Boc-glycine tert-butyl ester
- CAS No.
- 111652-20-1
- Chemical Name:
- Boc-glycine tert-butyl ester
- Synonyms
- N-Boc-gL;BOC-GLY-OTBU;N-BOC-Gly-OtBu;Boc-Gly-Ot<;Boc-Gly-Otbu-OH;Boc-Gly-OtBu, ≥98%;Boc-Gly-OtBu;BOC-GLYCINE T-BUTYL ESTER;Boc-glycine tert-butyl ester;(Tert-Butoxy)Carbonyl Gly-OtBu
- CBNumber:
- CB2157582
- Molecular Formula:
- C11H21NO4
- Molecular Weight:
- 231.29
- MDL Number:
- MFCD00191866
- MOL File:
- 111652-20-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 66-68 °C(lit.) |
|---|---|
| Boiling point | 306.0±25.0 °C(Predicted) |
| Density | 1.023 |
| storage temp. | 2-8°C |
| solubility | very soluble in Methanol |
| pka | 11.06±0.46(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| Water Solubility | 1.05g/L at 20℃ |
| BRN | 5002580 |
| Major Application | peptide synthesis |
| InChI | 1S/C11H21NO4/c1-10(2,3)15-8(13)7-12-9(14)16-11(4,5)6/h7H2,1-6H3,(H,12,14) |
| InChIKey | ZDKFMHKWZATBMR-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)CNC(=O)OC(C)(C)C |
| LogP | 2.21 at 25℃ |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H401-H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312a-P330-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-51 | |||||||||
| Safety Statements | 20/21-29/56 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29241990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Boc-glycine tert-butyl ester price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 423297 | Boc-Gly-OtBu 99% | 111652-20-1 | 5g | $134 | 2023-06-20 | Buy |
| TCI Chemical | B4156 | N-(tert-Butoxycarbonyl)glycine tert-Butyl Ester >98.0%(HPLC)(N) | 111652-20-1 | 1g | $22 | 2026-04-30 | Buy |
| TCI Chemical | B4156 | N-(tert-Butoxycarbonyl)glycine tert-Butyl Ester >98.0%(HPLC)(N) | 111652-20-1 | 5g | $54 | 2026-04-30 | Buy |
| Usbiological | 265310 | Boc-glycine tert-butyl ester | 111652-20-1 | 1g | $358 | 2026-06-03 | Buy |
| Usbiological | 265310 | Boc-glycine tert-butyl ester | 111652-20-1 | 2g | $468 | 2026-06-03 | Buy |
Boc-glycine tert-butyl ester Chemical Properties, Uses, Production
Chemical Properties
Whtie powder
Uses
peptide synthesis
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
27532-96-3
111652-20-1
Example 1 (Example of reaction formula (1)) [13]: tert-butyl glycinate hydrochloride (10.0 g, 59.7 mmol) was suspended in toluene (46.2 ml), heated to 60 °C and then triethylamine (6.51 g, 64.3 mmol) was added, and the reaction was stirred for 0.5 hours. Subsequently, a solution of di-tert-butyl dicarbonate (10.0 g, 45.9 mmol) in toluene (11.6 ml) was added slowly and dropwise to the reaction mixture and the reaction was continued for 6 hours. After completion of the reaction, it was quenched by addition of water (30 ml) and the organic layer was separated. The organic layer was distilled by azeotropic distillation with n-hexane to remove the solvent to afford tert-butyl N-Boc-glycinate (10.6 g, 45.9 mmol, 100% yield). The structure of the product was confirmed by 1H-NMR analysis.
References
[1] Patent: CN103068795, 2016, B. Location in patent: Paragraph 0119; 0120; 0121; 0122; 0123; 0124
[2] Synthesis, 1987, # 3, p. 223 - 225
[3] The Journal of organic chemistry, 2002, vol. 67, # 24, p. 8291 - 8298
Boc-glycine tert-butyl ester Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Sichuan Tongsheng Amino acids Co.,Ltd. | 0838-2274206 17340404235 | sales@biots.cn | China | 300 | 66 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Chiral Chemicals Inc. | 021-37285021 13472570865 | tym7xi@aliyun.com | China | 299 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from Boc-glycine tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Boc-Gly-OtBU
111652-20-1
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2025-04-04 | Boc-Gly-OtBu
111652-20-1
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2021-07-13 | Boc-Gly-OtBu
111652-20-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Boc-Gly-OtBU
111652-20-1
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Boc-Gly-OtBu
111652-20-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Boc-Gly-OtBu
111652-20-1
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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