3-BROMO-4-FORMYLTHIOPHENE
- CAS No.
- 18791-78-1
- Chemical Name:
- 3-BROMO-4-FORMYLTHIOPHENE
- Synonyms
- 4-BROMOTHIOPHENE-3-CARBALDEHYDE;4-Bromothiophene-3-carboxaldehyde;CHEMBRDG-BB 4300332;3-BROMO-4-FORMYLTHIOPHENE;4-bromo-3-formylthiophene;4-BROMO-3-THIOPHENECARBALDEHYDE;3- bromothiophene -4- formaldehyde;3-Thiophenecarboxaldehyde, 4-bromo-;4-Bromothiophene-3-carboxaldehyde >4-bromothiophene-3-carbaldehyde(SALTDATA: FREE)
- CBNumber:
- CB1753743
- Molecular Formula:
- C5H3BrOS
- Molecular Weight:
- 191.05
- MDL Number:
- MFCD01318960
- MOL File:
- 18791-78-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Bromothiophene-3-carboxaldehyde >97.0%(GC) | B4126 | 200mg | $89 |
| 4-Bromothiophene-3-carboxaldehyde >97.0%(GC) | B4126 | 1g | $360 |
| 4-Bromo-3-thiophenecarbaldehyde | 161265 | 250mg | $531 |
| 4-Bromothiophene-3-carbaldehyde 97% | AS48708 | 1g | $70 |
| 4-Bromothiophene-3-carbaldehyde 97% | AS48708 | 5g | $245 |
| More product size | |||
| Boiling point | 96°/5mm |
|---|---|
| Density | 1.789±0.06 g/cm3(Predicted) |
| refractive index | 1.6310 to 1.6350 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | clear liquid |
| color | Light yellow to Yellow to Orange |
| InChI | 1S/C5H3BrOS/c6-5-3-8-2-4(5)1-7/h1-3H |
| InChIKey | ZDVHJQOCVBTMOF-UHFFFAOYSA-N |
| SMILES | Brc1cscc1C=O |
| CAS DataBase Reference | 18791-78-1 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xi |
| HazardClass | IRRITANT |
| HS Code | 2934999090 |
3-BROMO-4-FORMYLTHIOPHENE price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4126 | 4-Bromothiophene-3-carboxaldehyde >97.0%(GC) | 18791-78-1 | 200mg | $89 | 2024-03-01 | Buy |
| TCI Chemical | B4126 | 4-Bromothiophene-3-carboxaldehyde >97.0%(GC) | 18791-78-1 | 1g | $360 | 2026-04-30 | Buy |
| Usbiological | 161265 | 4-Bromo-3-thiophenecarbaldehyde | 18791-78-1 | 250mg | $531 | 2026-06-03 | Buy |
| Activate Scientific | AS48708 | 4-Bromothiophene-3-carbaldehyde 97% | 18791-78-1 | 1g | $70 | 2026-06-04 | Buy |
| Activate Scientific | AS48708 | 4-Bromothiophene-3-carbaldehyde 97% | 18791-78-1 | 5g | $245 | 2026-06-04 | Buy |
3-BROMO-4-FORMYLTHIOPHENE Chemical Properties,Uses,Production
Uses
3-BroMo-4-forMylthiophene is used in the dehalogenation and hydrogenation of halogenated heteroatom aldehydes. Also used in the production of NIR-absorbing polycarboxylic acids as polymer dye fo r dye sensitized solar cells.
Synthesis
3141-26-2
68-12-2
18791-78-1
1. A stirred solution of thiophene (185 mL, 2.3 mol) in chloroform was treated dropwise with bromine (500 mL, 1560 g, 9.75 mol) for 5 hours at 0°C. The solution was then cooled to a temperature of 0.5°F. During the last hour, cooling was stopped and the addition of bromine continued. 2. The reaction mixture was stirred and heated to reflux for 5 h. After cooling to room temperature, the reaction mixture was quenched with 3 M aqueous NaOH solution with vigorous stirring to consume excess bromine. The aqueous layer was separated and the organic phase was washed sequentially with water and acetone (150 mL) to remove residual water. 3. After drying the organic residue, it was dissolved in chloroform (1 L) at reflux. After cooling, tetrabromothiophene precipitated as colorless crystals (693 g, 75% yield). 4. Tetrabromothiophene (47 g, 0.12 mol) was dissolved in anhydrous ethyl ether (300 mL), cooled to 0 °C, and butyllithium solution (150 mL, 0.24 mol, 1.6 M) in hexanes was added drop-wise under argon protection over 80-90 min. 5. After continued stirring for 20 min, ice water (250 mL) was carefully added. The organic phase was separated and the aqueous phase was extracted twice with ether, the organic extracts were combined, dried with anhydrous calcium chloride and concentrated in vacuum. 6. The residue was distilled at 15 mmHg to give 3,4-dibromothiophene (22 g, 77% yield). 7. 3,4-dibromothiophene (72 g, 0.3 mol) was dissolved in anhydrous ether (120 mL), cooled to -78 °C, a solution of nBuLi (206 mL, 0.33 mol, 1.6 M) was added, and stirred at -78 °C for 5 min. 8. slowly add anhydrous ether (120 mL) solution of DMF (35 mL, 0.45 mol) cooled to -78 °C. After 10 min remove the cold bath and carefully add aqueous 6N HCl (150 mL), warm to 23 °C. 9. The aqueous phase was separated, the organic phase was washed with ether, the organic extracts were combined, washed with saturated aqueous sodium bicarbonate and the organic solvent was evaporated. 10. The residue was distilled twice under vacuum to give pure 3-bromothiophene-4-carbaldehyde (40 g, 69% yield).
References
[1] Organic and Biomolecular Chemistry, 2011, vol. 9, # 23, p. 8016 - 8029
[2] RSC Advances, 2015, vol. 5, # 77, p. 62336 - 62342
[3] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 6, p. 3682 - 3688
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994, # 19, p. 2735 - 2744
[5] Chemistry - A European Journal, 2016, vol. 22, # 2, p. 694 - 703
3-BROMO-4-FORMYLTHIOPHENE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9976 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178 | peter68@ptchemgroup.com | China | 35405 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49859 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501 | product@acmec-e.com | China | 33301 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 |
View Lastest Price from 3-BROMO-4-FORMYLTHIOPHENE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-02 | 3-BROMO-4-FORMYLTHIOPHENE
18791-78-1
|
$1.00 | 1KG | 98% | 1kg; 2kg；10kg; 100kg | Career Henan Chemical Co |
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- 3-BROMO-4-FORMYLTHIOPHENE
18791-78-1
- $1.00
- 98%
- Career Henan Chemical Co
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