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3,5-Difluoroaniline

3,5-Difluoroaniline Structure
3,5-Difluoroaniline structure
CAS No.
372-39-4
Chemical Name:
3,5-Difluoroaniline
Synonyms
3,5-DIFLUOROBENZENAMINE;NSC 81289;5-Difluoroaniline;3,5-Difluoranilin;3,5-DIFLUOROANILINE;3, 5-2 fluoro aniline;3,5-Difluoroaniline>3,5-Difluoroaniline,98%;3,5-Difluorophenylamine;3,5-Difluoroaniline 98%
CBNumber:
CB2339018
Molecular Formula:
C6H5F2N
Molecular Weight:
129.11
MDL Number:
MFCD00007763
MOL File:
372-39-4.mol
MSDS File:
SDS
Last updated:2026-03-10 10:40:33
Product description Number Pack Size Price
3,5-Difluoroaniline >98.0%(GC) D2665 5g $36
3,5-Difluoroaniline >98.0%(GC) D2665 25g $176
3,5-Difluoroaniline D442325 5g $75
3,5-Difluoroaniline FD64333 500g $75
3,5-Difluoroaniline 98% JK410839 5g $76
More product size
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3,5-Difluoroaniline Properties

Melting point 37-41 °C (lit.)
Boiling point 80°C 20mm
Density 1,295 g/cm3
refractive index 1,512-1,514
Flash point 167 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
Water Solubility Insoluble in water
form Low Melting Solid
pka 2.57±0.10(Predicted)
color White to yellow
BRN 2802286
InChI InChI=1S/C6H5F2N/c7-4-1-5(8)3-6(9)2-4/h1-3H,9H2
InChIKey KQOIBXZRCYFZSO-UHFFFAOYSA-N
SMILES C1(N)=CC(F)=CC(F)=C1
CAS DataBase Reference 372-39-4(CAS DataBase Reference)
FDA UNII 93F28C8C0X
EPA Substance Registry System 3,5-Difluoroaniline (372-39-4)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS07
Signal word  Warning
Hazard statements  H302-H312-H332-H335-H302+H312+H332-H301+H311+H331-H315-H319
Precautionary statements  P304+P340-P305+P351+P338-P501a-P261-P264-P270-P271-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P305+P351+P338+P337+P313-P403+P233-P405-P501-P280
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  28-36/37/39-26-36
RIDADR  UN 1325 4.1/PG 2
WGK Germany  3
F  8-10-23
Hazard Note  Irritant
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  III
HS Code  29214200
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

3,5-Difluoroaniline price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D2665 3,5-Difluoroaniline >98.0%(GC) 372-39-4 5g $36 2026-03-19 Buy
TCI Chemical D2665 3,5-Difluoroaniline >98.0%(GC) 372-39-4 25g $176 2026-03-19 Buy
TRC D442325 3,5-Difluoroaniline 372-39-4 5g $75 2021-12-16 Buy
Biosynth Carbosynth FD64333 3,5-Difluoroaniline 372-39-4 500g $75 2021-12-16 Buy
Frontier Specialty Chemicals JK410839 3,5-Difluoroaniline 98% 372-39-4 5g $76 2021-12-16 Buy
Product number Packaging Price Buy
D2665 5g $36 Buy
D2665 25g $176 Buy
D442325 5g $75 Buy
FD64333 500g $75 Buy
JK410839 5g $76 Buy

3,5-Difluoroaniline Chemical Properties,Uses,Production

Synthesis

Work on halogenated benzenes has also demonstrated the versatility of this technique and a variety of fluoro-chloro and -bromo benzenes may be de-brominated and de-chlorinated. Two patents describe removal of chlorine from 2,6-dichloro-3,5- difluoronitrobenzene giving 3,5-difluoroaniline. Synthesis of 3,5-Difluoroaniline

Chemical Properties

white to yellowish low melting solid

Uses

3,5-Difluoroaniline has been used in the preparation of 3,5-difluorodimethylaniline.

Application

3,5-Difluoroaniline is mainly used as a key intermediate in the synthesis of complex organic molecules such as pharmaceuticals (e.g., antibacterial drugs, anti-inflammatory drugs), pesticides (e.g., herbicides), and dyes.

General Description

In vitro nephrotoxic effects of 3,5-difluoroaniline has been investigated in renal cortical slices obtained from the kidneys of untreated, male Fischer 344 rats.

