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4'-Fluoropropiophenone

4'-Fluoropropiophenone structure

CAS No.: 456-03-1

Chemical Name:: 4'-Fluoropropiophenone

Synonyms: 1-(4-fluorophenyl)propan-1-one;p-fluorophenone;Fluorophenylacetone;P-FLUOROPROPIOPHENONE;4-FLUOROPROPIOPHENONE;LABOTEST-BB LT01148316;4'-fluoropropiophenone;para-Fluoropropiophenone;4-Fluoropropiophenone99%;Propiophenone, 4'-fluoro-

CBNumber:: CB1700848

Molecular Formula:: C9H9FO

Molecular Weight:: 152.17

MDL Number:: MFCD00000356

MOL File:: 456-03-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:44:55

Product description	Number	Pack Size	Price
4′-Fluoropropiophenone 98%	128414	5g	$48.3
4'-Fluoropropiophenone >97.0%(GC)	F0522	5g	$17
4'-Fluoropropiophenone >97.0%(GC)	F0522	25g	$23
4'-Fluoropropiophenone 98%	PC4190	25g	$35
4'-Fluoropropiophenone 98%	PC4190	100g	$69
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4'-Fluoropropiophenone Properties

Boiling point	100-102 °C (22 mmHg)
Density	1.096 g/mL at 25 °C (lit.)
refractive index	n20/D 1.5059(lit.)
Flash point	170 °F
storage temp.	Inert atmosphere,Room Temperature
form	clear liquid
color	Colorless to Light orange to Yellow
Specific Gravity	1.096
BRN	1210310
InChI	InChI=1S/C9H9FO/c1-2-9(11)7-3-5-8(10)6-4-7/h3-6H,2H2,1H3
InChIKey	QIJNVLLXIIPXQT-UHFFFAOYSA-N
SMILES	C(C1=CC=C(F)C=C1)(=O)CC
CAS DataBase Reference	456-03-1(CAS DataBase Reference)
FDA UNII	FM9L77MB6C
NIST Chemistry Reference	1-Propanone, 1-(4-fluorophenyl)-(456-03-1)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H227-H319-H302-H315-H318-H335

Precautionary statements

P261-P280-P305+P351+P338-P210e-P280a-P405-P501a-P210-P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,Xi

Risk Statements

22-37/38-41-36/37/38

Safety Statements

26-39-37/39

RIDADR

2735

WGK Germany

Hazard Note

Irritant

HS Code

29147000

Storage Class

10 - Combustible liquids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

4'-Fluoropropiophenone price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	128414	4′-Fluoropropiophenone 98%	456-03-1	5g	$48.3	2023-01-07	Buy
TCI Chemical	F0522	4'-Fluoropropiophenone >97.0%(GC)	456-03-1	5g	$17	2026-04-30	Buy
TCI Chemical	F0522	4'-Fluoropropiophenone >97.0%(GC)	456-03-1	25g	$23	2026-04-30	Buy
Apolloscientific	PC4190	4'-Fluoropropiophenone 98%	456-03-1	25g	$35	2026-06-04	Buy
Apolloscientific	PC4190	4'-Fluoropropiophenone 98%	456-03-1	100g	$69	2026-06-04	Buy

Product number	Packaging	Price	Buy
128414	5g	$48.3	Buy
F0522	5g	$17	Buy
F0522	25g	$23	Buy
PC4190	25g	$35	Buy
PC4190	100g	$69	Buy

4'-Fluoropropiophenone Chemical Properties,Uses,Production

Chemical Properties

clear yellow liquid after melting

Uses

4′-Fluoropropiophenone was used in the preparation of 2-(4-fluorophenyl)-3-methylquinoxaline.

Synthesis

5724-03-8

456-03-1

General procedure for the synthesis of 4'-fluoropropiophenone from 1-(4-fluorophenyl)prop-2-en-1-ol: Under nitrogen protection, the ruthenium complex [RuCl2(6-C6H6)(PTA-Me)] (3a) (0.02-0.1 mmol; 0.5-2.5 mol%) and K2CO3 (0.05-0.25 mmol) were added to a solution of 1-(4-fluorophenyl)prop-2-en-1-ol (4a-o, 4 mmol) in tetrahydrofuran (4mL). -fluorophenyl)prop-2-en-1-ol (4a-o, 4 mmol) in a solution of tetrahydrofuran (4 mL). The reaction mixture was placed in a sealed tube and stirred at 75°C for the indicated time (see Table 4 and Scheme 3). The progress of the reaction was monitored by sampling and diluting 10 μL of the sample with dichloromethane (3 mL) every ~1 hr followed by GC analysis. Upon completion of the reaction, the mixture was cooled to room temperature, at which point the ruthenium complex 3a partially precipitated. The solids were removed by filtration and the reaction products were subsequently separated by solvent evaporation. The residue was purified using silica gel column chromatography with EtOAc-hexane (1:10) mixed solvent as eluent. The structure of the resulting carbonyl compounds 5a-o was confirmed by GC/MS analysis of their fragmentation patterns, NMR spectroscopy, and comparison of retention times of commercially pure samples (Sigma-Aldrich or Acros Organics).

