2-Cyanopyridine-5-boronic acid pinacol ester
- CAS No.
- 741709-63-7
- Chemical Name:
- 2-Cyanopyridine-5-boronic acid pinacol ester
- Synonyms
- 16 2-cyano pyridine -5-boronic acid;2-CYANOPYRIDINE-5-BORONIC ACID PICOL ESTER;2-Cyanopyridine-5-boronic acid pinacol este;6-Cyano-3-pyridylboronic Acid Pinacol Ester;6-Cyanopyridine-3-boronic acid pinacol ester;2-Cyanopyridine-5-boronic acid pinacol ester;(2-Cyanopyridin-5-yl)boronic acid pinacol ester;(6-CYANOPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;2-(6-Cyano-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile
- CBNumber:
- CB2376918
- Molecular Formula:
- C12H15BN2O2
- Molecular Weight:
- 230.07
- MDL Number:
- MFCD06657825
- MOL File:
- 741709-63-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 105-106℃ |
|---|---|
| Boiling point | 370.7±27.0 °C(Predicted) |
| Density | 1.10 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | -0.33±0.12(Predicted) |
| form | powder to crystal |
| color | White to Light yellow to Light orange |
| Water Solubility | Slightly soluble in water. |
| CAS DataBase Reference | 741709-63-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37/38-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
2-Cyanopyridine-5-boronic acid pinacol ester price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3126 | 2-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(T) | 741709-63-7 | 200mg | $38 | 2026-04-30 | Buy |
| TCI Chemical | C3126 | 2-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(T) | 741709-63-7 | 1g | $131 | 2026-04-30 | Buy |
| Usbiological | 269117 | 2-Cyanopyridine-5-boronic acid pinacol ester Asreported | 741709-63-7 | 500mg | $333 | 2026-06-03 | Buy |
| Usbiological | 269117 | 2-Cyanopyridine-5-boronic acid pinacol ester Asreported | 741709-63-7 | 1g | $475 | 2026-06-03 | Buy |
| Usbiological | 269117 | 2-Cyanopyridine-5-boronic acid pinacol ester Asreported | 741709-63-7 | 2g | $644 | 2026-06-03 | Buy |
2-Cyanopyridine-5-boronic acid pinacol ester Chemical Properties, Uses, Production
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is used in suzuki reactions.
Synthesis
97483-77-7
73183-34-3
741709-63-7
To a 250 mL round bottom flask was added 5-bromo-2-cyanopyridine (3.0 g, 16.39 mmol), bis(pinacolato)diboron (4.58 g, 18.03 mmol), potassium acetate (5.47 g, 55.74 mmol), and dimethyl sulfoxide (100 mL). After degassing for 20 min, [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride dichloromethane complex (1.39 g, 1.64 mmol) was added. The reaction mixture was stirred at 80 °C for 24 h, followed by continued stirring at room temperature for 3 days. Upon completion of the reaction, 50 mL of water was added and the product was extracted with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The dark residue was purified by fast column chromatography (eluent: 20% acetone/hexane) to give a red solid. The solid was ground with hexane to give 1.72 g (46% yield) of the target product 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyanopyridine as a light pink solid.
References
[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 13, p. 5473 - 5494
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 5, p. 1277 - 1281
[3] Patent: US2009/136473, 2009, A1. Location in patent: Page/Page column 36; 61
[4] Patent: US2014/364414, 2014, A1. Location in patent: Paragraph 0438; 0449-0450
[5] Patent: WO2009/74812, 2009, A1. Location in patent: Page/Page column 70
2-Cyanopyridine-5-boronic acid pinacol ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 2-Cyanopyridine-5-boronic acid pinacol ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 2-Cyanopyridine-5-boronic acid pinacol ester
741709-63-7
|
$1.60-9.60 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2019-07-14 | 2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER
741709-63-7
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 2-Cyanopyridine-5-boronic acid pinacol ester
741709-63-7
- $1.60-9.60
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2-CYANOPYRIDINE-5-BORONIC ACID PINACOL ESTER
741709-63-7
- $8.80
- 97%-99%
- Career Henan Chemical Co
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