ChemicalBook >> CAS DataBase List >>4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester

4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester

4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester structure

CAS No.: 496786-98-2

Chemical Name:: 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester

Synonyms: tert-butyl 4-[5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate;tert-butyl 4-[5-(4;4-(5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOR;6- -4-Boc-1-piperazine and) pyridine-3-borate;6-(4-Boc-piperazin-1-yl)pyridine-3-boronic acid;2-[4-(N-BOC)Piperazin-1-yl]pyridine-5-boronic acid;2-(4-BOC-PIPERAZINE)PYRIDINE-5-BORONIC ACID PINACOL ESTER;2-(4-BOC-Piperazino)pyridine-5-boronic acid,pinacol ester;6-(4-BOC-1-PIPERAZINO)PYRIDINE-3-BORONIC ACID PINACOL ESTER;2-(4-Boc-1-piperazinyl)pyridine-5-boronic acid pinacol ester

CBNumber:: CB2296324

Molecular Formula:: C20H32BN3O4

Molecular Weight:: 389.3

MDL Number:: MFCD04039875

MOL File:: 496786-98-2.mol

MSDS File:: SDS

Last updated:2026-09-12 18:50:37

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4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester Properties

Melting point	165-169 °C
Boiling point	515.9±50.0 °C(Predicted)
Density	1.14±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	solid
pka	8.41±0.31(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C20H32BN3O4/c1-18(2,3)26-17(25)24-12-10-23(11-13-24)16-9-8-15(14-22-16)21-27-19(4,5)20(6,7)28-21/h8-9,14H,10-13H2,1-7H3
InChIKey	JWUBVPJWWYYRLJ-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCN(C2=NC=C(B3OC(C)(C)C(C)(C)O3)C=C2)CC1
CAS DataBase Reference	496786-98-2(CAS DataBase Reference)
UNSPSC Code	12352103
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Safety Statements

22-24/25

WGK Germany

HazardClass

IRRITANT

HS Code

2933998090

Storage Class

11 - Combustible Solids

NFPA 704

	0
2		0

4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	654337	6-(4-Boc-piperazin-1-yl)pyridine-3-boronic acid pinacol ester 96%	496786-98-2	5g	$410	2026-04-30	Buy
Sigma-Aldrich	654337	6-(4-Boc-piperazin-1-yl)pyridine-3-boronic acid pinacol ester 96%	496786-98-2	1g	$174	2023-06-20	Buy
Apolloscientific	OR9766	6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]pyridine-3-boronic acid, pinacol ester >97%	496786-98-2	1g	$21	2026-06-04	Buy
Apolloscientific	OR9766	6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]pyridine-3-boronic acid, pinacol ester >97%	496786-98-2	5g	$40	2026-06-04	Buy
Apolloscientific	OR9766	6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]pyridine-3-boronic acid, pinacol ester >97%	496786-98-2	25g	$169	2026-06-04	Buy

Product number	Packaging	Price	Buy
654337	5g	$410	Buy
654337	1g	$174	Buy
OR9766	1g	$21	Buy
OR9766	5g	$40	Buy
OR9766	25g	$169	Buy

4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester Chemical Properties, Uses, Production

Uses

6-(4-Boc-piperazin-1-yl)pyridine-3-boronic Acid Pinacol Ester is used as a reactant in the preparation of fluorogenic probes used to distinguish chemical warfare agents and their mimics.

Synthesis

73183-34-3

153747-97-8

4-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDIN-2-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

496786-98-2

Under nitrogen protection, 4-Boc-1-(5-bromo-2-pyridyl)piperazine (125 g, 366 mmol) was dissolved in DMF (1.30 L), and bipinacolate pinacol ester (186 g, 732 mmol), palladium acetate (4.09 g, 18.3 mmol), triphenylphosphine (19.2 g, 73.2 mmol) and potassium acetate ( 108 g, 1.10 mol). The reaction mixture was stirred at 80 °C overnight. After completion of the reaction, it was cooled to room temperature and the solid was collected by filtration. The filtrate was concentrated under reduced pressure and the resulting residue was purified by silica gel fast column chromatography (eluent: ethyl acetate/petroleum ether, 1:50 v/v) to afford the target product tert-butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)piperidin-2-yl]piperazine-1-carboxylate (90c) as a white solid (80.0 g, yield 56%). Mass spectrum (LCMS, ESI positive ion mode): calculated value C20H32BN3O4 [M+H]+ 390.2, measured value 390.2.

References

[1] Patent: US2014/364414, 2014, A1. Location in patent: Paragraph 0945; 0950-0951
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 11, p. 5361 - 5379
[3] Patent: US2013/225548, 2013, A1. Location in patent: Paragraph 0531; 0632
[4] Patent: CN104650049, 2018, B. Location in patent: Paragraph 0426; 0427

4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Bis(pinacolato)diboron 4-Boc-1-(5-bromo-2-pyridyl)piperazine Triphenylphosphine Potassium Acetate N,N-Dimethylformamide

Palladium (II) Acetate

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Preparation Products

6-(4-N-Boc-piperazine-1-yl)-3-pyridinyl boronic acid tert-Butyl 4-(5-hydroxypyridin-2-yl)piperazine-1-carboxylate

4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester Suppliers

Global Suppliers ( 144)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Chem-Milestone Co., Ltd	021-50273253 13641951838	chemmilestone@163.com	China	149	62
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shanghai Cuisen Pharmaceutical Technology Co., Ltd.	13472757003	yongnan.wang@cendrix.cn	China	971	65

