1-(4-Fluoro-phenyl)-butan-1-one
- CAS No.
- 582-83-2
- Chemical Name:
- 1-(4-Fluoro-phenyl)-butan-1-one
- Synonyms
- p-Fluorobutyrophenone;2-methyl-1-propen-1-ol;4'-fluorobutyrophenone;4'-Fluorobutyrophenone;Butyrophenone, 4'-fluoro-;4'-Fluorobutyrophenone 98%;p-Fluorophenylpropyl ketone;1-(4-Fluorophenyl)-1-butanone;1-Butanone, 1-(4-fluorophenyl)-;1-(4-Fluoro-phenyl)-butan-1-one
- CBNumber:
- CB9762790
- Molecular Formula:
- C10H11FO
- Molecular Weight:
- 166.19
- MDL Number:
- MFCD00017967
- MOL File:
- 582-83-2.mol
- MSDS File:
- SDS
| Melting point | 38 °C |
|---|---|
| Boiling point | 102 °C |
| Density | 1.050±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| Water Solubility | Insoluble in water. |
| CAS DataBase Reference | 582-83-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2914790090 | |||||||||
| NFPA 704 |
|
1-(4-Fluoro-phenyl)-butan-1-one price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S415456 | 4'-FLUOROBUTYROPHENONE AldrichCPR | 582-83-2 | 1 unit | $121 | 2026-04-30 | Buy |
| Sigma-Aldrich | S415456 | 4'-FLUOROBUTYROPHENONE Aldrich | 582-83-2 | 50mg | $110 | 2024-03-01 | Buy |
| Apolloscientific | PC6692 | 4'-Fluorobutyrophenone 98% | 582-83-2 | 10g | $293 | 2026-06-04 | Buy |
| Apolloscientific | PC6692 | 4'-Fluorobutyrophenone 98% | 582-83-2 | 25g | $521 | 2026-06-04 | Buy |
| SynQuest Laboratories | 2617-3-44 | 4'-Fluorobutyrophenone 98% | 582-83-2 | 25g | $275 | 2026-05-22 | Buy |
1-(4-Fluoro-phenyl)-butan-1-one Chemical Properties, Uses, Production
Uses
4'-fluorobutyrophenone derivatives is used in the preparation of its derivatives that includes haloperidol, haloanisone, triperidol, methylperidide, haloperidide and dipiperone.
Synthesis
462-06-6
141-75-3
582-83-2
In a 500 mL four-necked flask, n-butyryl chloride (55.5 g, 0.52 mol) was dissolved in ethylene dichloride (250 mL), stirred well, and cooled to about 10°C. Fluorobenzene (52.1 g, 0.57 mol) was dissolved in 100 mL of ethylene dichloride, prepared as a solution and then slowly added dropwise to the n-butyryl chloride solution. After the dropwise addition was completed, the reaction mixture was heated and the reaction process was monitored by thin layer chromatography (TLC) or gas chromatography (GC). Upon completion of the reaction, the reaction solution was poured into a mixture of dilute hydrochloric acid and ice, stirred for 1 hour, and left to stratify. The organic phase was separated and washed sequentially with water and saturated sodium carbonate solution. The solvent was removed by distillation under reduced pressure, and the fraction at 102~105°C/9 mmHg was collected to give 77.8 g of 4-fluorobutyrophenone in 90% yield and 99.0% purity.
References
[1] Patent: CN105384707, 2016, A. Location in patent: Paragraph 0003; 0026
[2] Patent: WO2018/165520, 2018, A1. Location in patent: Page/Page column 159
[3] Recueil des Travaux Chimiques des Pays-Bas, 1949, vol. 68, p. 781,785
[4] Archiv der Pharmazie, 1963, vol. 296, p. 324 - 336
[5] Patent: CN104974053, 2017, B. Location in patent: Paragraph 0062; 0063
1-(4-Fluoro-phenyl)-butan-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Tianjin Chempharmatech Co.,Ltd. | 022-66211079 13212288319 | sales@chempharmatech.com | China | 943 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Quzhou Rundong Chemical (Technology) Co. | 0570-8789886 18892685668 | info@rundongchemical.com | China | 4045 | 60 |
| Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 | synchempharma@aliyun.com | China | 4988 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
