Boc-D-Lys(Z)-OH
- CAS No.
- 55878-47-2
- Chemical Name:
- Boc-D-Lys(Z)-OH
- Synonyms
- N6-((Benzyloxy)carbonyl)-N2-(tert-butoxycarbonyl)-D-lysine;NSC 334941;BOC-D-LYSINE(CBZ);BOC-D-LYSINE(Z)-OH;Nα-Boc-Nε-Z-D-lysine;N2-Boc-N6-Cbz-D-lysine;BOC-N-EPSILON-Z-D-LYSINE;Nalpha-Boc-Nepsilon-Z-D-lysine;Nα-Boc-Nε-Z-D-lysine≥ 98% (HPLC);(Tert-Butoxy)Carbonyl D-Lys(Z)-OH
- CBNumber:
- CB2295150
- Molecular Formula:
- C19H28N2O6
- Molecular Weight:
- 380.44
- MDL Number:
- MFCD00038262
- MOL File:
- 55878-47-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 587.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.176±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| pka | 3.99±0.21(Predicted) |
| Appearance | White to off-white Solid |
| optical activity | Consistent with structure |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Boc-D-Lys(Z)-OH price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 264801 | N-alpha-Boc-Nε-Z-D-lysine Asreported | 55878-47-2 | 5g | $373 | 2026-06-03 | Buy |
| Usbiological | 264801 | N-alpha-Boc-Nε-Z-D-lysine Asreported | 55878-47-2 | 10g | $519 | 2026-06-03 | Buy |
| Usbiological | 264801 | N-alpha-Boc-Nε-Z-D-lysine Asreported | 55878-47-2 | 25g | $844 | 2026-06-03 | Buy |
| Usbiological | 264801 | N-alpha-Boc-Nε-Z-D-lysine Asreported | 55878-47-2 | 50g | $1187 | 2026-06-03 | Buy |
| Usbiological | 264801 | N-alpha-Boc-Nε-Z-D-lysine Asreported | 55878-47-2 | 100g | $1693 | 2026-06-03 | Buy |
Boc-D-Lys(Z)-OH Chemical Properties, Uses, Production
Chemical Properties
White powder
Synthesis
106719-44-2
501-53-1
55878-47-2
General procedure for the synthesis of (R)-6-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)hexanoic acid from N-(tert-butoxycarbonyl)-D-lysine and benzyl chloroformate: to an aqueous solution of 1 M NaOH (37 mL), N-(tert-butoxycarbonyl)-D-lysine (3.00 g, 12.2 mmol) was added at room temperature, then slowly dioxane was added until the suspension was completely dissolved. Subsequently, benzyl chloroformate (2.70 g, 15.9 mmol) was added dropwise over 30 min at 0 °C. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the dioxane was removed by distillation under reduced pressure. The reaction mixture was acidified to pH 2 with 1 M HCl at 0 °C. The aqueous layer was extracted with EtOAc and the combined organic layers were dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford the target compound 29 (4.4 g, 11.6 mmol, 95% yield) as a white foamy solid, which did not require further purification. 1H-NMR (360 MHz, CDCl3): δ (ppm) 7.37-7.23 (m, 5H), 6.18 (br s, 1H), 5.17-4.86 (m, 3H), 4.83 (s, 1H), 4.22-4.04 (m, 1H), 3.13-3.11 (m, 2H), 1.76-1.37 (m, 15H ). 13C-NMR (150 MHz, CDCl3): δ (ppm) 176.4 (CO), 156.8 (CO), 156.0 (CO), 136.6 (Cq), 128.7 (2 × CH), 128.3 (2 × CH), 128.1 (CH), 80.4 (Cq), 66.9 (CH2), 53.3 (CH). 40.7 (CH2), 32.0 (CH2), 29.3 (CH2), 29.5 (3×CH3), 22.1 (CH2). MS (ESI) m/z (%): (C14H20N2O4) 222 (14), (C7H12NO4) 174 (12), 128 (32), 108 (27), 92 (11), (C7H7) 91 (100), 84 (20), 57 (52), 41 (20). MS (ESI) m/z calculated value C14H20N2O4 [M+H-C5H9O2]+, 280.14; measured value, 280.14. LC-MS (ESI) m/z calculated value C19H28N2O6Na [M+Na]+, 403.2; measured value, 403.7. HPLC purity, 96%, tR = 19.7min, Gradient A.
References
[1] Journal of Medicinal Chemistry, 2016, vol. 59, # 5, p. 2222 - 2243
[2] Patent: WO2017/63910, 2017, A1. Location in patent: Page/Page column 38-39
Boc-D-Lys(Z)-OH Preparation Products And Raw materials
Raw materials
Preparation Products
Boc-D-Lys(Z)-OH Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Tianjin Chempharmatech Co.,Ltd. | 022-66211079 13212288319 | sales@chempharmatech.com | China | 943 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| NINGBO INNO PHARMCHEM CO.,LTD. | 86-574-27787657 | info@dearchem.com | China | 4607 | 58 |
| Shanghai GL Peptide Ltd. | +86-21-61263310 13764994101 | fisherwang@glschina.com | China | 8059 | 55 |
| Wuxi Asia Peptide Biotechnology Limited Company | 0510-83583050 13771062561 | willsun@peptide-search.com | China | 6713 | 58 |
View Latest Price from Boc-D-Lys(Z)-OH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-18 | BOC-D-LYS(Z)-OH
55878-47-2
|
$7.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- BOC-D-LYS(Z)-OH
55878-47-2
- $7.00
- 99%
- Career Henan Chemical Co
