1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid
- CAS No.
- 5733-86-8
- Chemical Name:
- 1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid
- Synonyms
- AKOS BB-9373;AURORA 17719;BUTTPARK 17\07-15;IFLAB-BB F1799-0573;TIMTEC-BB SBB011410;OTAVA-BB BB7018611176;1-Benzyl-5-oxopyrrolidine...;1-Benzyl-4-carboxy-2-pyrrolidone;1-Benzyl-4-carboxy-2-pyrrolidinone;1-benzyl-5-oxy-3-pyrolidinemacetic acid
- CBNumber:
- CB3726244
- Molecular Formula:
- C12H13NO3
- Molecular Weight:
- 219.24
- MDL Number:
- MFCD00085749
- MOL File:
- 5733-86-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 142.0 to 146.0 °C |
|---|---|
| Boiling point | 471.3±45.0 °C(Predicted) |
| Density | 1.314±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 4.51±0.20(Predicted) |
| color | White to Almost white |
| CAS DataBase Reference | 5733-86-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331-H320 |
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405 |
| Hazard Codes | Xi |
| RTECS | UY0686500 |
| HazardClass | IRRITANT |
| HS Code | 2933790090 |
1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4264 | 1-Benzyl-5-oxopyrrolidine-3-carboxylic Acid >98.0%(GC)(T) | 5733-86-8 | 1g | $159 | 2022-04-27 | Buy |
| Apolloscientific | OR6330 | 1-Benzyl-5-oxopyrrolidine-3-carboxylic acid 97% | 5733-86-8 | 5g | $79 | 2026-06-04 | Buy |
| Apolloscientific | OR6330 | 1-Benzyl-5-oxopyrrolidine-3-carboxylic acid 97% | 5733-86-8 | 25g | $256 | 2026-06-04 | Buy |
| Chem-Impex | 43852 | 1-Benzyl-5-oxopyrrolidine-3-carboxylic acid ≥98%(GC) | 5733-86-8 | 1G | $205.41 | 2026-05-19 | Buy |
| Matrix Scientific | 008263 | 1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid | 5733-86-8 | 1.00g | $24 | 2026-05-18 | Buy |
1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid Chemical Properties, Uses, Production
Synthesis
51535-00-3
5733-86-8
Methyl 1-benzyl-5-oxo-3-pyrrolidinecarboxylate (2.00 g, 8.57 mmol) was used as a raw material and dissolved in a mixed solvent of methanol (10 mL) and tetrahydrofuran (10 mL). Subsequently, 2 N aqueous lithium hydroxide (8.6 mL) was added to this solution. The reaction mixture was heated to reflux for 20 minutes. Upon completion of the reaction, the reaction solution was cooled in an ice bath, adjusted to acidity with aqueous potassium bisulfate, and then extracted with ethyl acetate. The organic layers were combined, concentrated and purified by repurification (ethyl acetate/hexane) and dried to give 1-benzyl-5-oxo-3-pyrrolidinecarboxylic acid (1.83 g, 97% yield).1H-NMR (DMSO-d6) δ: 2.56 (2H, m), 3.80 (1H, m), 3.15 (2H, m), 3.25 (2H, m), 4.36 (2H , q, J = 8.6 Hz), 7.27 (5H, m), 12.61 (1H, s).
References
[1] Patent: EP1403255, 2004, A1. Location in patent: Page 78
[2] Journal of Medicinal Chemistry, 1997, vol. 40, # 15, p. 2374 - 2385
[3] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 377 - 379
[4] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
[5] Patent: WO2006/123725, 2006, A1. Location in patent: Page/Page column 64-65
1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Weizongchen Pharmaceutical Service (Shanghai) Limited | 021 6089 3288 18163855446 | co@viva-supply.com | China | 35 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 | |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai G&K Biomedical Scientific Inc. | 021-34502253 13391330186 | info@gksci.com | China | 133 | 52 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| skychemical Co.Ltd | 021-20958197 20965099 | sales@skychemical.com | China | 1182 | 57 |
| Shanghai Litong Chemical Technology Co.,Ltd. | 13598610367 0373-7129549 | 2468833170@qq.com | China | 932 | 58 |
View Latest Price from 1-Benzyl-5-oxo-pyrrolidine-3-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-03-06 | 4-(2-METHYL-IMIDAZOL-1-YL)-BENZALDEHYDE
5733-86-8
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 4-(2-METHYL-IMIDAZOL-1-YL)-BENZALDEHYDE
5733-86-8
- $1.00
- 99%
- Career Henan Chemical Co
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