1-Benzylpyrrolidin-3-yl-methanol
- CAS No.
- 5731-17-9
- Chemical Name:
- 1-Benzylpyrrolidin-3-yl-methanol
- Synonyms
- CHEMBRDG-BB 4003810;1-BENZYL-DL-BETA-PROLINOL;1-Benzylpyrrolidine-3-methanol;1-Benzyl-3-pyrrolidinemethanol;1-BENZYL-3-PYRROLIDIN-3-YLMETHANOL;1-BENZYL-3-HYDROXYMETHYLPYRROLIDINE;1-Benzyl-1H-pyrrolidin-3-yl-Methanol;(1-Benzyl-1H-pyrrolidin-3-yl)Methanol;3-HYDROXYMETHYL-N-BENZYL- PYRROLIDINE;1-(Phenylmethyl)-3-pyrrolidinemethanol
- CBNumber:
- CB2194664
- Molecular Formula:
- C12H17NO
- Molecular Weight:
- 191.27
- MDL Number:
- MFCD04038527
- MOL File:
- 5731-17-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 129 °C(Press: 0.9 Torr) |
|---|---|
| Density | 1.082±0.06 g/cm3(Predicted) |
| storage temp. | Store at room temperature |
| form | solid |
| pka | 14.93±0.10(Predicted) |
| Appearance | Light yellow to yellow Viscous liquid |
| InChI | InChI=1S/C12H17NO/c14-10-12-6-7-13(9-12)8-11-4-2-1-3-5-11/h1-5,12,14H,6-10H2 |
| InChIKey | QPQQBJDSKDWQMJ-UHFFFAOYSA-N |
| SMILES | N1(CC2=CC=CC=C2)CCC(CO)C1 |
| CAS DataBase Reference | 5731-17-9(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P310 |
| Hazard Codes | Xi,T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
1-Benzylpyrrolidin-3-yl-methanol price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000012 | 1-Benzylpyrrolidin-3-yl-methanol Aldrich | 5731-17-9 | 1g | $191 | 2026-04-30 | Buy |
| Usbiological | 265702 | 1-Benzylpyrrolidin-3-yl-methanol Asreported | 5731-17-9 | 500mg | $333 | 2026-06-03 | Buy |
| Usbiological | 265702 | 1-Benzylpyrrolidin-3-yl-methanol Asreported | 5731-17-9 | 1g | $536 | 2026-06-03 | Buy |
| Usbiological | 265702 | 1-Benzylpyrrolidin-3-yl-methanol Asreported | 5731-17-9 | 2g | $738 | 2026-06-03 | Buy |
| Usbiological | 265702 | 1-Benzylpyrrolidin-3-yl-methanol Asreported | 5731-17-9 | 5g | $1276 | 2026-06-03 | Buy |
1-Benzylpyrrolidin-3-yl-methanol Chemical Properties, Uses, Production
Synthesis
51535-00-3
5731-17-9
Example A: Synthesis of N-benzyl-3-hydroxymethylpyrrolidine Step a: Reduction of methyl 1-benzyl-5-oxopyrrolidine-3-carboxylate to 1-benzyl-3-hydroxymethylpyrrolidine Under an inert atmosphere, methyl 1-benzyl-5-oxopyrrolidine-3-carboxylate (1.0 equiv, commercially available) was dissolved in toluene and the mixture was cooled to 0 °C. To the cooled mixture was slowly added a dimethyl sulfide solution of borane-dimethyl sulfide complex (3.75 equiv.). The reaction mixture was heated to 100°C-110°C and refluxed for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature, further cooled to -5 °C to -10 °C, and then sodium bicarbonate solution was added dropwise. The mixture was slowly warmed to room temperature and then refluxed for 2 hours. After the reaction mixture was cooled, the organic layer was separated and the aqueous layer was extracted with toluene. The combined toluene layers were washed sequentially with water and brine. Finally, the organic solvent was removed by evaporation under reduced pressure to afford the target product N-benzyl-3-hydroxymethylpyrrolidine in 99.14% yield.
References
[1] Patent: WO2006/18708, 2006, A2. Location in patent: Page/Page column 21-22
[2] Letters in Organic Chemistry, 2011, vol. 8, # 3, p. 155 - 162
[3] Patent: US2004/147502, 2004, A1. Location in patent: Page/Page column 36-37
[4] Organic Letters, 1999, vol. 1, # 5, p. 799 - 801
[5] Patent: US2005/165005, 2005, A1. Location in patent: Page/Page column 59-60
1-Benzylpyrrolidin-3-yl-methanol Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Dexinjia Biopharm Co., Ltd | 0531-82375893 15553111391 | phoebe@jndxj.com | China | 285 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. | 21-54820552 17702105771 | 188738128@qq.com | China | 300 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Beijing HengPuGao Pharmaceutical Chemistry Technology Co., Ltd. | 010-81520996 13439320863 | hengpugao@126.com | China | 159 | 57 |
View Latest Price from 1-Benzylpyrrolidin-3-yl-methanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 1-BENZYLPYRROLIDIN-3-YL-METHANOL
5731-17-9
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co | |
 |
2019-07-06 | 1-BENZYLPYRROLIDIN-3-YL-METHANOL
5731-17-9
|
$1.00 | 1kg | 95%-99% | 100kg | Career Henan Chemical Co |
-
- 1-BENZYLPYRROLIDIN-3-YL-METHANOL
5731-17-9
- $1.00
- 98%
- Career Henan Chemical Co
-
- 1-BENZYLPYRROLIDIN-3-YL-METHANOL
5731-17-9
- $1.00
- 95%-99%
- Career Henan Chemical Co
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