ChemicalBook >> CAS DataBase List >>3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid

3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid

3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid structure

CAS No.: 202467-69-4

Chemical Name:: 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid

Synonyms: Ertapenem side chain;ERTAPENEM SIDE CHAIN 1;SIDE CHAIN FOR ERTAPENEM;Ertaipenem side chain;Ertapenem side chains;SIDECHAINIFORERTAPENEM;Side Train of Ertapenem;Side Chain of ErtapeneM;Etapec South Side Chain;E he pei south side chain

CBNumber:: CB1855069

Molecular Formula:: C20H19N3O7S

Molecular Weight:: 445.45

MDL Number:: MFCD09263754

MOL File:: 202467-69-4.mol

MSDS File:: SDS

Last updated:2026-05-27 23:51:10

Request For Quotation

3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid Properties

Boiling point	749.6±60.0 °C(Predicted)
Density	1.50±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO, Methanol (Sparingly)
pka	4.06±0.10(Predicted)
form	Solid
color	Off-White
InChIKey	RTQKWWOSWDCUMA-IRXDYDNUSA-N
SMILES	N1(C(OCC2=CC=C([N+]([O-])=O)C=C2)=O)C[C@@H](S)C[C@H]1C(NC1=CC=CC(C(O)=O)=C1)=O
CAS DataBase Reference	202467-69-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P280-P305+P351+P338

3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-N494590-250MG	3-[[[(2S,4S)-1-(4-Nitrobenzyloxycarbonyl)-4-mercaptopyrrolidin-2-yl]carbonyl]amino]benzoic Acid	202467-69-4	250mg	$179	2026-06-03	Buy
TRC	TRC-N494590-1G	3-[[[(2S,4S)-1-(4-Nitrobenzyloxycarbonyl)-4-mercaptopyrrolidin-2-yl]carbonyl]amino]benzoic Acid	202467-69-4	1g	$334	2026-06-03	Buy
TRC	TRC-N494590-100MG	3-[[[(2S,4S)-1-(4-Nitrobenzyloxycarbonyl)-4-mercaptopyrrolidin-2-yl]carbonyl]amino]benzoic Acid	202467-69-4	100mg	$154	2026-06-03	Buy
Matrix Scientific	092423	3-((2S,4S)-4-Mercapto-1-(((4-nitrobenzyl)oxy)-carbonyl)pyrrolidine-2-carboxamido)benzoic acid	202467-69-4	1.00g	$117	2026-05-18	Buy
Matrix Scientific	092423	3-((2S,4S)-4-Mercapto-1-(((4-nitrobenzyl)oxy)-carbonyl)pyrrolidine-2-carboxamido)benzoic acid	202467-69-4	5.00g	$420	2026-05-18	Buy

Product number	Packaging	Price	Buy
TRC-N494590-250MG	250mg	$179	Buy
TRC-N494590-1G	1g	$334	Buy
TRC-N494590-100MG	100mg	$154	Buy
092423	1.00g	$117	Buy
092423	5.00g	$420	Buy

3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid Chemical Properties, Uses, Production

Uses

3-[[[(2S,4S)-1-(4-Nitrobenzyloxycarbonyl)-4-mercaptopyrrolidin-2-yl]carbonyl]amino]benzoic Acid is an intermediate in the preparation of Ertapenem (E635000) and intermediates.

Synthesis

99-05-8

2-Thia-5-azabicyclo[2.2.1]heptane-5-carboxylic acid, 3-oxo-, (4-nitrophenyl)methyl ester, (1S,4S)-

151072-00-3

3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid

202467-69-4

At 60 °C, m-aminobenzoic acid (9.45 g, 68.9 mmol) was dissolved in 200 g of methanol and 1 g of tributylphosphine and 400 ml of a methanolic solution of 4M HCl were added. Subsequently, 220 g of methanol solution of 4-nitrobenzyl (1S,4S)-3-oxo-2-thia-5-azabicyclo[2.2.1]heptane-5-carboxylate (19.8 g, 64.28 mmol) was slowly added. The reaction was stirred at the same temperature for 3 hours. After completion of the reaction, the slurry was cooled and filtered to obtain white crystals. The white crystals were washed with methanol and then dried under vacuum to afford 3-((2S,4S)-4-mercapto-1-(((4-nitrobenzyloxy)oxy)carbonyl)pyrrolidine-2-carboxamido)benzoic acid (127.8 g) in 97% molar yield and 99.2% HPLC purity.