References

[1] Patent: CN108314624, 2018, A. Location in patent: Paragraph 0054; 0055; 0056; 0057

3,5-Difluoroaniline synthesis

461-96-1
372-39-4
Synthesis of 3,5-Difluoroaniline from 1-Bromo-3,5-difluorobenzene

3,5-Difluoroaniline Preparation Products And Raw materials

Raw materials

1-Bromo-3,5-difluorobenzene N-benzyl-3,5-difluoroaniline Hydrogen Methanol Activated carbon
Palladium Sulfuric acid

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Preparation Products

2-AMINO-4,6-DIFLUOROBENZOIC ACID 2,4-dibromo-1,3,5-trifluorobenzene 4-AMINO-2,6-DIFLUORO-BENZALDEHYDE 2,4,6-Trifluorochlorobenzene 3,5-Difluoro-4-iodoaniline
3,5-DIFLUOROBENZENESULFONAMIDE N-Methyl 3,5-difluoroaniline 1,3,5-Trifluorobenzene N-(3,5-Difluorophenyl)-4-nitrobenzenesulfonaMide, 97% Benzenamine, 3,5-difluoro-N,N-dimethyl- (9CI)
N-(3,5-Difluorophenyl)-4-fluorobenzaMide, 97% 2-(3,5-Difluorophenoxy)acetic acid 5,7-Difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester

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3,5-Difluoroaniline Suppliers

Global( 470)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Qinmu Fine Chemical Co.,Ltd.
+8618660799346 sales@qinmuchem.com China 1008 58
Shandong Believe Chemical PTE.LTD
+86-18553607090 +8618553607090 1093908296@qq.com China 1663 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13815 58
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21592 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29822 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Supplier Advantage
Jinan Qinmu Fine Chemical Co.,Ltd.
58
Shandong Believe Chemical PTE.LTD
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Hi-Tech Chemistry Corp 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58

View Lastest Price from 3,5-Difluoroaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,5-Difluoroaniline pictures 2025-12-01 3,5-Difluoroaniline
372-39-4
 US $0.00 / kg 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
3,5-Difluoroaniline pictures 2025-09-25 3,5-Difluoroaniline
372-39-4
 US $8.00-0.80 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
3,5-Difluoroaniline pictures 2025-06-27 3,5-Difluoroaniline
372-39-4
 US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd

3,5-Difluoroaniline Spectrum

3,5-Difluoroaniline(372-39-4)MS3,5-Difluoroaniline(372-39-4)1HNMR3,5-Difluoroaniline(372-39-4)13CNMR3,5-Difluoroaniline(372-39-4)IR13,5-Difluoroaniline(372-39-4)IR23,5-Difluoroaniline(372-39-4)Raman

372-39-4(3,5-Difluoroaniline)Related Search:

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3-Fluoroaniline Sodium diphenylamine-4-sulfonate 2-Aminobenzotrifluoride N,N-Dimethyl-1,4-phenylenediamine 2,4-Difluoroaniline97%
2,3,4,5-Tetrafluoronitrobenzene 3,5-Difluoronitrobenzene 4-AMINO-2,3,5,6-TETRAFLUOROBENZOIC ACID 4-AMINO-2,3,5,6-TETRAFLUOROBENZAMIDE 2,6-Difluoroaniline
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3,5-Difluoroaniline 98% 3,5-DIFLUOROBENZENEAMINE 3,5-DIFLUOROBENZENAMINE 3,5-DIFLUOROANILINE 3,5-Difluoroaniline(AntibacterialAntiphlogistic,WeedKiller)(C6H5F2N) 3,5-Difluoroaniline,98% Benzenamine, 3,5-difluoro 3,5-Difluoronitroaniline 3,5-Difluorophenylamine 5-Difluoroaniline 3,5-Difluoroaniline, 98% 1GR Aniline, 3,5-difluoro- (6CI,7CI,8CI) NSC 81289 3,5-Difluoroaniline, 97+% 3, 5-2 fluoro aniline 3,5-Difluoranilin 3,5-Difluoroaniline> 1,2,3,5 - four fluorine benzene 3,5-Difluoroaniline ISO 9001：2015 REACH TIANFUCHEM--High purity 372-39-4 3,5-Difluoroaniline 372-39-4 72-39-4 3863-11-5 C2 to C6 Amines Building Blocks Organic Building Blocks Nitrogen Compounds Fluorobenzene Anilines, Aromatic Amines and Nitro Compounds Miscellaneous Amines C2 to C6 Nitrogen Compounds Fluorobenzene Series bc0001