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BETONICINE

CAS No.
515-25-3
Chemical Name:
BETONICINE
Synonyms
Nsc655264;Aids013405;BETONICINE;Achilleine;Aids-013405;4-Hydroxy-stachydrine;L-4-HYDROXYPROLINE BETAINE;rans-4-hydroxy-L-prolinebetaine;trans-4-hydroxy-L-proline betaine;13C,2H3]-Trans-4-Hydroxy-L-proline betaine
CBNumber:
CB2384513
Molecular Formula:
C7H13NO3
Molecular Weight:
159.18
MDL Number:
MFCD00063554
MOL File:
515-25-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:31
Product description Number Pack Size Price
Betonicine ≥98% 379686 10mg $638
Betonicine FB34887 2mg $181.42
Betonicine FB34887 5mg $290.3
Betonicine FB34887 10mg $435.3
Betonicine FB34887 25mg $998
More product size

BETONICINE Properties

Melting point 246-248°C
alpha D20 -34.2° (c = 1.0)
Boiling point 284.67°C (rough estimate)
Density 1.2013 (rough estimate)
refractive index 1.4760 (estimate)
LogP -4.240 (est)
FDA UNII FBA654632Q

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

BETONICINE price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 379686 Betonicine ≥98% 515-25-3 10mg $638 2026-06-03 Buy
Biosynth FB34887 Betonicine 515-25-3 2mg $181.42 2026-06-04 Buy
Biosynth FB34887 Betonicine 515-25-3 5mg $290.3 2026-06-04 Buy
Biosynth FB34887 Betonicine 515-25-3 10mg $435.3 2026-06-04 Buy
Biosynth FB34887 Betonicine 515-25-3 25mg $998 2026-06-04 Buy
Product number Packaging Price Buy
379686 10mg $638 Buy
FB34887 2mg $181.42 Buy
FB34887 5mg $290.3 Buy
FB34887 10mg $435.3 Buy
FB34887 25mg $998 Buy

BETONICINE Chemical Properties,Uses,Production

Uses

Betonicine (Achilleine), an alkaloid, has cell protectant activity. Betonicine protects Bacillus subtilis against extremes in osmolarity and growth temperatures[1].

Definition

ChEBI: An amino-acid betaine that is trans-4-hydroxy-L-proline zwitterion in which both of the hydrogens attached to the nitrogen have been replaced by methyl groups.

References

[1] Bashir A, et al. Plant-derived compatible solutes proline betaine and betonicine confer enhanced osmotic and temperature stress tolerance to Bacillus subtilis. Microbiology (Reading). 2014 Oct;160(Pt 10):2283-2294. DOI:10.1099/mic.0.079665-0

51-35-4
515-25-3
Synthesis of BETONICINE from L-Hydroxyproline

BETONICINE Preparation Products And Raw materials

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trans-2-Carboxy-4-hydroxy-1,1-dimethylpyrrolidinium hydroxide, inner salt (2S,4R)-4-Hydroxy-2-carboxylato-1,1-dimethylpyrrolidin-1-ium 4-Hydroxy-1,1-dimethylpyrrolidinium-2-carboxylate 4-Hydroxy-stachydrine Aids013405 Aids-013405 Nsc655264 Pyrrolidinium, 2-carboxy-4-hydroxy-1,1-dimethyl-, inner salt, (2S,4S)- L-4-HYDROXYPROLINE BETAINE BETONICINE (2S-trans)-2-carboxylato-4-hydroxy-1,1-dimethylpyrrolidinium trans-4-hydroxy-L-proline betaine rans-4-hydroxy-L-prolinebetaine Pyrrolidinium, 2-?carboxy-?4-?hydroxy-?1,?1-?dimethyl-?, inner salt, (2S,?4R)?- Achilleine 13C,2H3]-Trans-4-Hydroxy-L-proline betaine 515-25-3 Alkaloids