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(R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

(R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester structure

CAS No.: 138108-72-2

Chemical Name:: (R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms: (R)-1-Boc-3-pyrrolidineMethanol;N-Boc-D-^b-prolinol;N-Boc-D-beta-prolinol;N-Boc-D-^b-prolinol, 97+%;(R)-1-Boc-3-(hydroxyMethy...;(R)-N-BOC-PYRROLIDINE-3-METHANOL;[R]-1-BOC-3-Pyrrolidinemethanol 97%;(R)-1-Boc-3-hydroxymethylpyrrolidine;1-Boc-3(R)-(HydroxyMethyl)Pyrrolidine;(3R)-1-Boc-3-(hydroxymethyl)pyrrolidine

CBNumber:: CB1668944

Molecular Formula:: C10H19NO3

Molecular Weight:: 201.26

MDL Number:: MFCD03094725

MOL File:: 138108-72-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:49:20

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(R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Properties

Boiling point	289.5±13.0 °C(Predicted)
Density	1.089
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Oil
pka	14.93±0.10(Predicted)
color	Clear Colourless to Pale Yellow
optical activity	Consistent with structure
Water Solubility	Slightly soluble in water
InChI	InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-5-4-8(6-11)7-12/h8,12H,4-7H2,1-3H3/t8-/m1/s1
InChIKey	HKIGXXRMJFUUKV-MRVPVSSYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CC[C@@H](CO)C1
CAS DataBase Reference	138108-72-2

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HS Code

2933998090

NFPA 704

	1
2		0

(R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester price More Price(75)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	280132	(R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Asreported	138108-72-2	500mg	$340	2026-06-03	Buy
Usbiological	280132	(R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Asreported	138108-72-2	1g	$496	2026-06-03	Buy
Usbiological	280132	(R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Asreported	138108-72-2	2g	$675	2026-06-03	Buy
Usbiological	280132	(R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Asreported	138108-72-2	5g	$917	2026-06-03	Buy
AstaTech	55693	(R)-1-BOC-3-HYDROXYMETHYLPYRROLIDINE 97%	138108-72-2	1G	$38	2026-04-30	Buy

Product number	Packaging	Price	Buy
280132	500mg	$340	Buy
280132	1g	$496	Buy
280132	2g	$675	Buy
280132	5g	$917	Buy
55693	1G	$38	Buy

(R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Synthesis

72925-16-7

(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

138108-72-2

Borane-THF complex (1.0 M, 17 mL, 16.9 mmol) was added slowly and dropwise to a stirred solution of (R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (1.21 g, 5.6 mmol) in tetrahydrofuran (THF, 30 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature over 30 minutes, followed by heating at 45 °C for 1 hour and then at 55 °C for 90 minutes. Upon completion of the reaction, the mixture was cooled to 0 °C and quenched by careful addition of 3N hydrochloric acid (30 mL). After stirring for 20 min at room temperature, the reaction mixture was extracted with ether (Et2O, 50 mL). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3, 20 mL) and brine (20 mL), dried over anhydrous sodium sulfate (Na2SO4), filtered, and concentrated under reduced pressure to afford (R)-tert-butyl-3-(hydroxymethyl)pyrrolidine-1-carboxylate (1.1 g, 91% yield) as a colorless oil.

References

[1] Patent: WO2011/150198, 2011, A1. Location in patent: Page/Page column 151
[2] Patent: WO2010/45212, 2010, A2. Location in patent: Page/Page column 299
[3] Patent: US2013/184313, 2013, A1. Location in patent: Paragraph 1541

(R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

(R)-1-N-Boc-beta-proline N-Boc-D-proline 1-Boc-3-hydroxymethylpyrrolidine Di-tert-butyl dicarbonate 3-Hydroxymethylpyrrolidine

Hydrochloric acid Borane THF Tetrahydrofuran

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Preparation Products

(R)-N-Boc-3-pyrrolidineacetic acid (R)-tert-butyl 3-(tosyloxyMethyl) pyrrolidine-1-carboxylate

