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1-Fluoro-4-(1-methylethenyl)benzene

1-Fluoro-4-(1-methylethenyl)benzene Structure
1-Fluoro-4-(1-methylethenyl)benzene structure
CAS No.
350-40-3
Chemical Name:
1-Fluoro-4-(1-methylethenyl)benzene
Synonyms
4-Fluoro-α4-fluoro-methylstyrene;Fluoroalphamethylstyrene;4-FLUORO-A-METHYLSTYRENE;4-fluoro-à-methylstyrene;-oxo-benzeneacetaldehyde;4-Fluoro-α-methylstyrene;p-Fluoro-α-methylstyrene;2-(4-FLUOROPHENYL)PROPENE;P-Fluoro-alfa-methylstyrene
CBNumber:
CB2198778
Molecular Formula:
C9H9F
Molecular Weight:
136.17
MDL Number:
MFCD00042297
MOL File:
350-40-3.mol
MSDS File:
SDS
Last updated:2025-09-25 17:15:13
Product description Number Pack Size Price
4-Fluoro-α-methylstyrene AldrichCPR CDS001211 500 mg $73.1
4-Fluoro-alpha-methylstyrene (stabilized with TBC) >98.0%(GC) F0250 5mL $86
4-Fluoro-alpha-methylstyrene (stabilized with TBC) >98.0%(GC) F0250 25mL $249
4-Fluoro-α- 012307 1mg $425
4-Fluoro-α-methylstyrene F594000 10g $130
More product size
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1-Fluoro-4-(1-methylethenyl)benzene Properties

Boiling point 183°C
Density 1.01 g/mL at 20 °C(lit.)
refractive index 1.5085-1.5125
Flash point 53 °C
storage temp. Sealed in dry,2-8°C
solubility soluble in Methanol
form clear liquid
color colorless to yellow/brown
BRN 2039696
CAS DataBase Reference 350-40-3(CAS DataBase Reference)
FDA UNII 8TQ5TT8QWC
NIST Chemistry Reference 4-FC6H4C(CH3)=CH2(350-40-3)
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H315-H319-H335
Precautionary statements  P210-P233-P240-P241+P242+P243-P280-P303+P361+P353-P370+P378-P403+P235-P501-P261-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  10
Safety Statements  16
RIDADR  UN 1993 3/PG 3
WGK Germany  3
Hazard Note  Irritant/Keep Cold
HazardClass  3
PackingGroup  III
HS Code  2942000090
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
1 0

1-Fluoro-4-(1-methylethenyl)benzene price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich CDS001211 4-Fluoro-α-methylstyrene AldrichCPR 350-40-3 500 mg $73.1 2025-07-31 Buy
TCI Chemical F0250 4-Fluoro-alpha-methylstyrene (stabilized with TBC) >98.0%(GC) 350-40-3 5mL $86 2025-07-31 Buy
TCI Chemical F0250 4-Fluoro-alpha-methylstyrene (stabilized with TBC) >98.0%(GC) 350-40-3 25mL $249 2025-07-31 Buy
Usbiological 012307 4-Fluoro-α- 350-40-3 1mg $425 2021-12-16 Buy
TRC F594000 4-Fluoro-α-methylstyrene 350-40-3 10g $130 2021-12-16 Buy
Product number Packaging Price Buy
CDS001211 500 mg $73.1 Buy
F0250 5mL $86 Buy
F0250 25mL $249 Buy
012307 1mg $425 Buy
F594000 10g $130 Buy

1-Fluoro-4-(1-methylethenyl)benzene Chemical Properties,Uses,Production

Chemical Properties

clear colorless to yellowish liquid

Uses

4-Fluoro-a-methylstyrene is used in the synthesis of Paroxetine (P205750), which is a selective serotonin reuptake inhibitor. Used as an antidepressant.

Synthesis

Methyltriphenylphosphonium bromide

1779-49-3

4-Fluoroacetophenone

403-42-9

1-Fluoro-4-(1-methylethenyl)benzene

350-40-3

GENERAL METHOD: Potassium tert-butoxide (t-BuOK, 2.47 g, 22.00 mmol) was added to an anhydrous tetrahydrofuran (THF, 70 mL) solution of methyltriphenylphosphonium bromide (7.12 g, 20.00 mmol) in four batches at 0 °C. The reaction mixture was stirred at 0 °C for 2 h, followed by slow dropwise addition of anhydrous THF (20 mL) solution of 4-fluoroacetophenone (20 mmol) over 30 min. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride (NH4Cl, 50 mL) solution. The reaction solution was extracted three times with petroleum ether (3 x 50 mL). All organic phases were combined, washed with saturated saline (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated. Finally, the residue was purified by fast column chromatography using petroleum ether (Pet) as eluent to afford the target product 1-fluoro-4-(prop-1-en-2-yl)benzene.

