TOLRESTAT
- CAS No.
- 82964-04-3
- Chemical Name:
- TOLRESTAT
- Synonyms
- CS-148;Lorestat;AY-27773;Alredase;Aldredase;TOLRESTAT;Tolrestatin;Tolrestat, AY 27773;TOLRESTAT USP/EP/BP;TOLRESTAT(FORR&DONLY)
- CBNumber:
- CB2174693
- Molecular Formula:
- C16H14F3NO3S
- Molecular Weight:
- 357.35
- MDL Number:
- MFCD00864170
- MOL File:
- 82964-04-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Tolrestat ≥98% (HPLC) | SML1573 | 5MG | $113 |
| Tolrestat ≥98% (HPLC) | SML1573 | 25MG | $459 |
| Tolrestat ≥98% | 29693 | 1mg | $36 |
| Tolrestat ≥98% | 29693 | 5mg | $128 |
| Tolrestat ≥98% | 29693 | 10mg | $236 |
| More product size | |||
| Melting point | 164-165° |
|---|---|
| Boiling point | 498.1±55.0 °C(Predicted) |
| Density | 1.399±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) |
| form | powder |
| pka | 3.49±0.10(Predicted) |
| color | white to beige |
| InChI | 1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22) |
| InChIKey | LUBHDINQXIHVLS-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1c2c(c(ccc2)C(=S)N(CC(=O)O)C)ccc1OC |
| CAS DataBase Reference | 82964-04-3 |
| FDA UNII | 0T93LG5NMK |
| ATC code | A10XA01 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
TOLRESTAT price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1573 | Tolrestat ≥98% (HPLC) | 82964-04-3 | 5MG | $113 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1573 | Tolrestat ≥98% (HPLC) | 82964-04-3 | 25MG | $459 | 2026-04-30 | Buy |
| Cayman Chemical | 29693 | Tolrestat ≥98% | 82964-04-3 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 29693 | Tolrestat ≥98% | 82964-04-3 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 29693 | Tolrestat ≥98% | 82964-04-3 | 10mg | $236 | 2026-04-30 | Buy |
TOLRESTAT Chemical Properties,Uses,Production
Description
Tolrestat is a long-acting aldose reductase inhibitor reportedly useful in the prophylaxis of diabetic neuropathy, retinopathy and cataracts.
Description
Tolrestat is an aldose reductase inhibitor (IC50 = 35 nM for the bovine lens enzyme). Dietary administration of tolrestat decreases sciatic nerve galactitol accumulation in a rat model of galactosemia (ED50 = 7.3 mg/kg per day) and sciatic nerve sorbitol accumulation (ED50 = 4.8 mg/kg per day) in a rat model of diabetes induced by streptozotocin (STZ; ). It also decreases urinary total protein exretion in a rat model of STZ-induced diabetes when administered at a dose of 25 mg/kg per day. Topical administration of tolrestat (2 and 3% in 10 μl four times per day) decreases levels of galactitol in the lens of and inhibits cataract formation in rats fed a high-galactose diet.
Chemical Properties
Crystallized, melting point 164-165℃. Tolrestat Methyl Ester: C17H16F3NO3S. melting point 109-110℃.
Originator
American Home Products (USA)
Uses
Tolrestat is an aldose reductase inhibitor.
Uses
Alredase (Wyeth-Ayerst).
Definition
ChEBI: Tolrestat is a member of naphthalenes. It has a role as an EC 1.1.1.21 (aldehyde reductase) inhibitor.
brand name
Alredase
Biochem/physiol Actions
Tolrestat is considered to be effective in treating the consequences of diabetes including neuropathy, nephropathy, retinopathy and esophageal motility and vibration perception. Tolrestat is also believed to have lesser or no toxic effects.
References
[1] KAZIMIR SESTANJ. N-[[5-(Trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor[J]. Journal of Medicinal Chemistry, 1984, 27 3: 255-256. DOI: 10.1021/jm00369a003
[2] M L MCCALEB. Intervention with the aldose reductase inhibitor, tolrestat, in renal and retinal lesions of streptozotocin-diabetic rats.[J]. Diabetologia, 1991, 34 10: 695-701. DOI: 10.1007/bf00401513
[3] STEFANIA BANDITELLI . A New Approach Against Sugar Cataract Through Aldose Reductase Inhibitors[J]. Experimental eye research, 1999, 69 5: Pages 533-538. DOI: 10.1006/exer.1999.0729
TOLRESTAT Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9984 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +86-18627785180 | info@finetechnology-ind.com | China | 9539 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9932 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501 | product@acmec-e.com | China | 33301 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