(R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Suppliers

Global( 189)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ITIC MEDCHEM(SUZHOU) CO.,LTD.	0512-68323967 18015559028	sales@iticmedchem.com	China	528	61
Chengdu Firster Pharmaceutical Co., Ltd.	028-87078428 028-87074958	chengzhenyong@cdfirster.com	China	2580	60
Chengdu Firster Pharmaceutical Co., Ltd.	19138996873	670603485@qq.com	China	196	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
ChemFuture PharmaTech (Jiangsu) Ltd	5108538618	suger.wang@chemfuture.com	China	832	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62

Supplier	Advantage
ITIC MEDCHEM(SUZHOU) CO.,LTD.	61
Chengdu Firster Pharmaceutical Co., Ltd.	60
Chengdu Firster Pharmaceutical Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
ChemFuture PharmaTech (Jiangsu) Ltd	65
Alfa Aesar	84
Energy Chemical	61
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Pure Chemistry Scientific Inc.	62

View Lastest Price from (R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 138108-72-2		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 138108-72-2	$1.00	1KG	95%	500kg	Career Henan Chemical Co
2019-07-06	(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 138108-72-2	$1.00	1KG	95%	200KG	Career Henan Chemical Co

(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
138108-72-2
98%
Henan Aochuang Chemical Co.,Ltd.

(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
138108-72-2
$1.00
95%
Career Henan Chemical Co

(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
138108-72-2
$1.00
95%
Career Henan Chemical Co

(R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester Spectrum

(R)-3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(138108-72-2)¹HNMR

138108-72-2((R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester)Related Search:

1-Boc-3-methanesulfonyloxypyrrolidine (R)-N-Boc-3-aminomethylpiperidine 3-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-2-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BOC-L-Prolinol

(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid 2-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 2-(N,N-Dimethylaminomethyl)phenylboronic acid (R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (S)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Boc-(trans)-4-(2-bromo-phenyl)-pyrrolidine-3-carboxylic acid Boc-(trans)-4-(4-fluoro-phenyl)-pyrrolidine-3-carboxylic acid Boc-(trans)-4-(2-methyl-phenyl)-pyrrolidine-3-carboxylic acid trans-1-Boc-4-(4-chlorophenyl)-3-pyrrolidinecarboxylic acid Boc-L-transpro(4-CH2OH)

1-[(tert-Butyl)oxycarbonyl]-4-phenylpyrroline-3-carboxylic acid Boc-(trans)-4-(4-methyl-phenyl)-pyrrolidine-3-carboxylic acid trans-4-Amino-1-N-Boc-3-pyrrolidinecarboxylic acid ethyl ester

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3(R)-HYDROXYMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (R)-1-Boc-3-hydroxymethylpyrrolidine (R)-1-tert-Butoxycarbonylpyrrolidine-3-methanol (R)-N-BOC-PYRROLIDINE-3-METHANOL (3R)-3-(Hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester tert-butyl (3R)-3-(hydroxyMethyl)pyrrolidine-1-carboxylate N-Boc-D-^b-prolinol, 97+% 1-Boc-3(R)-(HydroxyMethyl)Pyrrolidine (R)-1-Boc-3-(hydroxyMethy... (R)-1-Boc-3-pyrrolidineMethanol (R)-3-hydroxyMethyl-pyrrolidine-1-carboxylic (3R)-N-tert-butyloxycarbonyl-3-hydroxymethylpyrrolidine 1-Pyrrolidinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)- N-Boc-D-^b-prolinol tert-butyl(R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate N-Boc-D-beta-prolinol (3R)-1-Boc-3-(hydroxymethyl)pyrrolidine [R]-1-BOC-3-Pyrrolidinemethanol 97% (R)-3-hydroxymethyl-pyrrolidine-1-carboxylic acid Tert-Butyl... 1,1-Dimethylethyl (3R)-3-(hydroxymethyl)-1-pyrrolidinecarboxylate (R)-3-Hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 138108-72-2 Heterocycle-other series pharmacetical