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Boc-D-prolinol

Boc-D-prolinol Structure
Boc-D-prolinol structure
CAS No.
83435-58-9
Chemical Name:
Boc-D-prolinol
Synonyms
tert-butyl (R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate;)-pyrroL;BOC-D-PRO-OL;BOC-D-PROLINOL;Boc-D-Proninol;N-BOC-D-PROLINOL;idine-1-carboxyL;1-BOC-D-PROLINOL;N-T-BOC-D-PROLINOL;N-benzyl-D-prolino
CBNumber:
CB5265945
Molecular Formula:
C10H19NO3
Molecular Weight:
201.26
MDL Number:
MFCD00040580
MOL File:
83435-58-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:36:20
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Boc-D-prolinol Properties

Melting point 60-64 °C (lit.)
alpha 49 º (589nm, =1.3, CHCl3)
Boiling point 289.5±13.0 °C(Predicted)
Density 1.084±0.06 g/cm3(Predicted)
refractive index 54 ° (C=5, MeOH)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka 14.77±0.10(Predicted)
form Crystalline Powder
color White to light beige
optical activity [α]23/D +50°, c = 1.3 in chloroform
Water Solubility insoluble
Major Application peptide synthesis
InChI InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(11)7-12/h8,12H,4-7H2,1-3H3/t8-/m1/s1
InChIKey BFFLLBPMZCIGRM-MRVPVSSYSA-N
SMILES N1(C(OC(C)(C)C)=O)CCC[C@@H]1CO
CAS DataBase Reference 83435-58-9(CAS DataBase Reference)
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36
WGK Germany  3
HS Code  29051990
Storage Class 11 - Combustible Solids
NFPA 704
1
2 0

Boc-D-prolinol price More Price(88)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 469440 (R)-(+)-1-Boc-2-pyrrolidinemethanol 98% 83435-58-9 1g $25 2023-01-07 Buy
TCI Chemical B3076 N-(tert-Butoxycarbonyl)-D-prolinol >98.0%(GC) 83435-58-9 1g $19 2026-04-30 Buy
TCI Chemical B3076 N-(tert-Butoxycarbonyl)-D-prolinol >98.0%(GC) 83435-58-9 5g $53 2026-04-30 Buy
Usbiological 261909 (R)-tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate Asreported 83435-58-9 1g $375 2026-06-03 Buy
Usbiological 261909 (R)-tert-Butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate Asreported 83435-58-9 2g $512 2026-06-03 Buy
Product number Packaging Price Buy
469440 1g $25 Buy
B3076 1g $19 Buy
B3076 5g $53 Buy
261909 1g $375 Buy
261909 2g $512 Buy

Boc-D-prolinol Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

N-(tert-Butoxycarbonyl)-D-prolinol is used to prepare (azetidinyl)methoxy]pyridines and 2-(aryloxymethyl) azacyclic analogs with therapeutic potetials for the treatment of central nervous system (CNS) disorders.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

D(-)Prolinol

68832-13-3

Di-tert-butyl dicarbonate

24424-99-5

(R)-1-Boc-pyrrolidin-2-yl-methanol

59378-81-3

Step 1: Dissolve (R)-2-(hydroxymethyl)pyrrolidine (2.0 g, 19.8 mmol) in dichloromethane (20 mL) and add 1 M aqueous sodium hydroxide solution (20 mL). A solution of di-tert-butyl dicarbonate (4.32 g, 19.8 mmol) in dichloromethane (10 mL) was added slowly and dropwise at room temperature. The reaction mixture was stirred at room temperature for 5 hours. After completion of the reaction, the organic and aqueous layers were separated. The organic layer was washed twice with distilled water and the aqueous layer was extracted with dichloromethane. All organic layers were combined and dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. Purification by recrystallization from hexane afforded the intermediate (R)-tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate in a yield of 2.60 g (65% yield).

References

[1] Patent: US5902819, 1999, A
[2] Patent: WO2006/19833, 2006, A1. Location in patent: Page/Page column 60
[3] European Journal of Organic Chemistry, 2002, # 14, p. 2391 - 2399
[4] Tetrahedron Letters, 1997, vol. 38, # 37, p. 6479 - 6482
[5] Tetrahedron Asymmetry, 1997, vol. 8, # 13, p. 2209 - 2213

Boc-D-prolinol Preparation Products And Raw materials

Raw materials

D(-)Prolinol N-Boc-D-proline Di-tert-butyl dicarbonate Dichloromethane Water
Sodium hydroxide

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Preparation Products

Boc-D-prolinol Suppliers

Global( 374)Suppliers
Supplier Tel Email Country ProdList Advantage
Tianjing Geneston Bio-tech Co.,Ltd. 022-60131465 18920720807 zishan_1986@163.com China 744 58
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Hobor Chemical Co., Ltd 13918007836 sales@hoborchem.com China 423 60
Shanghai Chiral Chemicals Inc. 021-37285021 13472570865 tym7xi@aliyun.com China 299 64
Shanghai Boyle Chemical Co., Ltd. 021-50182298 021-50180596 sales@boylechem.com China 2202 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
ITIC MEDCHEM(SUZHOU) CO.,LTD. 0512-68323967 18015559028 sales@iticmedchem.com China 528 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Supplier Advantage
Tianjing Geneston Bio-tech Co.,Ltd. 58
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Hobor Chemical Co., Ltd 60
Shanghai Chiral Chemicals Inc. 64
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
ITIC MEDCHEM(SUZHOU) CO.,LTD. 61
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81

