 2,4-dinitro-N-[(E)-3,3,3-trifluoropropylideneamino]aniline Diphenylphosphorus DiphenylphosphineOxide> Diphenylphosphine oxide, 98%, for synthesis Diphenylphosphine oxide, 97%, for synthesis Diphenylphosphine oxide// DPPO DIPHENYLPHOSPHINE OXIDE 90% MIN Diphenylphosphinoxid DPPO HPOPh2 4559-70-0 4559-70-7 C6H52POH C12H11OP C12H10OP Catalysis and Inorganic Chemistry Phosphorus Compounds Phosphorus Precursors Phosphorus Compounds Phosphorus Precursors Achiral Phosphine Aryl Phosphine Pharmaceutical Intermediates Catalysis and Inorganic Chemistry