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2-Chloro-4-fluorobenzoic acid

2-Chloro-4-fluorobenzoic acid Structure
2-Chloro-4-fluorobenzoic acid structure
CAS No.
2252-51-9
Chemical Name:
2-Chloro-4-fluorobenzoic acid
Synonyms
MINA-008;RARECHEM AL BO 0405;TIMTEC-BB SBB003795;1-chloro-2-fluorobezene;2-Chloro-4-Fluorobenzoic;Mefenamic Acid Impurity 61;2-Choro-4-fluorobenzoic acid;2-chloro-4-fluorobenzioc acid;2-CHLORO-4-FLUOROBENZOIC ACID;2-Chloro-4-fluorobenzoicacid99%
CBNumber:
CB3413667
Molecular Formula:
C7H4ClFO2
Molecular Weight:
174.56
MDL Number:
MFCD00010615
MOL File:
2252-51-9.mol
MSDS File:
SDS
Last updated:2026-05-28 06:28:37
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2-Chloro-4-fluorobenzoic acid Properties

Melting point 181-183 °C (lit.)
Boiling point 271.9±20.0 °C(Predicted)
Density 1.4016 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility 95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to very faintly yellow
pka 2.90±0.25(Predicted)
form Powder or Flakes
color White
BRN 1946215
InChI InChI=1S/C7H4ClFO2/c8-6-3-4(9)1-2-5(6)7(10)11/h1-3H,(H,10,11)
InChIKey GRPWQLDSGNZEQE-UHFFFAOYSA-N
SMILES C(O)(=O)C1=CC=C(F)C=C1Cl
CAS DataBase Reference 2252-51-9(CAS DataBase Reference)
NIST Chemistry Reference 2-Chloro-4-fluorobenzoic acid(2252-51-9)
EPA Substance Registry System Benzoic acid, 2-chloro-4-fluoro- (2252-51-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P261-P280-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-37/38-41-36/37/38
Safety Statements  26-36/37/39-37/39-36
WGK Germany  3
TSCA  TSCA listed
HazardClass  IRRITANT
HS Code  29163990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
0
2 0

2-Chloro-4-fluorobenzoic acid price More Price(66)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 297836 2-Chloro-4-fluorobenzoic acid 99% 2252-51-9 25g $121 2026-04-30 Buy
TCI Chemical C1350 2-Chloro-4-fluorobenzoic Acid >98.0%(GC)(T) 2252-51-9 5g $45 2026-04-30 Buy
TCI Chemical C1350 2-Chloro-4-fluorobenzoic Acid >98.0%(GC)(T) 2252-51-9 25g $121 2026-04-30 Buy
Usbiological 267415 2-Chloro-4-fluorobenzoic acid Asreported 2252-51-9 25g $307 2026-06-03 Buy
Usbiological 267415 2-Chloro-4-fluorobenzoic acid Asreported 2252-51-9 50g $415 2026-06-03 Buy
Product number Packaging Price Buy
297836 25g $121 Buy
C1350 5g $45 Buy
C1350 25g $121 Buy
267415 25g $307 Buy
267415 50g $415 Buy

2-Chloro-4-fluorobenzoic acid Chemical Properties,Uses,Production

Chemical Properties

Powder or crystalline or flakes

Uses

2-Chloro-4-fluorobenzoic acid was used in the preparation of 2-(2-chloro-4-fluorophenyl)-benzothiazole.

Application

2-Chloro-4-fluorobenzoic acid can be used as:
(1) Studies on the preparation, luminescence and thermal properties of lanthanide complexes of 2-chloro-4-fluorobenzoic acid.
(2) Preparation, crystal structure, thermal and fluorescence property studies of rare earth complexes composed with 2,2':6′,2″-tripyridine.
(3) Analysis of charge density of intermolecular interactions between isohalogen (Cl--F) and homohalogen (F--F) molecules in molecular crystals. Attractive intermolecular Cl--F interactions (type II interactions) in 2-chloro-4-fluorobenzoic acid.

Synthesis

2-Chloro-4-fluorobenzoic acid is synthesized from m-chloroaniline in four steps. 1) m-Chloroaniline reacts with 2-(trimethylsilyl)ethoxymethyl chloride in the presence of potassium carbonate, potassium iodide, and ionic liquid to give N,N-bis(trimethylsilyl)ethoxymethyl-3-chloroaniline. 2) The product from step 1 reacts with titanium tetrachloride in ionic liquid to yield 4-bis(trimethylsilyl)ethoxymethylamino-2-chlorobenzaldehyde. 3) This aldehyde reacts with hydrogen peroxide and triphenylphosphine rhodium chloride in organic solvent, followed by pressurized hydrogenation with hydrogen. Work-up gives 4-amino-2-chlorobenzoic acid. 4) This acid reacts with hydrogen peroxide in ionic liquid. Potassium fluoride and phosphotungstic heteropoly acid ammonium salt are then added. Work-up yields 2-chloro-4-fluorobenzoic acid.

