BOC-Glycine
- CAS No.
- 4530-20-5
- Chemical Name:
- BOC-Glycine
- Synonyms
- BOC-GLY-OH;BOC-GLY;N-(TERT-BUTOXYCARBONYL)GLYCINE;N-BOC-GLYCINE;Boc-g;BOC-L-GLY-OH;BOC-GLYCINE-OH;Boc-glycin;TBOC-GLYCINE;GLYCINE-N-T-BOC
- CBNumber:
- CB8187260
- Molecular Formula:
- C7H13NO4
- Molecular Weight:
- 175.18
- MDL Number:
- MFCD00002690
- MOL File:
- 4530-20-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 86-89 °C(lit.) |
|---|---|
| Boiling point | 306.47°C (rough estimate) |
| Density | 1.2843 (rough estimate) |
| refractive index | 1.4353 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Powder |
| pka | 4.00±0.10(Predicted) |
| color | White to off-white |
| Water Solubility | soluble |
| BRN | 1101514 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C7H13NO4/c1-7(2,3)12-6(11)8-4-5(9)10/h4H2,1-3H3,(H,8,11)(H,9,10) |
| InChIKey | VRPJIFMKZZEXLR-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CNC(OC(C)(C)C)=O |
| CAS DataBase Reference | 4530-20-5(CAS DataBase Reference) |
| EPA Substance Registry System | Glycine, N-[(1,1-dimethylethoxy)carbonyl]- (4530-20-5) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H303-H318 | |||||||||
| Precautionary statements | P280i-P305+P351+P338-P310a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-41-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-39-36 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 29241990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
BOC-Glycine price More Price(123)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.53000 | Boc-Gly-OH Novabiochem? | 4530-20-5 | 25G | $65.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.53000 | Boc-Gly-OH Novabiochem? | 4530-20-5 | 100G | $135 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.53000 | Boc-Gly-OH Novabiochem® | 4530-20-5 | 1 kg | $916 | 2026-04-30 | Buy |
| Sigma-Aldrich | 15420 | Boc-Gly-OH ≥99.0% (T) | 4530-20-5 | 5g | $35.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 15420 | Boc-Gly-OH ≥99.0% (T) | 4530-20-5 | 25g | $132 | 2026-04-30 | Buy |
BOC-Glycine Chemical Properties, Uses, Production
Chemical Properties
White To Off-White Powder
Uses
BOC-Glycine is used in the composition of drugs containing Ketoprofen, and Sodium hyaluronate as antiinflammatory agents.
Uses
Boc-Gly-OH can be used:
- For the esterification reaction to synthesize N-Boc amino acid esters for peptide chemistry.
- For the synthesis of tripeptide H-Gly-Pro-Glu-OH, analogs of neuroprotective drugs.
- As a promoter for the allylation of hydrazones and isatin.
Synthesis Reference(s)
Tetrahedron Letters, 16, p. 4393, 1975 DOI: 10.1016/S0040-4039(00)91133-X
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
1. 18.1g L-glycine, 100ml water was added to the reaction flask and stirred. Add 16g of sodium hydroxide configured 0.01mol/L alkaline solution adjusted to alkaline. Then 8g of (Boc)2O was added and reacted for 2 hours, then 8g of (Boc)2O was added and reacted for 2 hours and finally 9g of (Boc)2O was added and reacted for 4 hours.
2. The impurities were extracted three times with hexane 12 ml/time. 3 mol/L hydrochloric acid was used to adjust the PH=3 and then the product was extracted three times with dioxane 0.6 L/time. Combine the ester layers and wash with brine to neutral. Add 15 g of anhydrous sodium sulfate to dry for 10 hours.
3. Filter, concentrate the filtrate dry under reduced pressure, add 60 ml of hexane and stir to crystallize. Centrifuged out the product and dried. Obtained product 25.0 g. Yield 93.87%.
BOC-Glycine Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Dexinjia Biopharm Co., Ltd., | 0531-82375887 18245291386 | 3955164757@qq.com | China | 47 | 58 |
| GenChem & GenPharm (Changzhou) Co., Ltd. | 0519-85720003 18861157602 | 410649415@qq.com | China | 111 | 58 |
| Hubei Hengluyuan Technology Co., Ltd. | 027-027-88188016 18062414339 | 1764683941@qq.com | China | 479 | 58 |
| Shanghai Chiral Chemicals Inc. | 021-37285021 13472570865 | tym7xi@aliyun.com | China | 299 | 64 |
| Jinan Dexinjia Bio&Tech Co., Ltd | 0531-82375880 15098789112 | 3845379039@qq.com | China | 1457 | 58 |
| Organic Bio-Tech (Suzhou) Co.,Ltd | 18061997750 | info@organic-Biotechnology.com | China | 192 | 58 |
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 423 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
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View Latest Price from BOC-Glycine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Boc-gly
4530-20-5
|
1kg | 98+ | 1T | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2026-06-30 | BOC-Glycine
4530-20-5
|
1KG | 99.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | BOC-Glycine
4530-20-5
|
$9.00 | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Boc-gly
4530-20-5
- 98+
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- BOC-Glycine
4530-20-5
- 99.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- BOC-Glycine
4530-20-5
- $9.00
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
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