References

[1] Tetrahedron, 2008, vol. 64, # 37, p. 8610 - 8617
[2] Organic Letters, 2018, vol. 20, # 18, p. 5747 - 5751
[3] Angewandte Chemie - International Edition, 2013, vol. 52, # 32, p. 8450 - 8453
[4] Angew. Chem., 2013, vol. 125, # 32, p. 8608 - 8611,4
[5] Tetrahedron, 2017, vol. 73, # 49, p. 6901 - 6905

1-Fluoro-4-(1-methylethenyl)benzene synthesis

403-42-9
350-40-3
Synthesis of 1-Fluoro-4-(1-methylethenyl)benzene from 4-Fluoroacetophenone

1-Fluoro-4-(1-methylethenyl)benzene Preparation Products And Raw materials

Raw materials

2-(4-FLUOROPHENYL)-2-PROPANOL METHYLTRIPHENYLPHOSPHONIUM IODIDE 1-Chloro-4-fluorobenzene Isopropenyl acetate 4-Fluoroacetophenone
4-Fluorobenzoyl chloride 4-FLUOROPHENYLMAGNESIUM BROMIDE Methyltriphenylphosphonium iodide Acetone 4-Fluorobenzonitrile

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Preparation Products

m,alpha-dimethylstyrene 1,4-DIISOPROPENYLBENZENE

1-Fluoro-4-(1-methylethenyl)benzene Suppliers

Global( 138)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 3999 58
Changzhou Ditong Chemical Co.,Ltd 		+86-0519-88299272 info@edengenechem.com China 2176 58
BTC Nantong Pharmaceuticals Technology Co.,Ltd 		+8618068193575 sales4@btcpharm.com China 251 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49976 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15093 58
Wuhan Fortuna Chemical Co., Ltd 		+86-027-59207850 +86-13986145403; info@fortunachem.com China 6000 58
CD Chemical Group Limited 		+8615986615575 info@codchem.com China 20342 58
changzhou huayang technology co., ltd 		+8615250961469 2571773637@qq.com China 9644 58
BTC pharm India 		+918790379245 banny.janga@btcpharm.com India 1262 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Changzhou Ditong Chemical Co.,Ltd 		58
BTC Nantong Pharmaceuticals Technology Co.,Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
AFINE CHEMICALS LIMITED 		58
Wuhan Fortuna Chemical Co., Ltd 		58
CD Chemical Group Limited 		58
changzhou huayang technology co., ltd 		58
BTC pharm India 		58

View Lastest Price from 1-Fluoro-4-(1-methylethenyl)benzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Fluoro-4-(1-methylethenyl)benzene pictures 2025-12-17 1-Fluoro-4-(1-methylethenyl)benzene
350-40-3
 US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
1-Fluoro-4-(1-methylethenyl)benzene pictures 2024-05-30 1-Fluoro-4-(1-methylethenyl)benzene
350-40-3
 US $1.00 / KG 1KG 99% 20t Shaanxi Dideu Medichem Co. Ltd
1-Fluoro-4-(1-methylethenyl)benzene pictures 2024-02-26 1-Fluoro-4-(1-methylethenyl)benzene
350-40-3
 US $0.00-0.00 / kg 1kg 98% Kgs BTC Nantong Pharmaceuticals Technology Co.,Ltd

1-Fluoro-4-(1-methylethenyl)benzene Spectrum

1-Fluoro-4-(1-methylethenyl)benzene(350-40-3)1HNMR

350-40-3(1-Fluoro-4-(1-methylethenyl)benzene)Related Search:

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Xylene Trifluoropropene 3-(Trifluoromethyl)benzaldehyde Perfluoroethylene propylene copolymer POLY(ALPHA-METHYLSTYRENE)
Benzene Fluorine 4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE

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2-(4-FLUOROPHENYL)-1-PROPENE 2-(4-FLUOROPHENYL)PROPENE 1-FLUORO-4-(1-METHYLETHENYL)BENZENE 1-Fluoro-4-isopropenylbenzene 4-fluoro-methylstyrene 4-FLUORO-ALPHA-METHYLSTYRENE 4-FLUORO-A-METHYLSTYRENE Benzene, 1-fluoro-4-(1-methylethenyl)- p-Fluoro-alpha-methylstyrene Styrene, p-fluoro-alpha-methyl- Fluoroalphamethylstyrene P-Fluoro-alfa-methylstyrene 2-(4-Fluorophenyl)prop-1-ene 4-fluoro-à-methylstyrene 4-Fluoro-alpha-methylstyrene 97% 4-Fluoro-alpha-methylstyrene97% 4-Fluoro-ɑ-methylstyrene, 95% 4-Fluoro-alpha-methylstyrene (stabilized with TBC) 1-Fluoro-4-prop-1-en-2-ylbenzene 1-Isopropenyl-4-fluorobenzene 2-(p-Fluorophenyl)-1-propene 4-Fluoro-alpha-methylstyrene,95% 4-Fluoro-α-methylstyrene (stabilized with TBC) 4-Fluoro-&alpha 1-Fluoro-4-(prop-1-en-2-yl) -oxo-benzeneacetaldehyde 1-Fluoro-4-(1-propen-2-yl)benzene 4-Fluoro-α-methylstyrene(stabilizedwithTBC)> 2-(4-Fluorophenyl)-1-propene (stabilized with TBC) 4-Fluoro-α-methylstyrene p-Fluoro-α-methylstyrene 4-Fluoro-α-methylstyrene (stabilized with TBC) 350-40-3 C9H9F Analytical Standards Analytical Chromatography Product Catalog FA - FL Alphabetic