References

[1] Patent: CN105566193, 2016, A. Location in patent: Paragraph 0014; 0015
[2] Patent: CN104130262, 2017, B. Location in patent: Paragraph 0132; 0133; 0134

3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid synthesis

Synthesis of 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid from 3-Aminobenzoic acid and 2-Thia-5-azabicyclo[2.2.1]heptane-5-carboxylic acid, 3-oxo-, (4-nitrophenyl)methyl ester, (1S,4S)-

3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid Preparation Products And Raw materials

Raw materials

2-Thia-5-azabicyclo[2.2.1]heptane-5-carboxylic acid, 3-oxo-, (4-nitrophenyl)methyl ester, (1S,4S)- trans-4-Hydroxy-1-(4-nitrobenzyloxycarbonyl)-L-proline 4-Nitrobenzyl chloroformate 3-Aminobenzoic acid L-Hydroxyproline

Hydrochloric acid Methanol Tributylphosphine

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Preparation Products

3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid Suppliers

Global Suppliers ( 254)

Supplier	Tel	Email	Country	ProdList	Advantage
Hunan Kaimir Biotechnology Co., Ltd.	0731-+86-0731-89714511 +86-18602659358	sales@chemapi.com.cn	China	35	58
Zhengzhou Yuanli Biological Technology Co., Ltd.	0371-67897870 18339906974	2130541246@qq.com	China	111	58
Jiangxi ravel Biotechnology Co.,Ltd	18502728206	hj@ruiweier.cn	China	2436	58
Shanghai Boyle Chemical Co., Ltd.	021-50182298 021-50180596	sales@boylechem.com	China	2202	55
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Shanghai Buddy Bio-pharm Intermediates Ltd	021-50460499 13120992296	xinxiaojuan513@163.com	China	24	64
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59

Supplier	Advantage
Hunan Kaimir Biotechnology Co., Ltd.	58
Zhengzhou Yuanli Biological Technology Co., Ltd.	58
Jiangxi ravel Biotechnology Co.,Ltd	58
Shanghai Boyle Chemical Co., Ltd.	55
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Chembest Research Laboratories Limited	61
Shanghai Buddy Bio-pharm Intermediates Ltd	64
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59
Shanghai Longsheng chemical Co.,Ltd.	59

View Latest Price from 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid 202467-69-4	$5.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2025-06-27	Side Train of Ertapenem 202467-69-4		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2025-06-20	Side Train of Ertapenem 202467-69-4	$8.00-50.00	1kg	0.99	20 tons	Hebei Yanxi Chemical Co., Ltd.

3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid
202467-69-4
$5.00
99%
Henan Fengda Chemical Co., Ltd

Side Train of Ertapenem
202467-69-4
$0.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

Side Train of Ertapenem
202467-69-4
$8.00-50.00
0.99
Hebei Yanxi Chemical Co., Ltd.

202467-69-4 (3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid ) Related Search:

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3-([[(2S,4S)-4-Mercapto-1-((4-nitrobenzyloxy)carbonyl)pyrrolidin-2-yl]carbonyl]aMino)benzoic acid The Sidechain of Ertapenem 2-[(3-carboxyanilino)-oxomethyl]-4-mercapto-4-nitro-2-(phenylmethyl)-1-pyrrolidinecarboxylate Ertaipenem side chain Ertapenem side chain, Side chain for Ertapenem Ertapenem side chains [(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid Side Train of Ertapenem 3-[[[(2s,4s)-4-mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid 3-[[[(2S,4S)-4-MERCAPTO-2-PYRROLIDINYL-1-(4-NITROBENZYLOXY)CARBONYL]CARBONYL]AMINO]BENZOIC ACID (2S, 4S)-2-[[(3-carboxyphenyl)amino]carbonyl]-4-mercapto-1-(4-nitrobenzyl)pyrrolidinecarboxylate 4-NITROBENZYL-(2S, 4S)-2-[[(3-CARBOXYPHENYL)AMINO]CARBONYL]-4-MERCAPTO-1-PYRROLIDINECARBOXYLATE ERTAPENEM SIDE CHAIN, 3-[[[(2S,4S)-4-MERCAPTO-1-(4-NITROBENZYLOXY)CARBONYL-2-PYRROLIDINYL]CARBONYL]AMINO]BENZOIC ACID 3-[[[(2S, 4S)-4-MERCAPTO-1-TERT-BUTOXYCARBONYL-2-PYRROLIDINYL]CARBONYL]AMINO]BENZOIC ACID SIDECHAINIFORERTAPENEM 3-[[[(2S, 4S)-4-mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino] 2-[[(3-Carboxyphenyl)amino]carbonyl]-4-mercapto-1-pyrrolidinecarboxylic acid (2S-cis)-1-[(4-nitrophenyl)methyl] ester 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2- Side Chain of ErtapeneM Gibberellic Acid (GA4+7) Tech 3-((2S,4S)-4-Mercapto-1-(((4-nitrobenzyl)oxy)carbonyl)pyrrolidine-2-carboxaMido)benzoic acid E he pei south side chain 1-Pyrrolidinecarboxylic acid, 2-[[(3-carboxyphenyl)amino]carbonyl]-4-mercapto-, 1-[(4-nitrophenyl)methyl] ester, (2S,4S)- 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid USP/EP/BP 3-[[[(2S,4S)-4-MERCAPTO-2-PYRROLIDINYL-1-(4-NITROBENZYLOXY)C... PNB protected ertapenem side chain TIANFUCHEM--202467-69-4--High purity 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid factory price Benzoicacid,3-amino-9-iodo-,methylester 3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoicaci Etapec South Side Chain Ertapenem Side Chain Ⅰ, 98% Ertapenem side chain ERTAPENEM SIDE CHAIN 1 SIDE CHAIN FOR ERTAPENEM 202467-69-4 202467-71-9 202427-69-4 C20H19N3O7S