View Lastest Price from Boc-D-prolinol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Boc-D-Pro-Ol pictures 2026-09-14 Boc-D-Pro-Ol
83435-58-9
 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
Boc-D-prolinol pictures 2026-09-11 Boc-D-prolinol
83435-58-9
 1KG 98%min 500kgs WUHAN FORTUNA CHEMICAL CO., LTD
Boc-D-prolinol pictures 2026-05-28 Boc-D-prolinol
83435-58-9
 $9.00 1KG 99.9 1 ton Hebei Chuanghai Biotechnology Co,.LTD
  • Boc-D-prolinol pictures
  • Boc-D-prolinol
    83435-58-9
  • $9.00
  • 99.9
  • Hebei Chuanghai Biotechnology Co,.LTD

Boc-D-prolinol Spectrum

Boc-D-prolinol(83435-58-9)1HNMR

83435-58-9(Boc-D-prolinol)Related Search:

Dexketoprofen trometamol N-Methyl-2-pyrrolidone Polyvinylpyrrolidone Hydrogenated Cottonseed Oil Pyrrolidine
phytosphingosine Ketorolac tromethamine Fosfomycin tromethamine D(-)Prolinol N-Vinyl-2-pyrrolidone
BOC-L-Prolinol Methyl-2-pyrrolidone 2-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester BOC-L-Serine Boc-D-prolinol
tert-Butoxide

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BOC-D-PRO-OL BOC-D-PROLINOL BOC-(R)-2-(HYDROXYMETHYL) PYRROLIDINE N-TERT-BUTOXYCARBONYL-D-PROLINOL N-T-BUTOXYCARBONYL-D-PROLINOL N-T-BOC-D-PROLINOL N-BOC-D-PROLINOL N-ALPHA-T-BOC-D-PROLINOL (R)-2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-(+)-1-BOC-2-PYRROLIDINEMETHANOL (R)-1-BOC-2-PYRROLIDINEMETHANOL (R)-(+)-1-(TERT-BUTOXYCARBONYL)-2-PYRROLIDINEMETHANOL (R)-(-)-N-BOC-PROLINOL (R)-N-TERT-BUTOXYCARBONYL PROLINOL (R)-1-Boc-2-(hydroxyMethyl)pyrrolidine tert-butyl (2R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate (R)-Boc-2-pyrrolidinemethanol Boc-D-Prolinol≥ 98% (HPLC) N-Boc-D-prolinol,99%e.e. N-BENZYL-D-PROLINOL 1-BOC-D-PROLINOL 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2R)- N-tert-Butoxycarbonyl-D-prolino N-alpha-t-Butyloxycarbonyl-D-prolinol, (R)-N-t-Butyloxycarbonyl-2-pyrrolidinemethanol BOC-D-PROLINOL LIQUID N-t-Boc-D-prolinol, N-Boc-D-prolinol, (R)-(+)-1-(tert-Butoxycarbonyl)-2-pyrrolidinemethanol N-tert-Butoxycarbonyl-D-prolinol,98% (R)-tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate N-Boc-D-prolinol,(R)-1-Boc-2-pyrrolidinemethanol (R)-(+)-1-Boc-2-pyrrolidinemethanol,(R)-(+)-1-(tert-Butoxycarbonyl)-2-pyrrolidinemethanol, N-t-Boc-D-prolinol, N-Boc-D-prolinol N-Boc-D-prolinol (R)-1-(tert-Butoxycarbonyl)-2-pyrrolidinemethanol (R)-1-Boc-2-pyrrolidinemethanol Boc-D-prolinol/(R)-(+)-1-(tert-Butoxycarbonyl)-2-pyrrolidineMethanol (3R)-2-(Hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester Boc-D-Proninol N-(tert-Butoxycarbonyl)-D-prolinol > idine-1-carboxyL )-pyrroL Boc-D-prolinol USP/EP/BP 1,1-Dimethylethyl (2R)-2-(hydroxymethyl)-1-pyrrolidinecarboxylate N-Boc-D-prolinol,97% (R)-(+)-1-Boc-2-pyrrolidinemethanol N-benzyl-D-prolino tert-butyl (R)-2-(hydroxymethyl)pyrrolidine-1-carboxylate 83435-58-9 Specialty Synthesis Peptide Synthesis Amino Alcohols Amino Acid Derivatives Chiral Building Blocks Glycidyl Compounds, etc. (Chiral) Synthetic Organic Chemistry Chiral Products Amino Acids Alcohol Aldehyde & acid series