(S)-(-)-Methyl 2-chloropropionate
- CAS No.
- 73246-45-4
- Chemical Name:
- (S)-(-)-Methyl 2-chloropropionate
- Synonyms
- Methyl 2-chloropropanoate;Methyl (S)-2-Chloropropanoate;(S)-Methyl 2-chloropropanoate;methyl (2S)-2-chloropropanoate;METHYL (S)-(-)-2-CHLOROPROPIONATE;(S)-(-)-Methyl 2-chl;Methyl L-chloropropionate;Methyl 2-chloropropanoate, (S)-;(S)-(+)-METHYL 2-CHLOROPROPIONATE;(S)-2-Chloropropionic acid methyl
- CBNumber:
- CB2310312
- Molecular Formula:
- C4H7ClO2
- Molecular Weight:
- 122.55
- MDL Number:
- MFCD00062941
- MOL File:
- 73246-45-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 80-82 °C110 mm Hg(lit.) |
|---|---|
| Density | 1.143 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 101 °F |
| storage temp. | -20°C |
| form | clear liquid |
| color | Colorless to Almost colorless |
| optical activity | [α]20/D 26°, neat |
| BRN | 1720589 |
| InChI | InChI=1S/C4H7ClO2/c1-3(5)4(6)7-2/h3H,1-2H3/t3-/m0/s1 |
| InChIKey | JLEJCNOTNLZCHQ-VKHMYHEASA-N |
| SMILES | C(OC)(=O)[C@@H](Cl)C |
| CAS DataBase Reference | 73246-45-4(CAS DataBase Reference) |
| FDA UNII | I72Y13KL31 |
| NIST Chemistry Reference | Propanoic acid, 2-chloro-, methyl ester, (s)-(73246-45-4) |
| EPA Substance Registry System | Propanoic acid, 2-chloro-, methyl ester, (2S)- (73246-45-4) |
| UNSPSC Code | 12352101 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS08,GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H319-H373-H302 | |||||||||
| Precautionary statements | P210-P233-P240-P241+P242+P243-P264-P270-P280-P301+P312+P330-P303+P361+P353-P305+P351+P338+P337+P313-P403+P235-P501-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 10-36-48/22 | |||||||||
| Safety Statements | 23-26-36 | |||||||||
| RIDADR | UN 2933 3/PG 3 | |||||||||
| WGK Germany | 1 | |||||||||
| F | 19 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29159000 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 3 STOT RE 2 |
|||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
(S)-(-)-Methyl 2-chloropropionate price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C1634 | Methyl (S)-(-)-2-Chloropropionate >98.0%(GC) | 73246-45-4 | 5g | $126 | 2026-04-30 | Buy |
| Usbiological | 284807 | Methyl (S)-(-)-2-Chloropropionate Asreported | 73246-45-4 | 2g | $316 | 2026-06-03 | Buy |
| Usbiological | 284807 | Methyl (S)-(-)-2-Chloropropionate Asreported | 73246-45-4 | 5g | $455 | 2026-06-03 | Buy |
| Usbiological | 284807 | Methyl (S)-(-)-2-Chloropropionate Asreported | 73246-45-4 | 10g | $621 | 2026-06-03 | Buy |
| Usbiological | 284807 | Methyl (S)-(-)-2-Chloropropionate Asreported | 73246-45-4 | 25g | $921 | 2026-06-03 | Buy |
(S)-(-)-Methyl 2-chloropropionate Chemical Properties, Uses, Production
Uses
(-)-Methyl α-Chloropropionate is used in the preparation of TIPTP which is a therapeutic agent for rheumatoid arthritis.
Uses
Chiral starting material.
Synthesis
17392-83-5
73246-45-4
77287-29-7
Step I, preparation of Vilmerier reagent: 71.4 g (0.6 mol) of thionyl chloride was added to a 250 mL four-necked flask, cooled to 5~10°C in an ice-water bath, and 50.4 g (0.69 mol) of dry N,N-dimethylformamide was slowly added, the reaction was exothermic obviously, and mechanically stirred for 2 h to obtain a colorless Vilmerier reagent solution. Step II, Synthesis of methyl (S)-2-chloropropionate: a small amount of dioxane was added to the Vilmerier reagent solution obtained in Step I via a constant pressure dropping funnel at 20~30°C to form a mixed solution. Subsequently, 62.4 g (0.6 mol) of (R)-lactic acid methyl ester was slowly added dropwise to the mixed solution, and the reaction was markedly exothermic and gas was generated. After the dropwise addition, the reaction was continued with stirring and heated to 55°C for 6 h to obtain a solution of methyl (S)-2-chloropropionate. After the reaction was completed, the reaction mixture was cooled. Step III, post-treatment: the (S)-2-chloropropionic acid methyl ester solution obtained in Step II was washed, desolventized and distilled to obtain the product (S)-2-chloropropionic acid methyl ester 54.4 g, with 86% yield and 87% optical purity.
References
[1] Patent: CN103232344, 2016, B. Location in patent: Paragraph 0036-0039
(S)-(-)-Methyl 2-chloropropionate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NanJing JingWei Chemical Co., Ltd. | 13270709979 | njjwchem@163.com | China | 81 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6742 | 52 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
View Latest Price from (S)-(-)-Methyl 2-chloropropionate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | (S)-(-)-Methyl 2-chloropropionate
73246-45-4
|
$100.00 | 1KG | 99% | Career Henan Chemical Co |
-
- (S)-(-)-Methyl 2-chloropropionate
73246-45-4
- $100.00
- 99%
- Career Henan Chemical Co
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