ChemicalBook >> CAS DataBase List >>DMT-2′O-Methyl-rC(ac) Phosphoramidite

DMT-2′O-Methyl-rC(ac) Phosphoramidite

DMT-2′O-Methyl-rC(ac) Phosphoramidite structure

CAS No.: 199593-09-4

Chemical Name:: DMT-2′O-Methyl-rC(ac) Phosphoramidite

Synonyms: DMT-2'-O-Me-C(Ac)-CE Phosphoramidite;DMT-2'O-METHYL-RC(AC) PHOSPHORAMIDITE;(2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite;Cytidine Impurity 14;2’-OMe -dC(Ac) Amidite;N4-Ac-5'-O-DMT-2'-OMe-C-CE;2'-OMe-Ac-C Phosphoramidite;2'-OMe-N-Ac CytidineAmidite;Ac-2'-Ome-rC Phosphoramidite;2'-OMe-Ac-C Phosphoramidite

CBNumber:: CB21871625

Molecular Formula:: C42H52N5O9P

Molecular Weight:: 801.86

MDL Number:: MFCD12912403

MOL File:: 199593-09-4.mol

MSDS File:: SDS

Last updated:2026-05-28 00:00:14

Request For Quotation

DMT-2′O-Methyl-rC(ac) Phosphoramidite Properties

Melting point	102 - 104°C
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	powder
pka	10.18±0.20(Predicted)
color	white to off-white
biological source	non-animal source (no BSE/TSE risk)
InChIKey	WNWUMIPFLOKTEZ-UAQIPLLRSA-N
SMILES	O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(C)=O)=NC2=O)[C@H](OC)[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N \|&1:25,27,39,42,r\|
UNSPSC Code	41116105
NACRES	NA.51

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Safety Statements	24/25
WGK Germany	3
HS Code	29349990
Storage Class	11 - Combustible Solids

DMT-2′O-Methyl-rC(ac) Phosphoramidite price More Price(68)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C213140	DMT-2′O-Methyl-rC(ac) Phosphoramidite configured for MerMade	199593-09-4	1 g	$111	2026-04-30	Buy
Sigma-Aldrich	C213180	DMT-2′O-Methyl-rC(ac) Phosphoramidite configured for PerkinElmer, configured for Polygen	199593-09-4	1G	$138	2026-04-30	Buy
Sigma-Aldrich	C213140	DMT-2′O-Methyl-rC(ac) Phosphoramidite configured for MerMade	199593-09-4	5 g	$139	2026-04-30	Buy
Sigma-Aldrich	C213140	DMT-2′O-Methyl-rC(ac) Phosphoramidite configured for MerMade	199593-09-4	10 g	$317	2026-04-30	Buy
Sigma-Aldrich	C213100	DMT-2′O-Methyl-rC(ac) Phosphoramidite ≥99% (31P-NMR)	199593-09-4	100g	$7180	2026-04-30	Buy

Product number	Packaging	Price	Buy
C213140	1 g	$111	Buy
C213180	1G	$138	Buy
C213140	5 g	$139	Buy
C213140	10 g	$317	Buy
C213100	100g	$7180	Buy

DMT-2′O-Methyl-rC(ac) Phosphoramidite Chemical Properties, Uses, Production

Uses

2''-OMe-Ac-C Phosphoramidite (CAS# 199593-09-4) is a nucleotide used in the solid-phase synthesis of phosphorothioate oligonucleotides using sulfurization byproducts for in situ capping.