2-Chloro-4-fluorobenzoic acid synthesis

84194-36-5
2252-51-9
Synthesis of 2-Chloro-4-fluorobenzoic acid from 2-Chloro-4-fluorobenzaldehyde

2-Chloro-4-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

carbon monoxide 2-Chloro-4-fluorobenzaldehyde 4-Amino-2-chlorobenzoic acid 2-Chloro-4-fluoroiodobenzene Palladium (II) Acetate
Water 1,4-Dioxane Triphenylphosphine Triethylamine

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Preparation Products

2-Chloro-4-fluorobenzyl alcohol Flosequinan (5-Bromo-2-chloro-4-fluoro-phenyl)-methanol tert-Butyl2-chloro-4-fluoroBenzoate

2-Chloro-4-fluorobenzoic acid Suppliers

Global( 502)Suppliers
Supplier Tel Email Country ProdList Advantage
CHANGZHOU FLUORIDE CHEMICAL CO.,LTD 0086-519-89892883 15995021858 info@fluoridechem.com China 79 58
Qi-Chem Co., Ltd. 0411-88165951 13601035838 marketing@qi-chem.com China 167 58
Shanghai Qianhe Biological Technology Co., Ltd. 021-58337595 13621714589 93732879@qq.com China 242 58
China Synchem Technology Co.,Ltd. +86-0552-4929304 +86-18055277008 sales@cnsynchem.com China 55 65
Anhui Yongsheng Pharmaceutical Technology Co., Ltd 3307 18017383231 983544897@qq.com China 941 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
Supplier Advantage
CHANGZHOU FLUORIDE CHEMICAL CO.,LTD 58
Qi-Chem Co., Ltd. 58
Shanghai Qianhe Biological Technology Co., Ltd. 58
China Synchem Technology Co.,Ltd. 65
Anhui Yongsheng Pharmaceutical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56

View Lastest Price from 2-Chloro-4-fluorobenzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-4-fluorobenzoic acid pictures 2026-09-11 2-Chloro-4-fluorobenzoic acid
2252-51-9
 $90.00 1KG 99% 300MT/year Speranza Chemical Co., Ltd.
2-Chloro-4-fluorobenzoic acid pictures 2026-09-11 2-Chloro-4-fluorobenzoic acid
2252-51-9
 1KG 99.0% 1000kg/month WUHAN FORTUNA CHEMICAL CO., LTD
2-Chloro-4-fluorobenzoic acid pictures 2026-09-02 2-Chloro-4-fluorobenzoic acid
2252-51-9
 $5.00 1KG 99% Henan Fengda Chemical Co., Ltd

2-Chloro-4-fluorobenzoic acid Spectrum

2-Chloro-4-fluorobenzoic acid(2252-51-9)MS2-Chloro-4-fluorobenzoic acid(2252-51-9)1HNMR2-Chloro-4-fluorobenzoic acid(2252-51-9)13CNMR2-Chloro-4-fluorobenzoic acid(2252-51-9)IR12-Chloro-4-fluorobenzoic acid(2252-51-9)IR22-Chloro-4-fluorobenzoic acid(2252-51-9)Raman

2252-51-9(2-Chloro-4-fluorobenzoic acid)Related Search:

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2-Chloro-4-fluorobenzonitrile 4-Bromo-2-fluorobenzoic acid (+)-Menthyl chloroformate

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2-CHLORO-4-FLUOROBENZOIC ACID Benzoic acid, 2-chloro-4-fluoro- 1-chloro-2-fluorobezene 2-Chloro-4-Fluorobenzoic 2-Chloro-4-fluorobenzoic acid 99% 2-Chloro-4-fluorobenzoicacid99% 2-CHLORO-4-FLUROBENZOIC ACID pure TIMTEC-BB SBB003795 RARECHEM AL BO 0405 2-chloro-4-fluorobenzioc acid 2-Chloro-4-fluorobenzoic Acid > 2-Chloro-4-Fluoro Benzoic Acid pure, 98% MINA-008 2-Choro-4-fluorobenzoic acid Mefenamic Acid Impurity 61 2252-51-9 ClC6H3FCO2H Organic Building Blocks C7 Carboxylic Acids Carbonyl Compounds Building Blocks Fluorine series Carbonyl Compounds Carboxylic Acids FINE Chemical & INTERMEDIATES blocks Carboxes FluoroCompounds C7 Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts Benzoic acid Fluorobenzene Miscellaneous Acids & Esters Chlorine Compounds Fluorine Compounds bc0001 pharmaceutical