| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
- Boc-Gly-OtBU
-
-
2026-09-11
- CAS:111652-20-1
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
- Boc-Gly-OtBu
-
-
2025-04-04
- CAS:111652-20-1
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
- Boc-Gly-OtBu
-
- $15.00
-
2021-07-13
- CAS:111652-20-1
- Min. Order: 1KG
- Purity: 99%+ HPLC
|
| | Boc-glycine tert-butyl ester Basic information |
| Product Name: | Boc-glycine tert-butyl ester | | Synonyms: | Boc-Gly-OtBu;tert-Butyl 2-((tert-butoxycarbonyl)aMino)acetate;N-(tert-Butoxycarbonyl)glycine tert-butyl ester
(tert-Butoxycarbonylamino)acetic acid tert-butyl ester;tert-butyl 2-(tert-butoxycarbonyl)acetate;tert-butyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate;Boc-glycinetert-butyl ester≥ 98% (HPLC);N-Boc-glycine tert-butyl ester, 95%;(Tert-Butoxy)Carbonyl Gly-OtBu | | CAS: | 111652-20-1 | | MF: | C11H21NO4 | | MW: | 231.29 | | EINECS: | 696-236-2 | | Product Categories: | | | Mol File: | 111652-20-1.mol |  |
| | Boc-glycine tert-butyl ester Chemical Properties |
| Melting point | 66-68 °C(lit.) | | Boiling point | 306.0±25.0 °C(Predicted) | | density | 1.023 | | storage temp. | 2-8°C | | solubility | very soluble in Methanol | | pka | 11.06±0.46(Predicted) | | form | powder to crystal | | color | White to Almost white | | Water Solubility | 1.05g/L at 20℃ | | BRN | 5002580 | | Major Application | peptide synthesis | | InChI | 1S/C11H21NO4/c1-10(2,3)15-8(13)7-12-9(14)16-11(4,5)6/h7H2,1-6H3,(H,12,14) | | InChIKey | ZDKFMHKWZATBMR-UHFFFAOYSA-N | | SMILES | CC(C)(C)OC(=O)CNC(=O)OC(C)(C)C | | LogP | 2.21 at 25℃ |
| Hazard Codes | Xn | | Risk Statements | 22-51 | | Safety Statements | 20/21-29/56 | | WGK Germany | 3 | | HS Code | 29241990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | Boc-glycine tert-butyl ester Usage And Synthesis |
| Chemical Properties | Whtie powder | | Uses | peptide synthesis | | reaction suitability | reaction type: Boc solid-phase peptide synthesis | | Synthesis | Example 1 (Example of reaction formula (1)) [13]: tert-butyl glycinate hydrochloride (10.0 g, 59.7 mmol) was suspended in toluene (46.2 ml), heated to 60 °C and then triethylamine (6.51 g, 64.3 mmol) was added, and the reaction was stirred for 0.5 hours. Subsequently, a solution of di-tert-butyl dicarbonate (10.0 g, 45.9 mmol) in toluene (11.6 ml) was added slowly and dropwise to the reaction mixture and the reaction was continued for 6 hours. After completion of the reaction, it was quenched by addition of water (30 ml) and the organic layer was separated. The organic layer was distilled by azeotropic distillation with n-hexane to remove the solvent to afford tert-butyl N-Boc-glycinate (10.6 g, 45.9 mmol, 100% yield). The structure of the product was confirmed by 1H-NMR analysis. | | References | [1] Patent: CN103068795, 2016, B. Location in patent: Paragraph 0119; 0120; 0121; 0122; 0123; 0124
[2] Synthesis, 1987, # 3, p. 223 - 225
[3] The Journal of organic chemistry, 2002, vol. 67, # 24, p. 8291 - 8298 |
| | Boc-glycine tert-butyl ester Preparation Products And Raw materials |
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