Application

2′O-Methyl RNA nucleoside including DMT-2′O-Methyl-rC(ac) Phosphoramidite can be advantageously incorporated in nucleic acid probes with RNA or DNA for in-vivo or in-vitro applications to convey nuclease resistance.The unique combination of properties of 2′O-Methyl RNA had found widespread use in the fields of:
Diagnostic probes
Aptamer and ribozyme development
Mixed 2′O-Methyl-RNA/DNA antisense molecules

General Description

DMT-2′O-Methyl-rC(ac) Phosphoramidite is one of the 2′O-Methyl RNA monomers that feature methoxy groups at the 2′-position. Themethoxy groups are perfectly stable in all conditions employed in theassembly of oligonucleotides by automated phosphoramidite synthesis, andin all standard alkaline deprotection conditions.Its key features include:
High yield of crude oligonucleotides
Compatible with DNA synthesis
Can be employed together with DNA or RNA phosphoramidites in thesame synthesis to produce mixmer oligonucleotides
Recommended deprotection conditions are 8 hours at 55 °C usingconcentrated ammonia solution, or with AMA (concentrated ammonia/40% aqueous methylamine I/I, v/v) for 10 minutes at 65 °C
Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as nospecial precautions are required to provide protection against nucleolyticdegradation
Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6minutes compared to 90 seconds for DNA monomers)
2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry

DMT-2′O-Methyl-rC(ac) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

DMT-2′O-Methyl-rC(ac) Phosphoramidite Suppliers

Global Suppliers ( 193)

Supplier	Tel	Email	Country	ProdList	Advantage
Nugene Biopharm Science (Hangzhou) Co., Ltd.	13326014885	service@nugene.com.cn	China	56	58
Hefei Shitong Biotechnology Co., Ltd.	15555170917	sales@stongbio.com	China	515	58
Wuhu Huaren Science and Technology Co., Ltd.	5842013 18155347026	xujuan@hdpharm.com	China	255	64
Tianjin Orilife Biopharma Co.,Ltd.	18522633659 17602299400	fengyiran@cnorilife.com	China	188	58
Hubei wei shi reagent group ltd., company	17771898297 13125137661	2853877621@qq.com	China	7992	58
Wuhan Tangzhi Pharmaceutical Co., Ltd.	027-63498076 13658392159	sale@glycogene.com	China	838	58
Hongene Biotech Corporation	021-64757213	info@hongene.com	China	672	61
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16306	64

Supplier	Advantage
Nugene Biopharm Science (Hangzhou) Co., Ltd.	58
Hefei Shitong Biotechnology Co., Ltd.	58
Wuhu Huaren Science and Technology Co., Ltd.	64
Tianjin Orilife Biopharma Co.,Ltd.	58
Hubei wei shi reagent group ltd., company	58
Wuhan Tangzhi Pharmaceutical Co., Ltd.	58
Hongene Biotech Corporation	61
Energy Chemical	61
Adamas Reagent, Ltd.	59
Nanjing Chemlin Chemical Co., Ltd	64

View Latest Price from DMT-2′O-Methyl-rC(ac) Phosphoramidite manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 199593-09-4		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-08-08	N4-Ac-5'-O-DMT-2'-OMe-C-CE 199593-09-4		100mg	≥98%	20tons	Hefei Huana Biomedical Technology Co.,Ltd.
2023-03-22	2'-OMe-Ac-C CE Phosphoramidite 199593-09-4	$100.00		99%	5tons	SHANGHAI NOVRIBO BIOTECH

N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
199593-09-4
98%
Henan Aochuang Chemical Co.,Ltd.

N4-Ac-5'-O-DMT-2'-OMe-C-CE
199593-09-4
$0.00
≥98%
Hefei Huana Biomedical Technology Co.,Ltd.

2'-OMe-Ac-C CE Phosphoramidite
199593-09-4
$100.00
99%
SHANGHAI NOVRIBO BIOTECH

199593-09-4 (DMT-2′O-Methyl-rC(ac) Phosphoramidite) Related Search:

5'-O-[(N,N-Diisopropylamino)-(2-cyanoethoxy)phosphinyl]-3'-O-(4,4'-dimethoxytrityl)-thymidine N-Acetyl-L-tyrosine ethyl ester DMT-2′O-TBDMS-rU Phosphoramidite DMT-2'O-Methyl-rU Phosphoramidite Dmt-2'-f-dc(ac) amidite