References

[1] Tetrahedron, 2008, vol. 64, # 51, p. 11745 - 11750
[2] Journal of Molecular Catalysis A: Chemical, 2013, vol. 366, p. 390 - 399
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 26, p. 3886 - 3895
[4] Green Chemistry, 2010, vol. 12, # 9, p. 1628 - 1633
[5] Organometallics, 2012, vol. 31, # 23, p. 8301 - 8311

4'-Fluoropropiophenone synthesis

Synthesis of 4'-Fluoropropiophenone from Methanol and 1-(4-Fluorophenyl)ethanol

4'-Fluoropropiophenone Preparation Products And Raw materials

Raw materials

Benzenemethanol, α-ethenyl-4-fluoro- Ethylmagnesium bromide 4-Fluoro-N-methoxy-N-methylbenzamide Methanol Tetrahydrofuran

Potassium carbonate 1-(4-Fluorophenyl)ethanol Propionyl chloride Fluorobenzene

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Preparation Products

4-phenoxypropiophenone

4'-Fluoropropiophenone Suppliers

Global( 244)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xiamen Wonderful Bio Technology Co., Ltd.	+8613043004613	Sara@xmwonderfulbio.com	China	283	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	Brad@rongnabiotech.com	China	3373	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Cangzhou Wanyou New Material Technology Co.,Ltd	18631714998	sales@czwytech.com	CHINA	904	58
Shanghai Longyu Biotechnology Co., Ltd.		info@longyupharma.com	China	2430	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Hebei shuoxi biotechnology co. LTD	+8613081092107		CHINA	964	58

Supplier	Advantage
Xiamen Wonderful Bio Technology Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
RongNa Biotechnology Co.,Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Cangzhou Wanyou New Material Technology Co.,Ltd	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Hebei shuoxi biotechnology co. LTD	58

View Lastest Price from 4'-Fluoropropiophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-25	4'-Fluoropropiophenone 456-03-1	$10.00	1ASSAYS	99%	10 ton	RongNa Biotechnology Co.,Ltd
2026-05-28	4'-Fluoropropiophenone 456-03-1	$19.00	1kg	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2026-03-20	4'-Fluoropropiophenone 456-03-1		1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

4'-Fluoropropiophenone
456-03-1
$10.00
99%
RongNa Biotechnology Co.,Ltd

4'-Fluoropropiophenone
456-03-1
$19.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

4'-Fluoropropiophenone
456-03-1
99%
Hebei Chuanghai Biotechnology Co., Ltd

4'-Fluoropropiophenone Spectrum

4'-Fluoropropiophenone(456-03-1)MS 4'-Fluoropropiophenone(456-03-1)¹HNMR 4'-Fluoropropiophenone(456-03-1)¹³CNMR 4'-Fluoropropiophenone(456-03-1)IR1 4'-Fluoropropiophenone(456-03-1)Raman

456-03-1(4'-Fluoropropiophenone)Related Search:

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P-FLUOROPROPIOPHENONE ETHYL 4-FLUOROPHENYL KETONE LABOTEST-BB LT01148316 4-FLUOROPROPIOPHENONE 1-(4-Fluorophenyl)-1-propanone 1-Propanone,1-(4-fluorophenyl)- para-Fluoropropiophenone Propiophenone, 4'-fluoro- 4-Fluoropropiophenone99% 4-Fluoropropiophenone 99% 4'-Fluoropropiophenone,97+% Ethyl p-fluorophenyl ketone 4'-difluoroaMilineacetone The fluorine benzene acetone 4-amino-3-(phenoxymethyl)-1H-1,2,4-triazole-5-thione 4'-Fluoropropiophenone > 4'-Fluoropropiophenone USP/EP/BP High Quality 4'-Fluoropropiophenone 99% purity 4'-Fluoropropiophenone 4'-fluoropropiophenone p-fluorophenone 4'-Fluoropropiophenone, 98% 4′-Fluoropropiophenone, CAS 456-03-1 Fluorophenylacetone 4-Fluoropropiophenone 99% 1-(4-fluorophenyl)propan-1-one 456-03-1 Building Blocks C9 Carbonyl Compounds Ketones Organic Building Blocks C9 Carbonyl Compounds Ketones Fluorine Compounds Aromatic Ketones (substituted) ketone Fluorobenzene Acetophenone Series Adehydes, Acetals & Ketones 456-03-1