Supplier	Advantage
Shanghai Chem-Milestone Co., Ltd	62
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Pure Chemistry Scientific Inc.	62
Shanghai Longsheng chemical Co.,Ltd.	59
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Shanghai Cuisen Pharmaceutical Technology Co., Ltd.	65

View Latest Price from 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-15	2-(4-boc-piperazino)pyridine-5-boronic acid pinacol ester 496786-98-2		1KG	98%	20Tons	Shaanxi Dideu New Materials Co. Ltd

2-(4-boc-piperazino)pyridine-5-boronic acid pinacol ester
496786-98-2
98%
Shaanxi Dideu New Materials Co. Ltd

4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester Spectrum

4-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDIN-2-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(496786-98-2)¹HNMR

496786-98-2 (4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester) Related Search:

tert-Butyl N-methyl-N-[3-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridin-2-yl]carbamate 2-(Cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carboxylic acid diethylamide 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-(Dimethylamino)pyridine-5-boronic acid hydrate

4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester 3-Pyridylboronic acid 1-Methyl-5-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine 2-(4-Ethoxycarbonylpiperazine)pyridine-5-boronic acid pinacol ester 2-Aminopyridine-5-boronic acid, pinacol ester

4-[3-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester 6-(4-N-Boc-piperazine-1-yl)-3-pyridinyl boronic acid [6-(4-Methylpiperazin-1-yl)pyridin-3-yl]boronic acid 2-(4-Boc-piperazin-1-yl)-3-methylpyridine-5-boronic acid pinacol ester 1-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine

(6-Aminopyridin-3-yl)boronic acid 4-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester 2-(4-Boc-piperazin-1-yl)-4-methylpyridine-5-boronic acid pinacol ester

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TERT-BUTYL 4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2-PYRIDINYL]TETRAHYDRO-1(2H)-PYRAZINECARBOXYLATE TERT-BUTYL 4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-2-YL]PIPERAZINE-1-CARBOXYLATE 4-(5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-2-YL)-1-BOC-PIPERAZINE 2-(4-BOC-PIPERAZINE)PYRIDINE-5-BORONIC ACID PINACOL ESTER 2-(4-BOC-PIPERAZIN-1-YL)PYRIDINE-5-BORONIC ACID PINACOL ESTER 2-(4-TERT-BUTOXYCARBONYLPIPERAZIN-1-YL)PYRIDINE-5-BORONIC ACID, PINACOL ESTER 6-(4-Boc-piperazin-1-yl)pyridine-3-boronic acid pinacol ester, 96% 4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]piperazine-1-carboxylic acid tert-butyl ester 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl-piperazine-1-carboxylic acid tert-butyl ester tert-Butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate 97% 2-[4-(N-BOC)Piperazin-1-yl]pyridine-5-boronic acid 2-(4-Boc-1-piperazinyl)pyridine-5-boronic acid pinacol ester tert-Butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate, 2-[4-(tert-Butoxycarbonyl)piperazin-1-yl]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 6-(4-Boc-piperazin-1-yl)pyridine-3-boronic acid pinacol ester 96% tert-butyl 3-(5-(hydroxy((3-hydroxy-2,3-dimethylbutan-2-yl)oxy)boryl)pyridin-2-yl)piperazine-1-carboxylate 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl-piperazine-1-carboxylic acid tert-butyl est 6-(4-TERT-BUTOXYCARBONYLPIPERAZINYL)PYRIDINE-3-BORONIC ACID, PINACOL ESTER 6-(4-BOC-1-PIPERAZINO)PYRIDINE-3-BORONIC ACID PINACOL ESTER 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl-piperazine-1-carboxylic acid t tert-Butyl 4-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylüpiperazine-1-carboxylate tert-Butyl 4-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylüpiperazine-1-carboxylate 2-[4-(N-Boc)piperazin-1-yl]pyridine-5-boronic acid pinacol ester 6-(4-Boc-1-piperazinyl)pyridine-3-boronic acid pinacol ester 6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]pyridine-3-boronic acid pinacol ester 2-(4-BOC-Piperazino)pyridine-5-boronic acid,pinacol ester 4 2-(4-(N-Boc)piperazin-1-yl)pyridine-5-boronic acid pinacol ester 2-dioxaborolan-2-yl)-2-pyridinyl]tetrahydro-1(2H)-pyrazinecarboxylate tert-butyl 4-[5-(4 1-Piperazinecarboxylic acid, 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-, 1,1-dimethylethyl ester 6-[4-(tert-Butoxycarbonyl)piperazin-1-yl]pyridine-3-boronic acid, pinacol ester 97% t-Butyl 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate 4-(5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOR 6-(4-Boc-piperazin-1-yl)pyridine-3-boronic acid 6-(4-N-Boc-piperazin-1-yl)pyridine-3-boronic acid pinacol ester 1-Boc-4-[5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine 2-(4-tert-Butoxycarbonylpiperazin-1-yl)pyridine-5-boronic acid 4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine-1-carboxylate tert-Butyl 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridin-2-yl)piperazin-1-carboxylate 6- -4-Boc-1-piperazine and) pyridine-3-borate 2-(4-Boc-piperazino)pyridine-5-boronic acid pinacol ester - [P10620] tert-butyl 4-[5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate 4-[5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester 496786-98-2 C20H32BN3O4 C20H31BN3O4 Boronate Esters Boronic Acids and Derivatives Organometallic Reagents Heteroaryl Heterocyclic Compounds Boronic ester Organoborons Pyridine