N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-6'-O-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite DMT-2'O-TBDMS-rA(bz) Phosphoramidite Ac-rC Phosphoramidite 2’-O-Methyl-rA(N-Bz)phosphoramidite DMT-dG(dmf) Phosphoramidite

2'-OMe-ibu-G Phosphoramidite Acetyl coenzyme A sodium salt Acetylacetone Acetylferrocene tributyl acetocitrate

Cytidine DMT-2′O-Methyl-rC(ac) Phosphoramidite Acetyl-resveratrol

1of4

2'-OMe-Ac-C Phosphoramidite 2’-O-Methyl-rC(N-Ac)Phosphoramidite 5'-O-DMT-2'-O-Me-rC(N-Ac)-3'-CEDPA N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-methoxytetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite 5'-DMT-2'-OMe-rC(N-Ac) Phosphoramidite N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite DMT-2′O-Methyl-rC(ac) Phosphoramidite 2'-O-Methyl-N4-Acetyl-5'-O-DMT-Cytidine-3'-CE-Phosphoramidite -5-(4-Acetamido-2-oxopyrimidin-1(2H) Ac-2'-Ome-rC Phosphoramidite 2'-OMe-Ac-rC -CE Phosphoramidite N4-acetyl-5'-O-(4, 4'-Dimethoxytrityl)-2'-O-methyl-Cytidine-3'-CE-Phosphoramidite 2'-OMe-Ac-C Phosphoramidite (~90%) Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] 2'-OMe-C(Ac) Phosphoramidite N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite USP/EP/BP 5'-Dimethoxytrityl-N-acetyl-Cytidine,2'-O-methyl,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite N4-ACETYL-5-O-DMTr-2-O-METHYLCYTIDINE-3-O- CE-AMIDITE 5'-O-DMT-2'-OMe-Ac-C-CE-Phosphoramidite Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] 5'-O-DMT-N4-Acetyl-2'-O-methylcytidine 3'-CE phosphoramidite 5'-O-DMT-2'-OMe-Acetyl-Cytidine-CE Phosphoramidite DMT-2-O-ME-C-CE Phosphoramidite "DMT-2'-O-Me-dC(Ac) Phosphoramidite" N4-Ac-5'-O-DMT-2'-OMe-C-CE DMT-2’-OMe-C(Ac)-CE Phosphoramidite 2'-OMe-N-Ac Cytidine?Amidite DMTr-2'-O-Me-rC(Ac)-3'-CE-Phosphoramidite 2’-OMe -dC(Ac) Amidite 5'-ODMT-2'-OMe-N-Ac Cytidine-3'-OCEPA 2'-OMe-Ac-C Phosphoramidite 2'-OMe-C(Ac)-CE-Phosphoramidite 2'-OMe-Ac-C CE Phosphoramidite 2'-OMe-rC(Ac)Phosphoramidite 2'-OMe-N-Ac CytidineAmidite Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite Cytidine Impurity 14 Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester N4-Acetyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite N4-Ac-5'-O-DMT-2'-OMe-C-CE, 99%, ≤0.2%(K.F.) DMT-2'-0Me-C(Ac)-CE-Phosphoramidite N4-Acetyl-5' -O-DMT-2' -O-methylcytidine-3' -O-[O-(2-cya noethyl)-N, N'-di isopropylphos phoramidite, Me-rC Ac, Phosphoramidite, 2’-OMe-rC(N-Ac) CE Phosphoramidite 2’-OMe-rC(N-Ac) phosphoramidite DMT-2’-OMe-Ac-C CE Phosphoramidite 2'-OMe-C(Ac/Bz)-3'-CE-phosphoramidite 2'-0-MOE-5-Me-C(Bz)-3'-CE-phosphoramidite DMT-2'-O-Me-C(Ac)-CE Phosphoramidite DMT-2'O-METHYL-RC(AC) PHOSPHORAMIDITE 199593-09-4 C42H52N5O9P Amidite