(S)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
- CAS No.
- 199174-24-8
- Chemical Name:
- (S)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester
- Synonyms
- (S)-3-HydroxyMethyl-pyrrolidine-1-carboxylic;N-Boc-L-^b-Prolinol;N-Boc-L-beta-prolinol;N-Boc-L-^b-prolinol, 97+%;(S)-1-Boc-3-(hydroxyMethy...;(S)-1-Boc-3-pyrrolidinemethanol;(S)-N-BOC-PYRROLIDINE-3-METHANOL;(S)-1-Boc-3-hydroxymethylpyrrolidine;(S)-1-BO-C-3-hydroxymethylpyrolidine;1-Boc-3(S)-(HydroxyMethyl)Pyrrolidine
- CBNumber:
- CB2299789
- Molecular Formula:
- C10H19NO3
- Molecular Weight:
- 201.26
- MDL Number:
- MFCD03094726
- MOL File:
- 199174-24-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 285-289℃ |
|---|---|
| Density | 1.084 |
| storage temp. | 2-8°C |
| form | liquid |
| pka | 14.93±0.10(Predicted) |
| color | Brown |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-5-4-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m0/s1 |
| InChIKey | HKIGXXRMJFUUKV-QMMMGPOBSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CC[C@H](CO)C1 |
| CAS DataBase Reference | 199174-24-8 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
(S)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 55692 | (S)-1-BOC-3-HYDROXYMETHYL-PYRROLIDINE 97% | 199174-24-8 | 1G | $30 | 2026-04-30 | Buy |
| AstaTech | 55692 | (S)-1-BOC-3-HYDROXYMETHYL-PYRROLIDINE 97% | 199174-24-8 | 5G | $100 | 2026-04-30 | Buy |
| AstaTech | 55692 | (S)-1-BOC-3-HYDROXYMETHYL-PYRROLIDINE 97% | 199174-24-8 | 25G | $308 | 2026-04-30 | Buy |
| Apolloscientific | OR61431 | (3S)-3-(Hydroxymethyl)pyrrolidine, N-BOC protected >96% | 199174-24-8 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR61431 | (3S)-3-(Hydroxymethyl)pyrrolidine, N-BOC protected >96% | 199174-24-8 | 5g | $60 | 2026-06-04 | Buy |
(S)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Chemical Properties, Uses, Production
Uses
It is used as a pharmaceutical intermediate.
Synthesis
24424-99-5
![Pyrrolidine, 3-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-[(1R)-1-phenylethyl]-, (3S)-](/CAS/20210305/GIF/1264942-79-1.gif)
1264942-79-1
199174-24-8
The general procedure for the synthesis of (S)-1-BOC-3-hydroxymethylpyrrolidine from di-tert-butyl dicarbonate and compound (CAS:1264942-79-1) was as follows: 1. 1-[(1S)-1'-phenylethyl]pyrrolidine (8.81 g, 27.6 mmol) was dissolved in 1,2-dichloroethane (75 ml) at room temperature and 1-chloroethyl chloroformate (8.1 ml, 75 mmol) was added to this solution. 2. The resulting mixture was refluxed for 5 hours and then cooled to room temperature. 3. diisopropylethylamine (2.3 ml, 13 mmol) was added to the cooled brown solution and the mixture was refluxed again for 3 hours. 4. After completion of the reaction, the mixture was concentrated and the residue was diluted with ethyl acetate and washed with 1N aqueous hydrochloric acid. 5. The organic layer was dried with anhydrous sodium sulfate and subsequently concentrated under reduced pressure. 6. The residue was dissolved in methanol, an aqueous 1N hydrochloric acid solution was added and the aqueous solution was washed with ethyl acetate. 7. The aqueous solution was alkalized with solid potassium carbonate and the alkaline solution was cooled to 0 °C. 8. tert-Butyl dicarbonate (6.3 g, 29 mmol) was added to tetrahydrofuran (75 ml) at 0 °C. 9. The resulting mixture was stirred for 3 hours and then the organic material was extracted with ethyl acetate. 10. The organic layer was dried with anhydrous sodium sulfate and the solvent was removed under reduced pressure. 11. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 3/1 to 1/2) to afford tert-butyl 3-hydroxymethylpyrrolidine-1-carboxylate (2.96 g, 14.7 mmol, 53%) as a colorless oil.
References
[1] Patent: WO2011/19090, 2011, A1. Location in patent: Page/Page column 45-46
(S)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 19138996873 | 670603485@qq.com | China | 196 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from (S)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-09-05 | (S)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
199174-24-8
|
$1.80-3.60 | 1KG | 99% | 88KG | Career Henan Chemical Co |
-
- (S)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
199174-24-8
- $1.80-3.60
- 99%
- Career Henan Chemical Co
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