TYRPHOSTIN B7
- CAS No.
- 134036-53-6
- Chemical Name:
- TYRPHOSTIN B7
- Synonyms
- AG 370;TYRPHOSTIN B7;TYRPHOSTIN AG 370;TYROPHOSTIN AG 370;AG-370, PDGFR tyrosine kinase inhibitor;2-AMINO-4-(1H-INDOL-5-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE;2-AMINO-4-(1H-INDO-5'-YL)-1,1,3-TRICYANOBUTA-1,3-DIENE;3-AMINO-4-(1H-INDOL-5-YLMETHYLENE)-2-PENTENETRICARBONITRILE;2-Pentenetricarbonitrile, 3-amino-4-(1H-indol-5-ylmethylene)-;2-Amino-4-(1H-indo-5μ-yl)-1,1,3-tricyanobuta-1,3-diene, Tyrphostin B7
- CBNumber:
- CB2288901
- Molecular Formula:
- C15H9N5
- Molecular Weight:
- 259.27
- MDL Number:
- MFCD00236449
- MOL File:
- 134036-53-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
TYRPHOSTIN B7 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10010568 | AG-370 ≥95%(cis/transmixture) | 134036-53-6 | 1mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 10010568 | AG-370 ≥95%(cis/transmixture) | 134036-53-6 | 5mg | $274 | 2026-04-30 | Buy |
| Cayman Chemical | 10010568 | AG-370 ≥95%(cis/transmixture) | 134036-53-6 | 10mg | $481 | 2026-04-30 | Buy |
| Cayman Chemical | 10010568 | AG-370 ≥95%(cis/transmixture) | 134036-53-6 | 25mg | $1053 | 2026-04-30 | Buy |
| ChemScene | CS-0064001 | AG 370 97.0% | 134036-53-6 | 1mg | $143 | 2026-06-04 | Buy |
TYRPHOSTIN B7 Chemical Properties,Uses,Production
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors such as epidermal growth factor (EGF) or platelet-
Uses
AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor[1].
Definition
ChEBI: AG-370 is a member of indoles.
in vitro
previous study found that ag-370 inhibited pdgf receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates that coprecipitated with the pdgf receptor in digitonin-permeabilized fibroblasts and in intact fibroblasts. when compared with ag18, a potent egf receptor blocker, ag370 was more efficient in inhibiting pdgf-induced proliferation of fibroblasts and phosphorylation of the intracellular protein substrates. under the conditions in which ag370 could inhibit pdgf-induced mitogenesis and phosphorylation, ag18 did not alter [125i]pdgf internalization and enhance [125i]pdgf binding. these findings suggested that ag370 might have a therapeutic potential for treatment of diseases involving abnormal cellular proliferation induced by pdgf [1].
IC 50
20 μm for pdgf receptor kinase in human bone marrow fibroblasts
References
[1] bryckaert, m. c.,eldor, a.,fontenay, m., et al. inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. experimental cell research 199, 255-261 (1992).
TYRPHOSTIN B7 Preparation Products And Raw materials
Raw materials
Preparation Products
TYRPHOSTIN B7 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
134036-53-6(TYRPHOSTIN B7)Related Search:
1of4
