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Vatalanib base

Vatalanib base Structure
Vatalanib base structure
CAS No.
212141-54-3
Chemical Name:
Vatalanib base
Synonyms
VATALANIB;VataL;PTK787 2HCl;Vatalanib HCl;Vatalanib 2HCL;VATALANIB BASE;PTK787 free base;PTK/ZK free base;Vatalanib (PTK787);anib (PTK787) 2HCL
CBNumber:
CB2173616
Molecular Formula:
C20H15ClN4
Molecular Weight:
346.81
MDL Number:
MFCD08458963
MOL File:
212141-54-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Vatalanib base Properties

Melting point 209-212°
Boiling point 587.8±50.0 °C(Predicted)
Density 1.330±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility ≥16.85 mg/mL in DMSO; ≥3.0125 mg/mL in EtOH with gentle warming and ultrasonic; ≥32.53 mg/mL in H2O with gentle warming and ultrasonic
form solid
pka 5.46±0.10(Predicted)
color Light yellow to yellow
EWG's Food Scores 1
NCI Dictionary of Cancer Terms vatalanib
FDA UNII 5DX9U76296
NCI Drug Dictionary vatalanib

SAFETY

Risk and Safety Statements

HS Code  2933399990

Vatalanib base price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth MIA14154 Vatalanib 212141-54-3 100mg $342 2026-06-04 Buy
Biosynth MIA14154 Vatalanib 212141-54-3 1g $1073.8 2026-06-04 Buy
ChemScene CS-5248 Vatalanib 99.93% 212141-54-3 5mg $54 2026-06-04 Buy
ChemScene CS-5248 Vatalanib 99.93% 212141-54-3 10mg $87 2026-06-04 Buy
ChemScene CS-5248 Vatalanib 99.93% 212141-54-3 25mg $157 2026-06-04 Buy
Product number Packaging Price Buy
MIA14154 100mg $342 Buy
MIA14154 1g $1073.8 Buy
CS-5248 5mg $54 Buy
CS-5248 10mg $87 Buy
CS-5248 25mg $157 Buy

Vatalanib base Chemical Properties, Uses, Production

Uses

Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.

Uses

anti-viral

Definition

ChEBI: A member of the class of phthalazines that is phthalazine in which the hydrogens at positions 1 and 4have been replaced by a p-chlorophenylamino group and a pyridin-4-ylmethyl group, respectively. It is a multi-targeted tyrosine kinase inhibit r for all isoforms of VEGFR, PDGFR and c-Kit.

in vivo

Vatalanib induces dose-dependent inhibition of the angiogenic response to VEGF and PDGF in both a growth factor implant model and a tumor cell-driven angiogenesis model after once-daily oral dosing (25-100 mg/kg). In the same dose range, Vatalanib also inhibits the growth and metastasesof several human carcinomas in nude mice without significant effect on circulating blood cells or bone marrow leukocytes[1].

IC 50

VEGFR2: 37 nM (IC50)

Vatalanib base synthesis

87-41-2
212141-54-3
Synthesis of Vatalanib base from Phthalide

Vatalanib base Preparation Products And Raw materials

Raw materials

Pyridine, 4-(bromomethyl)- (9CI) 4-(Chloromethyl)pyridine 1-Chloro-4-(4-pyridinylmethyl)phthalazine 4-(4-Pyridylmethyl)-1(2H)-phtalazinone 3-Hydroxy-2-pyridin-4-yl-inden-1-one
Phthalide 1-Chloro-4-iodobenzene 4-Chlorobenzenamine hydrochloride Phthalonitrile 4-Chloroaniline
4-Bromochlorobenzene

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Preparation Products

Vatalanib base Suppliers

Global Suppliers ( 135)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2110 70
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Tianjin YongSheng Biotechnology Co., Ltd. 022-60987737 13512258274;13820956092 sales@immortalbio.com China 154 55
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
China Kouting Group Limited +86 (21) 5811-6473 5811-6475 sales@koutingchina.com China 494 60
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61
LGM Pharma 70
Chemsky (shanghai) International Co.,Ltd 60
Jinan Trio PharmaTech Co., Ltd. 62
Dalian Meilun Biotech Co., Ltd. 58
Tianjin YongSheng Biotechnology Co., Ltd. 55
NCE Biomedical Co.,Ltd. 55
China Kouting Group Limited 60
Guangzhou Isun Pharmaceutical Co., Ltd 55

View Latest Price from Vatalanib base manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vatalanib base pictures 2026-09-17 Vatalanib base
212141-54-3
 $10.00 1ASSAYS 99% 1 ton RongNa Biotechnology Co.,Ltd
Vatalanib free base pictures 2026-08-15 Vatalanib free base
212141-54-3
 $40.00-118.00 99.52% 10g TargetMol Chemicals Inc.
Vatalanib base pictures 2019-12-24 Vatalanib base
212141-54-3
 $1.00 100g 98%min Career Henan Chemical Co

Vatalanib base Spectrum

Vatalanib base(212141-54-3)1HNMR

212141-54-3 (Vatalanib base) Related Search:

Chlorodimethylphenylsilane Trimethylphenylammonium chloride 4-Methylpyridine 2,6-Lutidine 2-Chloro-5-chloromethylpyridine
Triethanolamine Dibenzylamine Bis(2-ethylhexyl)amine 2,4,6-Collidine Triallylamine
Azamethiphos Vatalanib Dihydrochloride 4-Methoxy-pyridine-2-carboxylic acid amide 4-(4-Aminophenoxy)pyridine Sorafenib
4-(4-Aminophenoxy)-N-methylpicolinamide Vatalanib base

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N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)- 1-Phthalazinamine 1-PhthalazinaMine, N-(4-chlorophenyl)-4-(4-pyridinylMethyl)- Vatalanib (PTK787) Dihydrochloride Base Pynasunate, ZK222584, CGP-79787, PTK 787 (4-Chloro-phenyl)-(4-pyridin-4-ylmethyl-phthalazin-1-yl)-amine Vatalanib free base (PTK787 free base PTK787 free base PTK787 FREE BASE; PTK/ZK FREE BASE; CGP-79787 FREE BASE; ZK-222584 FREE BASE CGP-79787 free base PTK/ZK free base ZK-222584 free base) PTK787 2HCl ZK 222584 (CPG-79787) 2HCL;PTK787 2HCL Vatalanib (free base) SORAFENIB BASE VATALANIB Vatalanib 2HCL VATALANIB BASE Vatalanib (PTK787) anib (PTK787) 2HCL VataL Vatalanib free bas Vatalanib HCl Vatalanib free base (PTK-787 VATALANIB 212141-54-3 Antineoplastic