3-(Chloromethyl)benzoic acid
- CAS No.
- 31719-77-4
- Chemical Name:
- 3-(Chloromethyl)benzoic acid
- Synonyms
- NSC 49611;α-chloro-m-toluic acid;3-(Chloromethyl)Benzoic;Bedaquiline Impurity 106;m-Chloromethylbenzoic acid;ALPHA-CHLORO-M-TOLUIC ACID;3-(CHLOROMETHYL)BENZOIC ACID;Benzoic acid, 3-(chloromethyl)-;3-(CHLOROMETHYL) BENZOIC ACID 98%;metachloromethylbenzenemacetic acid
- CBNumber:
- CB2335106
- Molecular Formula:
- C8H7ClO2
- Molecular Weight:
- 170.59
- MDL Number:
- MFCD00191922
- MOL File:
- 31719-77-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 3-(Chloromethyl)benzoic acid 97% | 424315 | 5g | $24.7 |
| 3-(Chloromethyl)benzoic acid 97% | 424315 | 25g | $108 |
| 3-(Chloromethyl)benzoic Acid 97% | AS40268 | 5g | $27 |
| 3-(Chloromethyl)benzoic Acid 97% | AS40268 | 25g | $57 |
| 3-(Chloromethyl)benzoic acid 98%(GC) | L370 | 5g | $16 |
| More product size | |||
| Melting point | 136-138 °C (lit.) |
|---|---|
| Boiling point | 327.2±25.0 °C(Predicted) |
| Density | 1.315±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | methanol: 20 mg/mL, clear |
| pka | 4.09±0.10(Predicted) |
| form | solid |
| color | White |
| BRN | 637114 |
| InChI | 1S/C8H7ClO2/c9-5-6-2-1-3-7(4-6)8(10)11/h1-4H,5H2,(H,10,11) |
| InChIKey | PBSUMBYSVFTMNG-UHFFFAOYSA-N |
| SMILES | OC(=O)c1cccc(CCl)c1 |
| CAS DataBase Reference | 31719-77-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312+H332-H314 | |||||||||
| Precautionary statements | P260-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 36/37/38-34-20/21/22 | |||||||||
| Safety Statements | 26-36-45-36/37/39 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 19 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | Ⅱ | |||||||||
| HS Code | 2916399090 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Skin Corr. 1B |
|||||||||
| NFPA 704 |
|
3-(Chloromethyl)benzoic acid price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 424315 | 3-(Chloromethyl)benzoic acid 97% | 31719-77-4 | 5g | $24.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | 424315 | 3-(Chloromethyl)benzoic acid 97% | 31719-77-4 | 25g | $108 | 2026-04-30 | Buy |
| Activate Scientific | AS40268 | 3-(Chloromethyl)benzoic Acid 97% | 31719-77-4 | 5g | $27 | 2026-06-04 | Buy |
| Activate Scientific | AS40268 | 3-(Chloromethyl)benzoic Acid 97% | 31719-77-4 | 25g | $57 | 2026-06-04 | Buy |
| AK Scientific | L370 | 3-(Chloromethyl)benzoic acid 98%(GC) | 31719-77-4 | 5g | $16 | 2026-06-04 | Buy |
3-(Chloromethyl)benzoic acid Chemical Properties,Uses,Production
Uses
3-(Chloromethyl)benzoic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.
General Description
3-(Chloromethyl)benzoic acid (m-Chloromethylbenzoic acid) is a meta-substituted benzoic acid derivative. Correlations between Hammett substituent constants and calculated dipole moments and molecular transform and normalized molecular moment structure indices for m-chloromethylbenzoic acid was investigated. Hammett constants were observed to be linearly related only to the normalized charge moment index.
Synthesis
50-00-0
98-88-4
31719-77-4
The general procedure for the synthesis of 3-(chloromethyl)benzoic acid from formaldehyde and benzoyl chloride was as follows: 50 mL of chloroform and 20 mL of carbon tetrachloride were added to an autoclave. Subsequently, 0.1 mol of benzoyl chloride, 0.13 mol of paraformaldehyde and 0.02 mol of anhydrous manganese dichloride were added to it and nitrogen was charged to a pressure of 0.5 MPa. The reaction mixture was allowed to react at a constant temperature of 40-50 °C for 12 h. After the reaction was completed, the mixture was cooled down to a temperature of 0.5 °C. The reaction was carried out at a temperature of 0.5 °C. Upon completion of the reaction, the mixture was cooled to room temperature and the nitrogen was slowly released. The reaction solution was poured into 100 mL of ice water, stirred for 0.5 h, and left to stratify. The organic layer was concentrated under reduced pressure to give the crude product. A portion of the crude product was taken and analyzed by HPLC, which showed that the crude product contained 0.5% benzoic acid and 95.6% 3-(chloromethyl)benzoic acid.
References
[1] Patent: CN105384620, 2016, A. Location in patent: Paragraph 0038; 0039
3-(Chloromethyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8737 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3955 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-17732866630 | mina@chuanghaibio.com | China | 18114 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2984 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6361 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 | marketing1@neostarunited.com | China | 8827 | 58 |
View Lastest Price from 3-(Chloromethyl)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 3-(Chloromethyl)benzoic acid
31719-77-4
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-06-27 | 3-(Chloromethyl)benzoic acid
31719-77-4
|
$10.00 | 1kg | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2024-07-21 | 3-(Chloromethyl)benzoic acid
31719-77-4
|
$1.00 | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 3-(Chloromethyl)benzoic acid
31719-77-4
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-(Chloromethyl)benzoic acid
31719-77-4
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-(Chloromethyl)benzoic acid
31719-77-4
- $1.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
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