(S)-BAY-293
- CAS No.
- 2244904-69-4
- Chemical Name:
- (S)-BAY-293
- Synonyms
- BAY 294;(S)-BAY-293;BAY 293 Negative Control;4-Quinazolinamine, 6,7-dimethoxy-2-methyl-N-[(1S)-1-[4-[2-[(methylamino)methyl]phenyl]-2-thienyl]ethyl]-
- CBNumber:
- CB25867497
- Molecular Formula:
- C25H28N4O2S
- Molecular Weight:
- 448.58
- MDL Number:
- MOL File:
- 2244904-69-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 553.4±50.0 °C(Predicted) |
|---|---|
| Density | 1.218±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 9.61±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| optical activity | [α]/D +86.0 to +106.0°, c =1.0 in DMSO |
| InChIKey | WEGLOYDTDILXDA-HNNXBMFYSA-N |
| SMILES | C[C@@H](C1=CC(C2=CC=CC=C2CNC)=CS1)NC3=C4C=C(C(OC)=CC4=NC(C)=N3)OC |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
(S)-BAY-293 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | UPD90469 | BAY-294 | 2244904-69-4 | 25mg | $1091.5 | 2026-06-05 | Buy |
| Biosynth | UPD90469 | BAY-294 | 2244904-69-4 | 50mg | $1518.5 | 2026-06-05 | Buy |
| ChemScene | CS-0087613 | (S)-BAY-293 97.8% | 2244904-69-4 | 5mg | $390 | 2026-06-04 | Buy |
| Tocris | 6906 | BAY293NegativeControl ≥98%(HPLC) | 2244904-69-4 | 5 | $235 | 2021-12-16 | Buy |
(S)-BAY-293 Chemical Properties, Uses, Production
Uses
(S)-BAY-293 is a negative control of BAY 293. BAY 293 is a potent KRAS-SOS1 interaction inhibitor[1].
Biological Activity
BAY-294 corresponds to the (S)-enantiomer of and the recommended control for the selective SOS1-KRAS interaction inhibitor BAY-293 (IC50 = 2.34 μM/BAY-294 vs. 21 nM/BAY-293; 10 nM hSOS1c at & 5 nM hKRAS G12C). BAY-294 exhibits little potency against SOS1-mediated KRAS activation (IC50 = 3.91 μM/BAY-294 vs. 52 nM/BAY-293; 10 nM SOS1c at & 50 nM wt hKRAS).
storage
Store at -20°C
References
[1] Hillig RC, et, al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2551-2560. DOI:10.1073/pnas.1812963116
(S)-BAY-293 Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-BAY-293 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| SINO High Goal Chemical Technology Co., Ltd. | 021-57646680 18306277365 | guoxin@chembiobanksh.com | China | 2819 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Suzhou Haiben Pharmaceutical Co., Ltd | 19353112242 | 1816280386@qq.com | China | 8041 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 9998 | 58 |
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